Results 61 to 70 of about 6,989 (168)

Molecular Insights into Poly(ADP-ribose) Recognition and Processing

Biomolecules, 2012
Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel, Eva Barkauskaite, Roko Žaja, Andreja Mikoč   +3 more
doaj   +1 more source

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

The FEBS Journal, Volume 293, Issue 11, Page 3274-3287, June 2026.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar, Albert Galera‐Prat, Jin Cai, Julia Preisser, Tiila‐Riikka Kiema, Andreas Ladurner, Lari Lehtiö   +6 more
wiley   +1 more source

Recruitment of the ParG Segregation Protein to Different Affinity DNA Sites [PDF]

Journal of Bacteriology, 2009
ABSTRACTThe segrosome is the nucleoprotein complex that mediates accurate plasmid segregation. In addition to its multifunctional role in segrosome assembly, the ParG protein of multiresistance plasmid TP228 is a transcriptional repressor of theparFGpartition genes.
Zampini, Massimiliano, Derome, Andrew, Bailey, Simon E S, Barillà, Daniela, Hayes, Finbarr   +4 more
openaire   +3 more sources

The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase

Molecules, 2011
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action.
Felix R. Althaus, Philippe Wyrsch, Christian Blenn   +2 more
doaj   +1 more source

Real‐World Effectiveness and Safety of Pegzilarginase Treatment in Arginase 1 Deficiency

JIMD Reports, Volume 67, Issue 3, May 2026.
ABSTRACT Pegzilarginase is the first disease‐modifying drug for arginase 1 deficiency. In clinical trials, pegzilarginase effectively normalised plasma arginine (pArg), which was associated with clinically relevant improvements in neuromotor outcomes. We report from a French early access scheme the first report on experience from pegzilarginase therapy
Anaïs Brassier, Alina Arion, Jean‐Baptiste Arnoux, Magalie Barth, Dries Dobbelaere, Magali Gorce, Michael Grövdal, Cécile Laroche, Olivia Rime, Manuel Schiff, Mattias Rudebeck   +10 more
wiley   +1 more source

Targeting Tumor Stroma: Current Challenges and Future Directions

MedComm, Volume 7, Issue 5, May 2026.
Figure 1. Mechanism of ECM reprogramming. Cancer‐associated fibroblasts (CAFs), cancer‐associated macrophages (CAMs), and other mesenchymal cells alter the ECM composition and increase its stiffness by depositing matrix components such as collagen and hyaluronic acid, and secreting cross‐linking agents like lysyl oxidase homolog 2 (LOXL2).
Siwei Wang, Haofan Hu, Weifeng Zeng, Lu Qin, Xiaoping Chen, Zhibin Liao, Furong Liu, Zhanguo Zhang   +7 more
wiley   +1 more source

Prospects for PARG inhibitors in cancer therapy

Journal of Molecular Cell Biology
Abstract Poly(ADP-ribose) glycosylhydrolase (PARG) is an enzyme involved in hydrolyzing the ribose–ribose bonds present in poly(ADP-ribose) (PAR), which are primarily found in the nucleus. Along with poly(ADP-ribose) polymerase, PARG regulates the level of PAR in cells, playing a crucial role in DNA maintenance and repair processes ...
Yangchan Hu, Yuxin Meng, Zirui Zhuang, Yuancong Li, Junjun Nan, Ning Xu, Zu Ye, Ji Jing   +7 more
openaire   +2 more sources

A multi‐network approach to assess how physical templates shape stream fish ecological strategies

Ecological Solutions and Evidence, Volume 7, Issue 2, April–June 2026.
This multi‐network framework identifies a continuous topological gradient of fish ecological strategies—comprising Dispersal Gateways, Integrated Connectors, and Mass Effect Dominated species—within the dendritic river template. The functional role of stream reaches is scale‐sensitive, particularly at headwater extremes where sites operate as critical ...
Mauricio Cetra, Rodrigo da Silva Almeida
wiley   +1 more source

PARP1 gene expression is downregulated by knockdown of PARG gene

Oncology Reports, 2013
Poly(ADP-ribosyl)ation is a modification of nuclear proteins that regulates DNA replication, repair and transcription. In order to investigate the biological effects of degradation of poly(ADP-ribose), knockdown of the poly(ADP-ribose) glycohydrolase (PARG) gene was performed by introducing a short interfering RNA (siRNA)-pool into HeLa S3 cells ...
UCHIUMI, FUMIAKI, WATANABE, TAKESHI, OHTA, RYO, ABE, HIDEAKI, TANUMA, SEI-ICHI   +4 more
openaire   +3 more sources

Abstracts

Molecular Oncology, Volume 20, Issue S1, Page 1-692, August 2026.
Abstracts submitted to the ‘EACR 2026 Congress: Innovative Cancer Science’, from 08–11 June 2026 and accepted by the Congress Organising Committee are published in this Supplement of Molecular Oncology, an affiliated journal of the European Association for Cancer Research (EACR).
wiley   +1 more source