Results 31 to 40 of about 6,989 (168)
Preparation and Self-Assembly of pH-Responsive Hyperbranched Polymer Peptide Hybrid Materials
Nanomaterials, 2023 In recent years, the coupling of structurally and functionally controllable polymers with biologically active peptide materials to obtain polymer-peptide hybrids with excellent properties and biocompatibility has led to important research progress in the
Yan Qin, Jianguo Yi, Yue Zhang
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PARP and PARG inhibitors in cancer treatment [PDF]
Genes & Development, 2020 Oxidative and replication stress underlie genomic instability of cancer cells. Amplifying genomic instability through radiotherapy and chemotherapy has been a powerful but nonselective means of killing cancer cells. Precision medicine has revolutionized cancer therapy by putting forth the concept of selective targeting of cancer cells. Poly(ADP-ribose)
openaire +2 more sources
Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. [PDF]
PLoS ONE, 2014 Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation.
Markus Dahl +11 more
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DePARylation is critical for S phase progression and cell survival
eLifePoly(ADP-ribose)ylation or PARylation by PAR polymerase 1 (PARP1) and dePARylation by poly(ADP-ribose) glycohydrolase (PARG) are equally important for the dynamic regulation of DNA damage response.
Litong Nie +12 more
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F1000Research, 2016 After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James +10 more
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Frontiers in Molecular Biosciences, 2020 Poly(ADP-ribose) polymerases (PARPs) are a family of enzymes that catalyze the addition of poly(ADP-ribose) (PAR) subunits onto themselves and other acceptor proteins.
Daniel Harrision +3 more
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Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development
Scientific Reports, 2022 The transcriptome is subject to rapid and massive changes during the transition between developmental stages. These changes require tight control to avoid the undesired reactivation of gene expression that is only important for previous developmental ...
Guillaume Bordet +2 more
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Scaling up Sustainable Agriculture and Food Security With Nanoscience and Technology
Modern AgricultureAgriculture has been the primary source of food for humanity since time immemorial. With the ever‐growing global population and the rising demand for food supplies, there has been a transition from traditional agricultural practices to more advanced ...
Goshen David Miteu +7 more
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Frontiers in Psychology, 2012 A new collection of pseudo-words was recorded from a single female speaker of American English for use in multi-talker speech intelligibility research.
Kachina eAllen +2 more
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Oppositely Charged Homopolypeptides Form Ordered Helix Assemblies With Hierarchical Structure
Small, EarlyView.Hexagaonal and square assembly of polyarginine alfa‐helices formed in highly ordered polyarginine/polyaspartic acid complexes. The helices exhibit additional periodic staggering along their helical axis. ABSTRACT Oppositely charged polyelectrolytes are known to form polyelectrolyte complexes.
Ekaterina Buvalaia +10 more
wiley +1 more source