Results 31 to 40 of about 9,722 (255)
Research Advances in the Role of the Poly ADP Ribose Polymerase Family in Cancer
Frontiers in Oncology, 2021 Poly ADP ribose polymerases (PARPs) catalyze the modification of acceptor proteins, DNA, or RNA with ADP-ribose, which plays an important role in maintaining genomic stability and regulating signaling pathways. The rapid development of PARP1/2 inhibitors
Huanhuan Sha +4 more
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Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression [PDF]
, 2011 Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known
Renate Renkawitz-Pohl +14 more
core +1 more source
Журнал органічної та фармацевтичної хімії, 2023 Poly(ADP-ribose) polymerases (PARPs) are key enzymes in the DNA repair pathway. Inhibitors of these enzymes belong to a new type of anticancer drugs that selectively kill cancer cells by targeting the homologous recombination genetic defects.
Oleh O. Lukianov +4 more
doaj +1 more source
Poly(ADP-ribose) polymerases covalently modify strand break termini in DNA fragments in vitro. [PDF]
Nucleic Acids Res, 2016 Fondation ARC (http://www.arc-cancer.net) [PJA20151203415 to A.A.I.]; ERA.Net RUS Plus (www.eranet-rus.eu) [#306 to A.A.I. and RFBR-16-54-76010 to O.I.L.]; Electricité de France (http://www.edf.fr) [RB 2016-17 to M.K.S.]; Science Committee of the ...
Talhaoui I +10 more
europepmc +2 more sources
Novel modulators of poly(ADP-ribose) polymerase [PDF]
Trends in Pharmacological Sciences, 2006 The nuclear enzyme poly(ADP-ribose) polymerase (PARP)-1 has an important role in regulating cell death and cellular responses to DNA repair. Pharmacological inhibitors of PARP have entered clinical testing as cytoprotective agents in cardiovascular diseases and as adjunct antitumor therapeutics.
Csaba, Szabo +2 more
openaire +2 more sources
A Review on DNA Repair Inhibition by PARP Inhibitors in Cancer Therapy
Folia Medica, 2018 The DNA repair process protects the cells from DNA damaging agent by multiple pathways. Majority of the cancer therapy cause DNA damage which leads to apoptosis.
Shah Ashish P. +3 more
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ADP-ribosylation: from molecular mechanisms to human disease [PDF]
Genetics and Molecular BiologyPost-translational modification of proteins by ADP-ribosylation, catalysed by poly (ADP-ribose) polymerases (PARPs) using NAD+ as a substrate, plays central roles in DNA damage signalling and repair, modulates a range of cellular signalling cascades and ...
Nicolas C. Hoch, Luis M. Polo
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Poly(ADP‐Ribose) Polymerase in Plant Nuclei [PDF]
European Journal of Biochemistry, 1994 We show that poly(ADP‐ribose) polymerase is present in maize, pea and wheat nuclei. We have identified the enzyme product as poly(ADP‐ribose) by purification and electrophoresis on a DNA sequencing gel. This reveals a polymer ladder consisting of up to 45 residues. The polymer product from maize, after digestion with snake venom phosphodiesterase, gave
Y M, Chen, S, Shall, M, O'Farrell
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Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. [PDF]
PLoS ONE, 2012 Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
Julie A Tucker +9 more
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PARP12 is required for mitochondrial function maintenance in thermogenic adipocytes
Adipocyte, 2022 PARP12 is a member of poly-ADP-ribosyl polymerase (PARPs), which has been characterized for its antiviral function. Yet its physiological implication in adipocytes remains unknown.
Fan Hu +9 more
doaj +1 more source