Results 61 to 70 of about 6,727 (169)
iMetaOmics, Volume 3, Issue 1, March 2026.Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo +9 more
wiley +1 more source
The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase
Molecules, 2011 DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action.
Felix R. Althaus +2 more
doaj +1 more source
Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Arginase 1 deficiency (ARG1‐D) is an ultra‐rare inherited metabolic disorder of the urea cycle, caused by partial or complete loss of arginase 1 function, characterised by hyperargininaemia and a distinct, progressive neurological phenotype. The clinical development programme of pegzilarginase, a recombinant human ARG1 enzyme therapy, provides
Mattias Rudebeck +10 more
wiley +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT Our previous studies have demonstrated that seven in absentia homologue 1 (SIAH1), an E3 ubiquitin ligase, is downregulated in hepatocellular carcinoma (HCC) and regulates substrate ubiquitination. However, the molecular mechanisms governing reduced SIAH1 expression in HCC remain unclear.
Jie Qiu +6 more
wiley +1 more source
Pharmaceutics, 2020 Tuberculosis (TB) is the leading cause of death from a single infectious microorganism and Bacillus Calmette Guerin (BCG), the only authorized vaccine, does not confer protection against pulmonary TB. Based on the hypothesis that mucosal protection could
Lara Diego-González +7 more
doaj +1 more source
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source
Pharmaceutics, 2020 Microencapsulation and targeted delivery of cytotoxic and antibacterial agents of photodynamic therapy (PDT) improve the treatment outcomes for infectious diseases and cancer.
Alexey V. Ermakov +9 more
doaj +1 more source
Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development
Advanced Science, Volume 13, Issue 7, 3 February 2026.Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong +21 more
wiley +1 more source
Advanced Science, Volume 12, Issue 47, December 18, 2025.This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang +8 more
wiley +1 more source
PARP1 gene expression is downregulated by knockdown of PARG gene
Oncology Reports, 2013 Poly(ADP-ribosyl)ation is a modification of nuclear proteins that regulates DNA replication, repair and transcription. In order to investigate the biological effects of degradation of poly(ADP-ribose), knockdown of the poly(ADP-ribose) glycohydrolase (PARG) gene was performed by introducing a short interfering RNA (siRNA)-pool into HeLa S3 cells ...
UCHIUMI, FUMIAKI +4 more
openaire +3 more sources