The Antiviral Activities of Poly-ADP-Ribose Polymerases [PDF]
Viruses, 2021 The poly-adenosine diphosphate (ADP)-ribose polymerases (PARPs) are responsible for ADP-ribosylation, a reversible post-translational modification involved in many cellular processes including DNA damage repair, chromatin remodeling, regulation of ...
Mathilde Malgras +4 more
doaj +6 more sources
Mitotic functions of poly(ADP-ribose) polymerases [PDF]
Biochemical Pharmacology, 2019 Mitosis ensures accurate segregation of duplicated DNA through tight regulation of chromosome condensation, bipolar spindle assembly, chromosome alignment in the metaphase plate, chromosome segregation and cytokinesis. Poly(ADP-ribose) polymerases (PARPs), in particular PARP1, PARP2, PARP3, PARP5a (TNKS1), as well as poly(ADP-ribose) glycohydrolase ...
Dea Slade
exaly +5 more sources
Adipose tissue NAD+-homeostasis, sirtuins and poly(ADP-ribose) polymerases -important players in mitochondrial metabolism and metabolic health [PDF]
Redox Biology, 2017 Obesity, a chronic state of energy overload, is characterized by adipose tissue dysfunction that is considered to be the major driver for obesity associated metabolic complications.
Riikka Jokinen +3 more
doaj +4 more sources
Poly(ADP-ribose)polymerases inhibitors prevent early mitochondrial fragmentation and hepatocyte cell death induced by H2O2. [PDF]
PLoS ONE, 2017 Poly(ADP-ribose)polymerases (PARPs) are a family of NAD+ consuming enzymes that play a crucial role in many cellular processes, most clearly in maintaining genome integrity.
Sandra M Martín-Guerrero +7 more
doaj +3 more sources
RNA Regulation by Poly(ADP-Ribose) Polymerases. [PDF]
Mol Cell, 2015 Posttranscriptional regulation of RNA facilitates the fine-tuning of gene expression. It occurs through multiple pathways that include the nuclear processing of mRNA and its precursors, mRNA silencing, regulation of mRNA decay, and regulation of translation. Poly(ADP-ribose) polymerases (PARPs), enzymes that modify target proteins with ADP-ribose, play
Bock FJ, Todorova TT, Chang P.
europepmc +4 more sources
Poly (ADP-ribose) polymerases as PET imaging targets for central nervous system diseases [PDF]
Frontiers in Medicine, 2022 Poly (ADP-ribose) polymerases (PARPs) constitute of 17 members that are associated with divergent cellular processes and play a crucial role in DNA repair, chromatin organization, genome integrity, apoptosis, and inflammation.
Jie Tong +4 more
doaj +2 more sources
Analysis of poly(ADP-Ribose) polymerases in Arabidopsis telomere biology. [PDF]
PLoS ONE, 2014 Maintaining the length of the telomere tract at chromosome ends is a complex process vital to normal cell division. Telomere length is controlled through the action of telomerase as well as a cadre of telomere-associated proteins that facilitate ...
Kara A Boltz +3 more
doaj +2 more sources
Synergistic Cellular Toxicity from Inhibition of Poly(ADP-ribose) Glycohydrolase (PARG) and Ubiquitin-Specific Protease 1 (USP1) [PDF]
ToxicsUbiquitin-specific protease 1 (USP1) is an emerging target for poly(ADP-ribose) polymerase 1 (PARP1) inhibitor-resistant and BRCA1/BRCA2 mutant tumors.
Stefan M. Leonard +3 more
doaj +2 more sources
Role of poly(ADP-ribose) polymerases in male reproduction. [PDF]
Spermatogenesis, 2013 Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes involved in a wide variety of biological processes, including DNA repair and maintenance of genomic stability following genotoxic stress, and regulates the expression of various proteins at the transcriptional level as well as replication and differentiation.
Celik-Ozenci C, Tasatargil A.
europepmc +4 more sources
Excessive poly(ADP)-ribosylation in the inflamed mucosa of pediatric celiac disease points to a novel inflammatory mechanism and therapeutic target [PDF]
Molecular and Cellular PediatricsBackground Celiac disease (CD) is an immune-mediated enteropathy triggered by gluten exposure in genetically susceptible individuals, characterized by chronic intestinal inflammation, epithelial damage, and immune dysregulation.
Tala M. Haddadin +6 more
doaj +2 more sources