Results 1 to 10 of about 7,374 (163)

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells [version 2; referees: 2 approved]

F1000Research, 2016
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A. Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D. Waddell, Donald J. Ogilvie   +10 more
doaj   +2 more sources

Preparation and Self-Assembly of pH-Responsive Hyperbranched Polymer Peptide Hybrid Materials

Nanomaterials, 2023
In recent years, the coupling of structurally and functionally controllable polymers with biologically active peptide materials to obtain polymer-peptide hybrids with excellent properties and biocompatibility has led to important research progress in the
Yan Qin, Jianguo Yi, Yue Zhang
doaj   +1 more source

An assay to measure poly(ADP ribose) glycohydrolase (PARG) activity in cells [version 1; referees: 2 approved]

F1000Research, 2016
After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James, Stephen Durant, Kay Eckersley, Emma Fairweather, Louise A. Griffiths, Nicola Hamilton, Paul Kelly, Mark O'Connor, Kerry Shea, Ian D. Waddell, Donald J. Ogilvie   +10 more
doaj   +1 more source

Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. [PDF]

PLoS ONE, 2014
Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation.
Markus Dahl, Varun Maturi, Peter Lönn, Panagiotis Papoutsoglou, Agata Zieba, Michael Vanlandewijck, Lars P van der Heide, Yukihide Watanabe, Ola Söderberg, Michael O Hottiger, Carl-Henrik Heldin, Aristidis Moustakas   +11 more
doaj   +1 more source

Poly(ADP-Ribose) Glycohydrolase (PARG) vs. Poly(ADP-Ribose) Polymerase (PARP) – Function in Genome Maintenance and Relevance of Inhibitors for Anti-cancer Therapy

Frontiers in Molecular Biosciences, 2020
Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins.
Daniel Harrision, Polly Gravells, Ruth Thompson, Helen E. Bryant   +3 more
doaj   +1 more source

Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development

Scientific Reports, 2022
The transcriptome is subject to rapid and massive changes during the transition between developmental stages. These changes require tight control to avoid the undesired reactivation of gene expression that is only important for previous developmental ...
Guillaume Bordet, Iaroslava Karpova, Alexei V. Tulin   +2 more
doaj   +1 more source

DePARylation is critical for S phase progression and cell survival

eLife
Poly(ADP-ribose)ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation by poly(ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic regulation of DNA damage response.
Litong Nie, Chao Wang, Min Huang, Xiaoguang Liu, Xu Feng, Mengfan Tang, Siting Li, Qinglei Hang, Hongqi Teng, Xi Shen, Li Ma, Boyi Gan, Junjie Chen   +12 more
doaj   +1 more source

The interplay of TARG1 and PARG protects against genomic instability

Cell Reports, 2023
Summary: The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that removes aspartate/
Joséphine Groslambert, Evgeniia Prokhorova, Anne R. Wondisford, Callum Tromans-Coia, Celeste Giansanti, Jennifer Jansen, Gyula Timinszky, Matthias Dobbelstein, Dragana Ahel, Roderick J. O’Sullivan, Ivan Ahel   +10 more
doaj   +1 more source

Scaling up Sustainable Agriculture and Food Security With Nanoscience and Technology

Modern Agriculture
Agriculture has been the primary source of food for humanity since time immemorial. With the ever‐growing global population and the rising demand for food supplies, there has been a transition from traditional agricultural practices to more advanced ...
Goshen David Miteu, Olayemi Ojeokun, Irenosen Addeh, Afolabi Ayomide, Temidayo Olayinka, Sunday Godwin James, Oluwatobi Adeyemo, Elohozino Oghale Benneth   +7 more
doaj   +1 more source

A collection of pseudo-words to study multi-talker speech intelligibility without shifts of spatial attention

Frontiers in Psychology, 2012
A new collection of pseudo-words was recorded from a single female speaker of American English for use in multi-talker speech intelligibility research.
Kachina eAllen, David eAlais, Simon eCarlile   +2 more
doaj   +1 more source