Results 91 to 100 of about 12,704 (204)
Pharmaceutics, 2020 Microencapsulation and targeted delivery of cytotoxic and antibacterial agents of photodynamic therapy (PDT) improve the treatment outcomes for infectious diseases and cancer.
Alexey V. Ermakov +9 more
doaj +1 more source
Poincar\'e series of modules over compressed Gorenstein local rings
, 2014 Given positive integers e and s we consider Gorenstein Artinian local rings R of embedding dimension e whose maximal ideal $\mathfrak{m}$ satisfies $\mathfrak{m}^s\ne 0=\mathfrak{m}^{s+1}$.
Rossi, Maria Evelina, Şega, Liana M
core +1 more source
PARP1 gene expression is downregulated by knockdown of PARG gene
Oncology Reports, 2013 Poly(ADP-ribosyl)ation is a modification of nuclear proteins that regulates DNA replication, repair and transcription. In order to investigate the biological effects of degradation of poly(ADP-ribose), knockdown of the poly(ADP-ribose) glycohydrolase (PARG) gene was performed by introducing a short interfering RNA (siRNA)-pool into HeLa S3 cells ...
UCHIUMI, FUMIAKI +4 more
openaire +3 more sources
Compact convex sets of the plane and probability theory
, 2014 The Gauss-Minkowski correspondence in $\mathbb{R}^2$ states the existence of a homeomorphism between the probability measures $\mu$ on $[0,2\pi]$ such that $\int_0^{2\pi} e^{ix}d\mu(x)=0$ and the compact convex sets (CCS) of the plane with perimeter~1 ...
Marckert, Jean-François, Renault, David
core +2 more sources
Idiopathic Pulmonary Fibrosis: Cellular Heterogeneity, Mechanisms, and Therapeutic Implications
MedComm, Volume 6, Issue 12, December 2025.Single‐cell sequencing has elucidated cell‐type‐specific transcriptional alterations, activated signaling pathways, metabolic reprogramming, immune infiltration, and chromatin‐associated genetic mechanisms in IPF, uncovering novel therapeutic targets.
Lin Zuo +4 more
wiley +1 more source
PARG regulates the proteasomal degradation of TARG1
Cell ReportsSummary: ADP-ribosylation (ADPr) is a reversible modification of macromolecules critical for the regulation of genome stability, stress responses, and proteostasis.
Joséphine Groslambert +15 more
doaj +1 more source
Study of N-Phosphorylation on Peptide and Protein-- Preparation of Phosphoramidate and Application of anti-Phosphoarginine Antibody [PDF]
, 2016 蛋白质有诸多翻译后修饰（post-translationalmodifications，PTMs），包括甲基化、泛素化、乙酰化和磷酸化等等。其中，磷酸化修饰被认为是调控蛋白质功能的重要“开关”，是细胞内信号转导的关键机制，与人类多种疾病的发生密切相关。目前，天然蛋白质中共发现有9种氨基酸可以被磷酸化，其中包括以P-O键连接的磷酸酯类修饰，如磷酸化丝氨酸、苏氨酸和酪氨酸；以P-N键连接的磷酰胺类修饰，如磷酸化组氨酸、精氨酸和赖氨酸；酰基酸化是通过天冬氨酸或谷氨酸的磷酸化形成的，而S ...
孙影
core
PARP and PARG Inhibitors—New Therapeutic Targets in Cancer Treatment
Pathology & Oncology Research, 2010 Today, the number of cancer patients throughout the world is increasing alarmingly and as per the World Health Organisation (WHO) data and statistics the prediction for the year 2020 will be 15 million new cases as compared to only 10 million cases in year 2000 leaving us dumbfounded.
Nilufer Jasmine Selimah, Fauzee +2 more
openaire +2 more sources
Frontiers in Immunology, 2018 The use of biomaterials and nanosystems in antigen delivery has played a major role in the development of novel vaccine formulations in the last few decades.
Mercedes Peleteiro +12 more
doaj +1 more source
Molecular Cancer, 2012 Background Cell death induced by poly(ADP-ribose) (PAR) and mediated by apoptosis-inducing factor (AIF) is well-characterized in models of ischemic tissue injury, but their roles in cancer cell death after chemotherapy are less understood.
Feng Xiaoxing +5 more
doaj +1 more source