Results 31 to 40 of about 6,727 (169)
PARP and PARG inhibitors in cancer treatment [PDF]
Genes & Development, 2020 Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying genomic instability through radiotherapy and chemotherapy has been a powerful but nonselective means of killing cancer cells. Precision medicine has revolutionized cancer therapy by putting forth the concept of selective targeting of cancer cells. Poly(ADP-ribose)
openaire +2 more sources
Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. [PDF]
PLoS ONE, 2014 Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation.
Markus Dahl +11 more
doaj +1 more source
Frontiers in Molecular Biosciences, 2020 Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins.
Daniel Harrision +3 more
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Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development
Scientific Reports, 2022 The transcriptome is subject to rapid and massive changes during the transition between developmental stages. These changes require tight control to avoid the undesired reactivation of gene expression that is only important for previous developmental ...
Guillaume Bordet +2 more
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DePARylation is critical for S phase progression and cell survival
eLifePoly(ADP-ribose)ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation by poly(ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic regulation of DNA damage response.
Litong Nie +12 more
doaj +1 more source
F1000Research, 2016 After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James +10 more
doaj +1 more source
Scaling up Sustainable Agriculture and Food Security With Nanoscience and Technology
Modern AgricultureAgriculture has been the primary source of food for humanity since time immemorial. With the ever‐growing global population and the rising demand for food supplies, there has been a transition from traditional agricultural practices to more advanced ...
Goshen David Miteu +7 more
doaj +1 more source
Frontiers in Psychology, 2012 A new collection of pseudo-words was recorded from a single female speaker of American English for use in multi-talker speech intelligibility research.
Kachina eAllen +2 more
doaj +1 more source
Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues
Advanced NanoBiomed Research, EarlyView.Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt +4 more
wiley +1 more source
Quantifying the Severity of Phytophthora Root Rot Disease in Avocado Trees Using Image Analysis
Remote Sensing, 2018 Phytophthora root rot (PRR) infects the roots of avocado trees, resulting in reduced uptake of water and nutrients, canopy decline, defoliation, and, eventually, tree mortality.
Arachchige Surantha Ashan Salgadoe +4 more
doaj +1 more source