Results 71 to 80 of about 12,704 (204)
iMetaOmics, Volume 3, Issue 1, March 2026.Estuaries are vital hotspots for antibiotic resistance genes (ARGs) due to substantial antibiotic pollution. Although viruses have been proposed as key reservoirs and important disseminators of ARGs in environments, their contribution to the estuarine antibiotic resistome remains largely unknown.
Xiao‑Qing Luo +9 more
wiley +1 more source
Suppression of ADP-ribosylation reversal triggers cell vulnerability to alkylating agents
Neoplasia: An International Journal for Oncology ResearchThe ADP-ribosyl hydrolases PARG and ARH3 counteract PARP enzymatic activity by removing ADP-ribosylation. PARG and ARH3 activities have a synthetic lethal effect; however, the specific molecular mechanisms underlying this response remain unknown.
Rocco Caggiano +12 more
doaj +1 more source
Disrupted ADP-ribose metabolism with nuclear Poly (ADP-ribose) accumulation leads to different cell death pathways in presence of hydrogen peroxide in procyclic Trypanosoma brucei [PDF]
, 2016 TbPARG in Trypanosoma brucei. A) TbPARG localization in untreated (control) and in procyclic cultures exposed to 500 μM H2O2 for 10 min. IFI was carried out as reported in our previous work [33].
Harikanth Venkannagari +7 more
core +6 more sources
Journal of Inherited Metabolic Disease, Volume 49, Issue 2, March 2026.ABSTRACT Arginase 1 deficiency (ARG1‐D) is an ultra‐rare inherited metabolic disorder of the urea cycle, caused by partial or complete loss of arginase 1 function, characterised by hyperargininaemia and a distinct, progressive neurological phenotype. The clinical development programme of pegzilarginase, a recombinant human ARG1 enzyme therapy, provides
Mattias Rudebeck +10 more
wiley +1 more source
Molecular Insights into Poly(ADP-ribose) Recognition and Processing
Biomolecules, 2012 Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel +3 more
doaj +1 more source
The Variable Markov Oracle: Algorithms for Human Gesture Applications [PDF]
, 2015 This article introduces the Variable Markov Oracle (VMO) data structure for multivariate time series indexing. VMO can identify repetitive fragments and find sequential similarities between observations.
Dubnov, Shlomo, Wang, Cheng-i
core +1 more source
Journal of Cellular and Molecular Medicine, Volume 30, Issue 6, March 2026.ABSTRACT Our previous studies have demonstrated that seven in absentia homologue 1 (SIAH1), an E3 ubiquitin ligase, is downregulated in hepatocellular carcinoma (HCC) and regulates substrate ubiquitination. However, the molecular mechanisms governing reduced SIAH1 expression in HCC remain unclear.
Jie Qiu +6 more
wiley +1 more source
Partial and global representations of finite groups
, 2020 Given a subgroup H of a finite group G, we begin a systematic study of the partial representations of G that restrict to global representations of H.
D'Adderio, Michele +3 more
core
PARP-1 regulates DNA repair factor availability. [PDF]
, 2018 PARP-1 holds major functions on chromatin, DNA damage repair and transcriptional regulation, both of which are relevant in the context of cancer. Here, unbiased transcriptional profiling revealed the downstream transcriptional profile of PARP-1 enzymatic
Birbe, Ruth +31 more
core +2 more sources
Polo‐like kinases and UV‐induced skin carcinogenesis: What we know and what's next
Photochemistry and Photobiology, Volume 102, Issue 2, Page 276-289, March/April 2026.The polo‐like kinase (PLK) family plays distinct and critical roles in the regulation of cell cycle progression, and its dysregulation has been implicated in various cancers. Ultraviolet (UV) radiation is a well‐established environmental factor in the development of skin cancer.
Tanya Jaiswal +3 more
wiley +1 more source