Results 101 to 110 of about 12,704 (204)

Intranasal administration of a PARG inhibitor profoundly decreases ischemic brain injury

Frontiers in Bioscience, 2007
Cumulative evidence has indicated a critical role of poly(ADP-ribose) polymerase-1 activation in ischemic brain damage. Poly(ADP-ribose) glycohydrolase (PARG) is a key enzyme in poly(ADP-ribose) catabolism. Our previous studies showed that PARG inhibitors, gallotannin (GT) and nobotanin B, can profoundly decrease oxidative cell death in vitro. Here, we
Wei, Guangwei, Wang, Dongmin, Lu, Huafei, Parmentier, Sophie, Wang, Qing, Panter, S. Scott, Frey II, William H., Ying, Weihai   +7 more
openaire   +4 more sources

PARG is essential for Polθ-mediated DNA end-joining by removing repressive poly-ADP-ribose marks

Nature Communications
DNA polymerase theta (Polθ)-mediated end-joining (TMEJ) repairs DNA double-strand breaks and confers resistance to genotoxic agents. How Polθ is regulated at the molecular level to exert TMEJ remains poorly characterized. We find that Polθ interacts with
Umeshkumar Vekariya, Leonid Minakhin, Gurushankar Chandramouly, Mrityunjay Tyagi, Tatiana Kent, Katherine Sullivan-Reed, Jessica Atkins, Douglas Ralph, Margaret Nieborowska-Skorska, Anna-Mariya Kukuyan, Hsin-Yao Tang, Richard T. Pomerantz, Tomasz Skorski   +12 more
doaj   +1 more source

METEOROLOGICAL FEATURES OF EXTREME PRECIPITATION IN THE NORTHERN ADRIATIC [PDF]

, 2006
An investigation of extreme precipitation cases in the northern Adriatic area is discussed in this paper. The criterion chosen for an extreme event recognition is a measured daily precipitation amount exceeding 100 mm day-1.
Branka Ivančan-Picek, Tomislav Kozarić
core   +2 more sources

A sejtmag és a mitokondriumok közötti kommunikáció poli-ADP-ribozilációs szabályozása oxidatív stresszben = Regulation of nuclear-mitochondrial crosstalk by poly-ADP-ribosylation in oxidative stress [PDF]

, 2010
Kutatásainkban egy poli-ADP-ribozilációnak (PARiláció) nevezett fehérjemódusítást tanulmányoztunk és vizsgáltuk, milyen szerepet játszik a sejthalál és a gyulladás folyamatainak szabályozásában. Olyan sejtvonalakat állítottunk elő, melyekben inaktiváltuk
Bakondi, Edina, Virág, László
core  

A finite element boundary integral formulation for radiation and scattering by cavity antennas using tetrahedral elements [PDF]

A hybrid finite element boundary integral formulation is developed using tetrahedral and/or triangular elements for discretizing the cavity and/or aperture of microstrip antenna arrays.
Chatterjee, A., Gong, J., Jin, J. M., Volakis, J. L.   +3 more
core   +1 more source

Efficacy and safety of pegzilarginase in arginase 1 deficiency (PEACE): a phase 3, randomized, double-blind, placebo-controlled, multi-centre trialResearch in context

EClinicalMedicine
Summary: Background: Arginase 1 Deficiency (ARG1-D) is a rare debilitating, progressive, inherited, metabolic disease characterized by marked increases in plasma arginine (pArg) and its metabolites, with increased morbidity, substantial reductions in ...
Rossana Sanchez Russo, Serena Gasperini, Gillian Bubb, Linda Neuman, Leslie S. Sloan, George A. Diaz, Gregory M. Enns   +6 more
doaj   +1 more source

Poly(ADP-Ribosyl)ation affects stabilization of CHE-1 protein in response to DNA damage [PDF]

, 2011
Post-translation modifications play a crucial role in coordinating the cellular response to DNA damage. Double strand DNA breaks (DSBs) trigger the activation of ATM and Chk2 kinases, which represent the primary transducers in the signalling cascade ...
BACALINI, MARIA GIULIA
core  

Reversal of tyrosine-linked ADP-ribosylation by ARH3 and PARG

Journal of Biological Chemistry
ADP-ribosylation is an ancient posttranslational modification with exceptional versatility in terms of breadth of modification targets including at least seven different amino acid side chains, various moieties on nucleic acids, and a variety of small chemical compounds.
Johannes Gregor Matthias Rack, Jim Voorneveld, Edoardo José Longarini, Sven Wijngaarden, Kang Zhu, Alessandra Peters, Jia Jhing Sia, Evgeniia Prokhorova, Dragana Ahel, Ivan Matić, Dmitri V. Filippov, Ivan Ahel   +11 more
openaire   +4 more sources

PARG inhibition in ATM-deficient prostate cancer: from mechanistic discovery to therapeutic potential

Journal of Translational Medicine
Background ATM deficiency is frequently observed in castration-resistant prostate cancer (CRPC). However, effective therapeutic vulnerabilities associated with this genetic alteration remain poorly defined.
Xuan Zhou, Chunyu Guo, Zhiguo Fan, Yihaoyun Lou, Zhiying Yue, Weidong Xu, Zhixiang Xin, Shancheng Ren   +7 more
doaj   +1 more source

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

Cell Death and Disease
Complex DNA damage (CDD), containing two or more DNA lesions within one or two DNA helical turns, is a signature of ionising radiation (IR) and contributes significantly to the therapeutic effect through cell killing.
Maria Rita Fabbrizi, Catherine M. Nickson, Jonathan R. Hughes, Emily A. Robinson, Karthik Vaidya, Carlos P. Rubbi, Andrzej Kacperek, Helen E. Bryant, Thomas Helleday, Jason L. Parsons   +9 more
doaj   +1 more source