Results 91 to 100 of about 7,374 (163)

CHK1 inhibitor induced PARylation by targeting PARG causes excessive replication and metabolic stress and overcomes chemoresistance in ovarian cancer

Cell Death Discovery
Chemoresistance contributes to the majority of deaths in women with ovarian cancer (OC). Altered DNA repair and metabolic signaling is implicated in mediating therapeutic resistance.
Ganesh Acharya, Chinnadurai Mani, Naresh Sah, Karunakar Saamarthy, Robert Young, Mark B. Reedy, Robert W. Sobol, Komaraiah Palle   +7 more
doaj   +1 more source

2,4-DIOXO-QUINAZOLINE-6-SULFONAMIDE DERIVATIVES AS INHIBITORS OF PARG

, 2016
The present invention relates to compounds of formula I that function as inhibitors of PARG (Poly ADP-ribose glycohydrolase) enzyme activity wherein R1a, R1b, R1c, R1d, R1e, W, X1, X2, X3, X4, X5, X6, X7, c are each as defined herein.
Jordan,, Allan, Waszkowycz,, Bohdan, Hutton,, Colin, Smith, Kate, Hitchin, James, Hamilton, Niall, Waddell,, Ian, Mcgonagle, Alison   +7 more
core   +1 more source

La modulation de l'expression du gène PARG par l'interférence à l'ARN sensibilise les cellules de gliomes humains aux rayons ionisant

, 2011
La poly(ADP-ribosyl)ation est une modification post-traductionnelle effectuée par les poly(ADP-ribose) polymerases (PARP), des enzymes à prédominance nucléaire qui catalysent la formation de polymères d'ADP-ribose sur des protéines acceptrices en ...
Ferlotte-Picard, Guillaume
core  

Inhibition of PARG activity affects lysosomal function and hampers T. cruzi infection in Vero cells

, 2020
Chagas disease is a potentially life-threatening protozoan infection with little therapeuticalternatives. Since Trypanosoma cruzi triggers different host cell signaling pathways, targetingthem can be therapeutically valuable.
Chiatellino, Maria Clara, Svagzdys, Ailin, Fernandez Villamil, Silvia Hebe, Vilchez Larrea, Salomé Catalina   +3 more
core  

INVESTIGATION OF POLY(ADP-RIBOSE) GLYCOHYDROLASE (PARG) IN CANCER DISCOVERY OF NOVEL TARGETS TO IMPROVE CHEMOTHERAPY

, 2013
Poly(ADP-ribose) glycohydrolase (PARG) is the primary enzyme that catalyzes the hydrolysis of poly(ADP-ribose) (PAR), which is synthesized by poly(ADP-ribose) polymerases (PARPs) to modify cellular proteins.
Feng, Xiaoxing
core  

Parg deficiency confers radio-sensitization through enhanced cell death in mouse ES cells exposed to various forms of ionizing radiation

, 2013
Poly(ADP-ribose) glycohydrolase (Parg) is the main enzyme involved in poly(ADP-ribose) degradation. Here, the effects of Parg deficiency on sensitivity to low and high linear-energy-transfer (LET) radiation were investigated in mouse embryonic stem (ES ...
Fujimori, Hiroaki, 益谷 美都子, 白井 秀徳, 平井 崇久, Shirai, Hidenori, Masutani, Mitsuko, 464018, 464017, 笹井 啓資, 464019, 464014, 岡安 隆一, 464025, 464024, 464016, et.al, 464015, 464021, Hirai, Takahisa, 464020, 464023, 464022, Okayasu, Ryuichi, Sasai, Keisuke   +23 more
core  

Poly (ADP-ribose) glycohydrolase (PARG) is a new therapeutic target for breast cancer

, 2013
Breast cancer is a heterogeneous disease, but is invariably associated with genome wide deregulation of transcription. The silencing of tumor suppressor genes (TSGs) in particular is thought to be an early, initiating event in many cancers.
Lovato, Amanda
core  

Intrinsic PARG inhibitor sensitivity is mimicked by TIMELESS haploinsufficiency and rescued by nucleoside supplementation

A subset of cancer cells are intrinsically sensitive to inhibitors targeting PARG, the poly(ADP-ribose) glycohydrolase that degrades PAR chains. Sensitivity is accompanied by persistent DNA replication stress, and can be induced by inhibition of TIMELESS,
Pillay, Nisha, Lin, Wei-Hsiang, McGrail, Joanne C., Anagho, Holda A, Brady, Rosie M., Bronder, Daniel, Nelson, Louisa, Taylor, Stephen, Mcgrail, Joanne, Littler, Samantha, Anagho, Holda A., Tighe, Anthony, Morgan, Robert D., Unwin, Richard; id_orcid, Morgan, Robert; id_orcid, Brady, Rosie, Dey, Malini, Lin, Wei Hsiang, Barnes, Bethany, Unwin, Richard D., Taylor, Stephen S., Barnes, Bethany M., Coulson-Gilmer, Camilla, Nielsen, Michael L, Macmorland, William, Nielsen, Michael L.   +25 more
core   +1 more source

Genes Encoding Several Poly (ADP-Ribose) Glycohydrolase (PARG) Enzymes, the Proteins and Fragments Thereof, and Antibodies Immunoreactive Therewith

, 2009
The isolation and characterization of cDNAs encoding poly(ADP-ribose) glycohydrolase (PARG) enzymes and the amino acid sequences of PARGs from several species are described.
Amé, Jean-Christoph, Lin, Winston, Jacobson, Elaine L., Jacobson, Myron   +3 more
core  

Parg deficiency sensitizes to radiation of low-high LET with enhanced apoptosis induction in mouse ES cells

, 2011
Poly(ADP-ribose) glycohydrolase (Parg) is the main enzyme for poly(ADP-ribose) degradation. The impact of Parg and poly(ADP-ribose) polymerase-1 (Parp-1) deficiency for sensitization of low to high linear-energy-transfer (LET) radiation was studied in ...
益谷 美都子, 白井 秀徳, 平井 崇久, Shirai, Hidenori, Masutani, Mitsuko, 笹井 啓資, 岡安 隆一, 634377, Hirai, Takahisa, 634378, 634379, 634384, 634385, 634386, Okayasu, Ryuichi, 634380, 634381, 634382, 634383, Sasai, Keisuke   +19 more
core