Results 51 to 60 of about 15,256 (194)

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy

Frontiers in Molecular Biosciences, 2020
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins.
Daniel Harrision, Polly Gravells, Ruth Thompson, Helen E. Bryant   +3 more
doaj   +1 more source

Poly(ADP-ribose) polymerases regulate cell division and development in Arabidopsis roots [PDF]

, 2017
Root organogenesis involves cell division, differentiation and expansion. The molecular mechanisms regulating root development are not fully understood. In this study, we identified poly (ADP-ribose) polymerases (PARPs) as new players in root development.
Ge, Xiaochun, Gu, Zongyin, Liu, Caifeng, Liu, Weiwei, Ma, Hong, Wang, Wenjing, Wu, Qiao, Xu, Ping   +7 more
core   +1 more source

The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation

Viruses, 2020
Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection.
Yousef M. O. Alhammad, Anthony R. Fehr
doaj   +1 more source

Assessment of Poly(ADP-ribose) Polymerase1 (PARP1) expression and activity in cells purified from blood and milk of dairy cattle [PDF]

, 2018
Poly(ADP-ribosyl)ation (PAR) is a post-translational protein modification catalysed by enzyme member of the poly(ADP-ribose) polymerases (PARPs) family. The activation of several PARPs is triggered by DNA strand breakage and the main PARP enzyme involved
Buttazzoni, Luca, De Matteis, Giovanna, Grandoni, Francesco, Meyer, Ralph G., Meyer-Ficca, Mirella L., Moioli, Bianca, Reale, Anna, Scatà, Maria Carmela   +7 more
core   +1 more source

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells [version 2; referees: 2 approved]

F1000Research, 2016
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A. Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D. Waddell, Donald J. Ogilvie   +10 more
doaj   +1 more source

Crocetin antagonizes parthanatos in ischemic stroke via inhibiting NOX2 and preserving mitochondrial hexokinase-I

Cell Death and Disease, 2023
Parthanatos is one of the major pathways of programmed cell death in ischemic stroke characterized by DNA damage, poly (ADP-ribose) polymerases (PARP) activation, and poly (ADP-ribose) (PAR) formation.
Hao Wu, Ying Li, Qian Zhang, Hanxun Wang, Wenyu Xiu, Pu Xu, Yujie Deng, Wanxu Huang, Dan Ohtan Wang   +8 more
doaj   +1 more source

DNA repair in cancer: emerging targets for personalized therapy [PDF]

, 2014
Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA repair machinery to process DNA damage and maintain genomic integrity.
Abbotts, Rachel, Madhusudan, Srinivasan, Thompson, Nicola   +2 more
core   +3 more sources

PARP1 exhibits enhanced association and catalytic efficiency with γH2A.X-nucleosome

Nature Communications, 2019
The poly(ADP-ribose) polymerases play a key role in maintaining genomic integrity by detecting DNA damage and mediating repair. Here the authors characterize the kinetics of PARP1 binding to a variety of nucleosomes harbouring DNA double-strand breaks.
Deepti Sharma, Louis De Falco, Sivaraman Padavattan, Chang Rao, Susana Geifman-Shochat, Chuan-Fa Liu, Curt A. Davey   +6 more
doaj   +1 more source

Glycyrrhetinic acid and its derivatives as inhibitors of poly(ADP-ribose)polymerases 1 and 2, apurinic/apyrimidinic endonuclease 1 and DNA polymerase β [PDF]

, 2012
Aim. For strengthening the efficiency of monofunctional alkylating antineoplastic drugs it is important to lower the capacity of base excision repair (BER) system which corrects the majority of DNA damages caused by these reagents.
Ilina E. S., Khodyreva S. N., Kutuzov M. M., Lavrik O. I., Salakhutdinov N. F., Salomatina O. V., Schreiber V., Sukhanova M. V., Zakharenko A. L.   +8 more
core   +3 more sources

Structural Implications for Selective Targeting of PARPs. [PDF]

, 2013
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that use NAD(+) as a substrate to synthesize polymers of ADP-ribose (PAR) as post-translational modifications of proteins.
Armen, MD, Roger S, Brody, MD, Jonathan, Pascal, MD, John M, Steffen, MD, Jamin D   +3 more
core   +3 more sources