Results 71 to 80 of about 6,727 (169)

Polymeric Nanocapsules for Vaccine Delivery: Influence of the Polymeric Shell on the Interaction With the Immune System

Frontiers in Immunology, 2018
The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades.
Mercedes Peleteiro, Elena Presas, Elena Presas, Jose Vicente González-Aramundiz, Jose Vicente González-Aramundiz, Beatriz Sánchez-Correa, Beatriz Sánchez-Correa, Rosana Simón-Vázquez, Noemi Csaba, Noemi Csaba, María J. Alonso, María J. Alonso, África González-Fernández   +12 more
doaj   +1 more source

Silencing of Apoptosis-Inducing factor and poly(ADP-ribose) glycohydrolase reveals novel roles in breast cancer cell death after chemotherapy

Molecular Cancer, 2012
Background Cell death induced by poly(ADP-ribose) (PAR) and mediated by apoptosis-inducing factor (AIF) is well-characterized in models of ischemic tissue injury, but their roles in cancer cell death after chemotherapy are less understood.
Feng Xiaoxing, Zhou Yiran, Proctor Alicia M, Hopkins Mandi M, Liu Mengwei, Koh David W   +5 more
doaj   +1 more source

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

Nature Communications
DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular level to exert TMEJ remains poorly characterized. We find that Polθ interacts with
Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T. Pomerantz, Tomasz Skorski   +12 more
doaj   +1 more source

Efficacy and safety of pegzilarginase in arginase 1 deficiency (PEACE): a phase 3, randomized, double-blind, placebo-controlled, multi-centre trialResearch in context

EClinicalMedicine
Summary: Background: Arginase 1 Deficiency (ARG1-D) is a rare debilitating, progressive, inherited, metabolic disease characterized by marked increases in plasma arginine (pArg) and its metabolites, with increased morbidity, substantial reductions in ...
Rossana Sanchez Russo, Serena Gasperini, Gillian Bubb, Linda Neuman, Leslie S. Sloan, George A. Diaz, Gregory M. Enns   +6 more
doaj   +1 more source

Reversal of tyrosine-linked ADP-ribosylation by ARH3 and PARG

Journal of Biological Chemistry
ADP-ribosylation is an ancient posttranslational modification with exceptional versatility in terms of breadth of modification targets including at least seven different amino acid side chains, various moieties on nucleic acids, and a variety of small chemical compounds.
Johannes Gregor Matthias Rack, Jim Voorneveld, Edoardo José Longarini, Sven Wijngaarden, Kang Zhu, Alessandra Peters, Jia Jhing Sia, Evgeniia Prokhorova, Dragana Ahel, Ivan Matić, Dmitri V. Filippov, Ivan Ahel   +11 more
openaire   +4 more sources

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

Cell Death and Disease
Complex DNA damage (CDD), containing two or more DNA lesions within one or two DNA helical turns, is a signature of ionising radiation (IR) and contributes significantly to the therapeutic effect through cell killing.
Maria Rita Fabbrizi, Catherine M. Nickson, Jonathan R. Hughes, Emily A. Robinson, Karthik Vaidya, Carlos P. Rubbi, Andrzej Kacperek, Helen E. Bryant, Thomas Helleday, Jason L. Parsons   +9 more
doaj   +1 more source

Kinetics of Human Serum Albumin Adsorption on Polycation Functionalized Silica

Biomolecules
The adsorption kinetics of human serum albumin (HSA) on bare and poly-L-arginine (PARG)-modified silica substrates were investigated using reflectometry and atomic force microscopy (AFM).
Małgorzata Nattich-Rak, Dominik Kosior, Maria Morga, Zbigniew Adamczyk   +3 more
doaj   +1 more source

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer

Cell Death Discovery
Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC). Altered DNA repair and metabolic signaling is implicated in mediating therapeutic resistance.
Ganesh Acharya, Chinnadurai Mani, Naresh Sah, Karunakar Saamarthy, Robert Young, Mark B. Reedy, Robert W. Sobol, Komaraiah Palle   +7 more
doaj   +1 more source

TEMPERATURE SUMS AND CLIMATIC VARIATIONS IN THE PARG REGION

Hrvatski meteorološki časopis, 2005
Time series of temperature sums for the different temperature thresholds from the Parg station in the Croatia mountain area during the vegetation period from 1951 to 2004 have been analysed. The temperature differences between mean temperatures and temperatures thresholds are called the temperature sums or degree days and they are frequently applied in
Vučetić, Višnja, Vučetić, Marko
openaire   +4 more sources

CHD1L maintains genome integrity by facilitating okazaki fragment maturation. [PDF]

Nucleic Acids Res
Nie L, Fu J, Huang M, Zhang H, Ma T, Yang C, Li S, Wang C, Chen J.   +8 more
europepmc   +1 more source