Results 51 to 60 of about 7,374 (163)

A novel non-canonical PIP-box mediates PARG interaction with PCNA

, 2017
Poly(ADP-ribose) glycohydrolase (PARG) regulates cellular poly(ADP-ribose) (PAR) levels by rapidly cleaving glycosidic bonds between ADP-ribose units. PARG interacts with proliferating cell nuclear antigen (PCNA) and is strongly recruited to DNA damage ...
Kaufmann, Tanja (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Grishkovskaya, Irina (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Zagrovic, Bojan (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Kukolj, Eva (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Herbert, Sebastien (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Peterbauer, Thomas (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Zhang, Lijuan (VBCF-Advanced Microscopy, Vienna Biocenter (VBC)), Gotzmann, Josef (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Hartl, Markus (Large-Instrument Facility for Mass Spectrometry in Life Sciences, Faculty of Life Sciences, University of Vienna), Beltzung, Etienne (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Slade, Dea (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Mechtler, Karl (Institute of Molecular Pathology, Vienna Biocenter (VBC)), Elsayad, Kareem (VBCF-Advanced Microscopy, Vienna Biocenter (VBC)), Polyansky, Anton A. (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Olek, Karin M. (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna), Djinovic-Carugo, Kristina (Department of Structural and Computational Biology, Centre for Molecular Biology, University of Vienna), Kostrhon, Sebastian (Department of Biochemistry and Cell Biology, Centre for Molecular Biology, University of Vienna)   +16 more
core   +2 more sources

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer

Journal for ImmunoTherapy of Cancer
Background Ovarian cancer is the most lethal gynecological malignancy, with limited treatment options after failure of standard therapies. Despite the potential of poly(ADP-ribose) polymerase inhibitors in treating DNA damage response (DDR)-deficient ...
Lorna Rodriguez-Rodriguez, Rui Huang, Mihaela Cristea, Qianqian Zhao, Adrian Kohut, Hua Yu, Mihae Song, Antons Martincuks, Chunyan Zhang, Edward W Wang, Theresa Austria, Yi-Jia Li, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Binghui Shen   +14 more
doaj   +1 more source

A multi‐network approach to assess how physical templates shape stream fish ecological strategies

Ecological Solutions and Evidence, Volume 7, Issue 2, April–June 2026.
This multi‐network framework identifies a continuous topological gradient of fish ecological strategies—comprising Dispersal Gateways, Integrated Connectors, and Mass Effect Dominated species—within the dendritic river template. The functional role of stream reaches is scale‐sensitive, particularly at headwater extremes where sites operate as critical ...
Mauricio Cetra, Rodrigo da Silva Almeida
wiley   +1 more source

Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

Translational Oncology, 2022
The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear.
Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li   +4 more
doaj   +1 more source

Insects and non‐woody plants slow down tropical forest succession: A community‐wide experiment in Papua New Guinea

Journal of Ecology, Volume 114, Issue 4, April 2026.
The importance of top‐down insect herbivory decreased, while the importance of bottom‐up plant competition with non‐woody plant species increased with elevation, representing a gradient of increasing environmental stress in the succession of woody plants.
Kari Sogera Iamba, Piotr Szefer, Kenneth Molem, Austin Sau, Gibson Maiah, Vojtech Novotny   +5 more
wiley   +1 more source

PARG INHIBITORY COMPOUNDS

, 2016
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity: wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein.
Waszkowycz,, Bohdan, Hutton, Colin, Waddell, Ian, Smith, Kate, Jordan, Allan, Hitchin, James, Hamilton, Niall, Mcgonagle, Alison   +7 more
core   +1 more source

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, Volume 20, Issue 3, Page 779-803, March 2026.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents

Neoplasia: An International Journal for Oncology Research
The ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown.
Rocco Caggiano, Evgeniia Prokhorova, Lena Duma, Kira Schützenhofer, Raffaella Lauro, Giuliana Catara, Rosa Marina Melillo, Angela Celetti, Rebecca Smith, S John Weroha, Scott H Kaufmann, Ivan Ahel, Luca Palazzo   +12 more
doaj   +1 more source

Molecular Insights into Poly(ADP-ribose) Recognition and Processing

Biomolecules, 2012
Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel, Eva Barkauskaite, Roko Žaja, Andreja Mikoč   +3 more
doaj   +1 more source