Results 21 to 30 of about 6,727 (169)
Cancer Reports, 2023 Background Poly(ADP‐ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP‐ribose) (PAR) metabolism and a potential anticancer target. Many drug candidates have been developed to inhibit its enzymatic activity.
Kaede Tsuda +3 more
doaj +1 more source
Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control
Life Science Alliance, 2022 The phosphorylation of poly(ADP-risobyl) glycohydrolase is involved in stem-cells differentiation, embryonic/larval development, regulation of longevity and fertility by calorie restriction.
Guillaume Bordet +2 more
doaj +1 more source
Remote Sensing, 2019 Obtaining average canopy temperature (Tc) by thresholding canopy pixels from on-ground thermal imagery has historically been undertaken using ‘wet’ and ‘dry’ reference surfaces in the field (reference temperature thresholding ...
Arachchige Surantha Ashan Salgadoe +3 more
doaj +1 more source
Frontiers in Oncology, 2021 BackgroundPoly ADP-ribose glycohydrolase (PARG) is responsible for the catabolism of PARP-synthesized PAR to free ADP-ribose. Inhibition of PARG leads to DNA repair interruption and consequently induces cell death.
Emad Matanes +19 more
doaj +1 more source
BMC Cancer, 2022 Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fibroblasts, angiogenesis, metastasis, and ...
Sarah Johnson +5 more
doaj +1 more source
Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
Nature Communications, 2021 PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the ...
Johannes Gregor Matthias Rack +13 more
doaj +1 more source
PLoS ONE, 2016 Benzo(a)pyrene (BaP) is a ubiquitously distributed environmental pollutant and known carcinogen, which can induce malignant transformation in rodent and human cells.
Xuan Li +8 more
doaj +1 more source
The Road to Survival Goes through PARG [PDF]
Cell Cycle, 2005 Unlike poly(ADP-ribose) polymerase-1 (PARP-1), poly(ADP-ribose) glycohydrolase (PARG) has long been a difficult protein to study. However, the complete absence of PARG activity was recently characterized in mice via disruption of the murine PARG gene. As expected, PARG is critical for the maintenance of steady-state poly(ADP-ribose) levels.
David W, Koh +2 more
openaire +2 more sources
Preparation and Self-Assembly of pH-Responsive Hyperbranched Polymer Peptide Hybrid Materials
Nanomaterials, 2023 In recent years, the coupling of structurally and functionally controllable polymers with biologically active peptide materials to obtain polymer-peptide hybrids with excellent properties and biocompatibility has led to important research progress in the
Yan Qin, Jianguo Yi, Yue Zhang
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F1000Research, 2016 After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James +10 more
doaj +1 more source