Results 31 to 40 of about 7,374 (163)

Prospects for PARG inhibitors in cancer therapy [PDF]

Journal of Molecular Cell Biology
Zu Ye, Ji Jing, Ye Zu
exaly   +2 more sources

A Non-Reference Temperature Histogram Method for Determining T_c from Ground-Based Thermal Imagery of Orchard Tree Canopies

Remote Sensing, 2019
Obtaining average canopy temperature (Tc) by thresholding canopy pixels from on-ground thermal imagery has historically been undertaken using ‘wet’ and ‘dry’ reference surfaces in the field (reference temperature thresholding ...
Arachchige Surantha Ashan Salgadoe, Andrew James Robson, David William Lamb, Derek Schneider   +3 more
doaj   +1 more source

Inhibition of Poly ADP-Ribose Glycohydrolase Sensitizes Ovarian Cancer Cells to Poly ADP-Ribose Polymerase Inhibitors and Platinum Agents

Frontiers in Oncology, 2021
BackgroundPoly ADP-ribose glycohydrolase (PARG) is responsible for the catabolism of PARP-synthesized PAR to free ADP-ribose. Inhibition of PARG leads to DNA repair interruption and consequently induces cell death.
Emad Matanes, Emad Matanes, Vanessa M. López-Ozuna, David Octeau, Tahira Baloch, Florentin Racovitan, Amandeep Kaur Dhillon, Roy Kessous, Roy Kessous, Oded Raban, Oded Raban, Liron Kogan, Liron Kogan, Shannon Salvador, Shannon Salvador, Susie Lau, Susie Lau, Walter H. Gotlieb, Walter H. Gotlieb, Amber Yasmeen   +19 more
doaj   +1 more source

Reduced Tumorigenicity of Mouse ES Cells and the Augmented Anti-Tumor Therapeutic Effects under Parg Deficiency [PDF]

, 2020
PolyADP-ribosylation is a post-translational modification of proteins, and poly(ADP-ribose) (PAR) polymerase (PARP) family proteins synthesize PAR using NAD as a substrate.
Yuki Sonoda, Masutani, Mitsuko, Honda, Takuya, Shoji Imamichi, Tomonori Araki, Araki, Tomonori, Takuya Honda, Sasaki, Yuka, Yuka Sasaki, Anna-Margareta Rydén, Watanabe, Masatoshi, Jun Itami, Mitsuko Masutani, Nakao, Kazuhiko, Kazuhiko Nakao, Shirai, Hidenori, Itami, Jun, Takae Onodera, Imamichi, Shoji, Rydén, Anna-Margareta, Masatoshi Watanabe, Kazuto Ashizawa, Onodera, Takae, Hidenori Shirai, Sonoda, Yuki, Gunji, Akemi, Akemi Gunji, Ashizawa, Kazuto   +27 more
core   +1 more source

PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment

BMC Cancer, 2022
Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fibroblasts, angiogenesis, metastasis, and ...
Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin   +5 more
doaj   +1 more source

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

Nature Communications, 2021
PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the ...
Johannes Gregor Matthias Rack, Qiang Liu, Valentina Zorzini, Jim Voorneveld, Antonio Ariza, Kourosh Honarmand Ebrahimi, Julia M. Reber, Sarah C. Krassnig, Dragana Ahel, Gijsbert A. van der Marel, Aswin Mangerich, James S. O. McCullagh, Dmitri V. Filippov, Ivan Ahel   +13 more
doaj   +1 more source

Pharmacological characterisation of novel, cell active, inhibitors of Poly(ADP-ribose glycohydrolase (PARG)

, 2014
Poly(ADP-ribose) glycohydrolase (PARG) is the only enzyme known to catalyse hydrolysis of the O-glycosidic linkages of ADP-ribose polymers, thereby reversing the effects of poly(ADP-ribose) polymerases.
James, Dominic, Stowell, Alexandra, Waddell, Ian, Smith, Kate, Jordan, Allan, Hamilton, Nicola, Waszkowycz, Bohdan, McGonagle, Alison, Ogilvie, Donald   +8 more
core   +3 more sources

Nuclear PARG protein expression is reduced by the PARG antisense PMO targeted to exon 1.

, 2013
(A) The full-length 111 kD protein contains a nuclear localization sequence (NLS) in exon 1 and a nuclear export sequence (NES) near the carboxy terminus. The anti-PARG antibody targets the peptide fragment indicated [27].
David M. Burns (373781), Tiina M. Kauppinen (373783), Raymond A. Swanson (373785), Keqing Zhu (304790), Weihai Ying (349430)   +4 more
core   +1 more source

Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues

Advanced NanoBiomed Research, EarlyView.
Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt, Shahrzad Rokhsary, Linus Hübner, Lea Miebach, Sander Bekeschus   +4 more
wiley   +1 more source

Quantifying the Severity of Phytophthora Root Rot Disease in Avocado Trees Using Image Analysis

Remote Sensing, 2018
Phytophthora root rot (PRR) infects the roots of avocado trees, resulting in reduced uptake of water and nutrients, canopy decline, defoliation, and, eventually, tree mortality.
Arachchige Surantha Ashan Salgadoe, Andrew James Robson, David William Lamb, Elizabeth Kathryn Dann, Christopher Searle   +4 more
doaj   +1 more source