Elevated TRIM25 Impairs Poly (ADP-ribose) Metabolism via PARG Degradation and Mediates Compression-Induced Intervertebral Disc Degeneration. [PDF]
Adv Sci (Weinh)TRIM25 acts as a multifunctional hub driving intervertebral disc degeneration under mechanical stress. Mechanical compression significantly upregulates TRIM25 expression, establishing it as a key E3 ubiquitin ligase platform. TRIM25 targets PARG and Ku80 via distinct molecular interfaces, triggering their ubiquitination and degradation.
Cheng Z +9 more
europepmc +2 more sources
PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks
Nature CommunicationsDNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular level to exert TMEJ remains poorly characterized. We find that Polθ interacts with
Umeshkumar Vekariya +12 more
doaj +2 more sources
Science in One Health, 2023 Nanoscience and technology have shown promise in revitalizing the agricultural sector and industries. This tool has gained the interest of many researchers as it can be utilized to drive sustainable agriculture by suggesting long-lasting solutions to ...
Goshen David Miteu +7 more
doaj +1 more source
Crystallographic and biochemical analysis of the mouse poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2014 Protein poly(ADP-ribosyl)ation (PARylation) regulates a number of important cellular processes. Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme responsible for hydrolyzing the poly(ADP-ribose) (PAR) polymer in vivo.
Zhizhi Wang +3 more
doaj +1 more source
Benefits and barriers to physical activity among African women: A systematic review
Sports Medicine and Health Science, 2023 Black women have always been likened to being a less physically active group compared to women of other races/ethnicity, with reports of a high prevalence of obesity and other cardiometabolic diseases among them.
Ogechi Christiana Obi +3 more
doaj +1 more source
Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2009 The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell signaling functions. In addition, extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a dominant cause of cell death in ...
David M Burns +4 more
doaj +1 more source
Structures of the human poly (ADP-ribose) glycohydrolase catalytic domain confirm catalytic mechanism and explain inhibition by ADP-HPD derivatives. [PDF]
PLoS ONE, 2012 Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
Julie A Tucker +9 more
doaj +1 more source
Cancer Reports, 2023 Background Poly(ADP‐ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP‐ribose) (PAR) metabolism and a potential anticancer target. Many drug candidates have been developed to inhibit its enzymatic activity.
Kaede Tsuda +3 more
doaj +1 more source
Immunoexpression of PARG in different endometrial specimen
, 2023 Figure 1: Immunoexpression of PARG in different endometrial specimen: Positive expression of PARG in normal endometrium from proliferative phase, positive expression of PARG in normal endometrium from secretory phase, positive expression of PARG in ...
Yanyan Sun (14315014)
core +1 more source
Poly(ADP-ribosyl)ating pathway regulates development from stem cell niche to longevity control
Life Science Alliance, 2022 The phosphorylation of poly(ADP-risobyl) glycohydrolase is involved in stem-cells differentiation, embryonic/larval development, regulation of longevity and fertility by calorie restriction.
Guillaume Bordet +2 more
doaj +1 more source