Results 71 to 80 of about 7,374 (163)
Pharmaceutics, 2020 Microencapsulation and targeted delivery of cytotoxic and antibacterial agents of photodynamic therapy (PDT) improve the treatment outcomes for infectious diseases and cancer.
Alexey V. Ermakov +9 more
doaj +1 more source
Advanced Science, Volume 12, Issue 47, December 18, 2025.This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang +8 more
wiley +1 more source
PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency
, 2016 BACKGROUND: Poly(ADP-ribose) polymerase (PARP) inhibitors have entered the clinics for their promising anticancer effect as adjuvant in chemo- and radiotherapy and as single agent on BRCA-mutated tumours. Poly(ADP-ribose) glycohydrolase (PARG) deficiency
Jean-Christophe Amé +9 more
core +1 more source
Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.Abstract Background Elevated brain iron deposition is recognized as a characteristic of normal aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), where it correlated with amyloid‐β plaques and neurofibrillary tangles. Our study aimed to investigate the relationship between longitudinal changes in hippocampal iron deposition ...
Jing Zhou +16 more
wiley +1 more source
ROS-Specific Huntingtin Interactions: Testing PARG activity in HD patient fibroblasts
, 2019 Comparison nuclear PAR levels in wild type and HD (TruHD) fibroblasts in response to a PARG inhibitor concentration gradient (as a measure of PARG activity).
Maiuri, Tamara +3 more
core +1 more source
PARG: A Macrodomain in Disguise
, 2011 Our understanding of poly-ADP-ribosylation as a posttranslational modification was limited by the lack of structural information on poly-ADP-ribose (PAR) hydrolysing enzymes.
Ladurner, Andreas G. +5 more
core +1 more source
Frontiers in Immunology, 2018 The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades.
Mercedes Peleteiro +12 more
doaj +1 more source
, 2017 HuR regulates all isoforms of PARG by binding a discrete minimal binding region (MBR) within its 3'UTR in both DDR- proficient MIA PaCa-2 and DDR- deficient Hs 766t cells.
Charles J. Yeo (14892446) +17 more
core +1 more source
Molecular Cancer, 2012 Background Cell death induced by poly(ADP-ribose) (PAR) and mediated by apoptosis-inducing factor (AIF) is well-characterized in models of ischemic tissue injury, but their roles in cancer cell death after chemotherapy are less understood.
Feng Xiaoxing +5 more
doaj +1 more source
Selective small molecule inhibition of poly(ADP-ribose) glycohydrolase (PARG
, 2015 : The poly(ADP-ribose) (PAR) post-transla-tional modification is essential for diverse cellular functions, including regulation of transcription, response to DNA damage, and mitosis. Cellular PAR is predominantly synthesized by the enzyme poly(ADP-ribose)
Claire E. Knezevic +9 more
core +1 more source