Results 61 to 70 of about 12,704 (204)

Recruitment of the ParG Segregation Protein to Different Affinity DNA Sites [PDF]

Journal of Bacteriology, 2009
ABSTRACTThe segrosome is the nucleoprotein complex that mediates accurate plasmid segregation. In addition to its multifunctional role in segrosome assembly, the ParG protein of multiresistance plasmid TP228 is a transcriptional repressor of theparFGpartition genes.
Zampini, Massimiliano, Derome, Andrew, Bailey, Simon E S, Barillà, Daniela, Hayes, Finbarr   +4 more
openaire   +3 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, Volume 20, Issue 3, Page 779-803, March 2026.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Targeting PARG induces tumor cell growth inhibition and antitumor immune response by reducing phosphorylated STAT3 in ovarian cancer

Journal for ImmunoTherapy of Cancer
Background Ovarian cancer is the most lethal gynecological malignancy, with limited treatment options after failure of standard therapies. Despite the potential of poly(ADP-ribose) polymerase inhibitors in treating DNA damage response (DDR)-deficient ...
Lorna Rodriguez-Rodriguez, Rui Huang, Mihaela Cristea, Qianqian Zhao, Adrian Kohut, Hua Yu, Mihae Song, Antons Martincuks, Chunyan Zhang, Edward W Wang, Theresa Austria, Yi-Jia Li, Nicole Lugo Santiago, Rosemarie Martinez Borrero, Binghui Shen   +14 more
doaj   +1 more source

Nicaraven induces programmed cell death by distinct mechanisms according to the expression levels of Bcl-2 and poly (ADP-ribose) glycohydrolase in cancer cells

Translational Oncology, 2022
The PARP-1 expression level and poly (ADP-ribosyl)ation activity in cancer markedly affect the therapeutic outcome. Nicaraven, a free radical scavenger has been found to inhibit PARP, but the effect on cancer cells is still unclear.
Lina Abdelghany, Tsuyoshi Kawabata, Shinji Goto, Keiichi Jingu, Tao-Sheng Li   +4 more
doaj   +1 more source

Poly(ADP-ribose)glycohydrolase is an upstream regulator of Ca2+ fluxes in oxidative cell death [PDF]

, 2018
Oxidative DNA damage to cells activates poly(ADP-ribose)polymerase-1 (PARP-1) and the poly(ADP-ribose) formed is rapidly degraded to ADP-ribose by poly(ADP-ribose)glycohydrolase (PARG).
Althaus, Felix, Bader, J., Blenn, C., Bollhalder, M., Wyrsch, P.   +4 more
core  

A topological characterization of the Moufang property for compact polygons

, 2016
We prove a purely topological characterization of the Moufang property for disconnected compact polygons in terms of convergence groups. As a consequence, we recover the fact that a locally finite thick affine building of rank 3 is a Bruhat-Tits building
Radu, Nicolas
core   +1 more source

Update on Poly-ADP-ribose polymerase inhibition for ovarian cancer treatment [PDF]

, 2016
Background: Despite standard treatment for epithelial ovarian cancer (EOC), that involves cytoreductive surgery followed by platinum-based chemotherapy, and initial high response rates to these, up to 80 % of patients experience relapses with a median ...
Caruso, Davide, Papa, Anselmo, Strudel, Martina, Tomao, Federica, Tomao, Silverio   +4 more
core   +2 more sources

Poly (ADP-ribose) glycohydrolase (PARG) and its therapeutic potential

Frontiers in Bioscience, 2009
Poly (ADP-robose) glycohydrolase (PARG) is a catabolic enzyme that cleaves ADP-ribose polymers synthesized by members of the poly (ADP-ribose) polymerase (PARP) family of enzymes. The growing evidence supports the importance of a tight control of poly (ADP-ribose) metabolism by the two major enzymes, PARP-1 and PARG.
Wookee, Min, Zhao-Qi, Wang
openaire   +2 more sources

Longitudinal association between sleep and Alzheimer's pathology

Alzheimer's &Dementia, Volume 22, Issue 3, March 2026.
Abstract INTRODUCTION Since sleep disturbance is a modifiable risk factor for Alzheimer's disease (AD), we tested associations between sleep and AD pathology in cognitively unimpaired (CU) persons. METHODS We included 223 participants from the PREVENT‐AD cohort with self‐reported measures of sleep, objective actigraphy measures of sleep, and positron ...
Bery Mohammediyan, Andrée‐Ann Baril, Alfonso Fajardo Valdez, Frédéric St‐Onge, Alexa Pichet Binette, Julie Carrier, Maiya R. Geddes, Simon Ducharme, Maxime Montembeault, Jean‐Paul Soucy, John Breitner, Judes Poirier, Sylvia Villeneuve, for the PREVENT‐AD Research Group   +13 more
wiley   +1 more source

Southern Hemisphere automated supernova search [PDF]

, 1995
The Perth Astronomy Research Group has developed an automated supernova search program, using the 61 cm Perth–Lowell reflecting telescope at Perth Observatory in Western Australia, equipped with a CCD camera.
Blair, D.G., Burman, R., Koch, R., Lynch, M.J., Martin, R., Verveer, A., Williams, A.J.   +6 more
core   +2 more sources