PLoS ONE, 2016 Benzo(a)pyrene (BaP) is a ubiquitously distributed environmental pollutant and known carcinogen, which can induce malignant transformation in rodent and human cells.
Xuan Li +8 more
doaj +1 more source
Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal
Nature Communications, 2021 PARG and ARH3 are the main hydrolases to reverse serine poly(ADP-ribosylation) yet their activities in the process differ. Here, the authors synthesise linear and branched poly(ADP-ribose) molecules, perform structure-function analysis and elucidate the ...
Johannes Gregor Matthias Rack +13 more
doaj +1 more source
Radiosensitization with an inhibitor of poly(ADP-ribose) glycohydrolase: A comparison with the PARP1/2/3 inhibitor olaparib [PDF]
, 2018 Upon DNA binding the poly(ADP-ribose) polymerase family of enzymes (PARPs) add multiple ADP-ribose subunits to themselves and other acceptor proteins.
Albert +94 more
core +2 more sources
Cellular bases of the RNA metabolism dysfunction in motor neurons of a murine model of spinal muscular atrophy: Role of Cajal bodies and the nucleolus [PDF]
, 2017 Spinal muscular atrophy (SMA) is caused by a homozygous deletion or mutation in the survival motor neuron 1 (SMN1) gene that leads to reduced levels of SMN protein resulting in degeneration of motor neurons (MNs).
Berciano, Maria T. +7 more
core +2 more sources
Preparation and Self-Assembly of pH-Responsive Hyperbranched Polymer Peptide Hybrid Materials
Nanomaterials, 2023 In recent years, the coupling of structurally and functionally controllable polymers with biologically active peptide materials to obtain polymer-peptide hybrids with excellent properties and biocompatibility has led to important research progress in the
Yan Qin, Jianguo Yi, Yue Zhang
doaj +1 more source
F1000Research, 2016 After a DNA damage signal multiple polymers of ADP ribose attached to poly(ADP) ribose (PAR) polymerases (PARPs) are broken down by the enzyme poly(ADP) ribose glycohydrolase (PARG).
Dominic I. James +10 more
doaj +1 more source
Fine-tuning of Smad protein function by poly(ADP-ribose) polymerases and poly(ADP-ribose) glycohydrolase during transforming growth factor β signaling. [PDF]
PLoS ONE, 2014 Initiation, amplitude, duration and termination of transforming growth factor β (TGFβ) signaling via Smad proteins is regulated by post-translational modifications, including phosphorylation, ubiquitination and acetylation.
Markus Dahl +11 more
doaj +1 more source
Methylation status of Dnmt1 promoter depends on poly(ADP-ribosy)lation [PDF]
, 2007 Research is focused on CpG islands and on the mechanism that poly(ADP-ribosyl)ation uses to defend the unmethylated state of these important DNA sequences which are located in the promoter regions of the housekeeping genes having a role of transcription ...
Zampieri, Michele
core +1 more source
Poly(ADP-ribosyl)ating enzymes cooperate to coordinate development
Scientific Reports, 2022 The transcriptome is subject to rapid and massive changes during the transition between developmental stages. These changes require tight control to avoid the undesired reactivation of gene expression that is only important for previous developmental ...
Guillaume Bordet +2 more
doaj +1 more source
Purification of Recombinant Human PARG and Activity Assays [PDF]
, 2017 The purification of Poly(ADP-ribose) glycohydrolase (PARG) from overexpressing bacteria Escherichia coli is described here to a fast and reproducible one chromatographic step protocol. After cell lysis, GST-PARG-fusion proteins from the crude extract are affinity purified by a Glutathione 4B Sepharose chromatographic step.
Amé, Jean-Christophe +4 more
openaire +2 more sources