Results 121 to 130 of about 6,989 (168)
Are you having a LaPh? Diverse roles of Labile Phosphorylation in mammalian cells. [PDF]
Biochem Soc TransClarke CJ, Eyers CE.
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PARG Inhibitors and Functional PARG Inhibition Models
Current Protein & Peptide Science, 2016Poly(ADP-ribose) polymerases (PARPs) family proteins catalyze poly(ADP-ribosylation) (PARylation) by conjugating ADP-ribose residues repeatedly on amino acid residues using nicotinamide adenine dinucleotide as a substrate. The inhibitors of PARP widely block DNA repair processes and are currently examined in clinical trials of cancer therapy.
Yuka, Sasaki +6 more
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Purification of Recombinant Human PARG and Activity Assays
2022The purification of poly(ADP-ribose) glycohydrolase (PARG) from overexpressing bacteria Escherichia coli is described here as a fast and reproducible one chromatographic step protocol. After cell lysis, GST-PARG-fusion proteins from the crude extract are affinity purified by a glutathione 4B sepharose chromatographic step.
Amé, Jean-Christophe +1 more
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Plant PARPs, PARGs and PARP-like Proteins
Current Protein & Peptide Science, 2016Poly(ADP-ribos)ylation, originally described as a mechanism of DNA break repair, is now considered as part of a complex regulatory system involved in dynamic reorganization of chromatin structure, transcriptional control of gene expression and regulation of metabolism. In plants poly(ADP-ribos)ylation has received surprisingly little attention.
Julia P, Vainonen +3 more
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PARP and PARG as novel therapeutic targets
Drugs of the Future, 2002Poly(ADP-ribose) is synthesized by poly(ADP-ribose) polymerase (PARP) from β-nicotinamide adenine dinucleotide (NAD + ). It is mainly degraded by poly(ADP-ribose) glycohydrolase (PARG). The expanding family of PARP currently consists of PARP 1 - 3 , vPARP, Tankyrase 1 - 2 , 2 , and more members are being characterized.
null Zhang, J., null Li, J.-H.
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PARG Protein Regulation Roles in Drosophila Longevity Control
International Journal of Molecular SciencesAging, marked by a gradual decline in physiological function and heightened vulnerability to age-related diseases, remains a complex biological process with multifaceted regulatory mechanisms. Our study elucidates the critical role of poly(ADP–ribose) glycohydrolase (PARG), responsible for catabolizing poly(ADP–ribose) (pADPr) in the aging process by ...
Alexei Tulin, Guillaume Bordet
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PARG inhibition induces nuclear aggregation of PARylated PARP1
StructurePoly (ADP-ribose) glycohydrolase (PARG) inhibitors are currently under clinical development for the treatment of DNA repair-deficient cancers; however, their precise mechanism of action is still unclear. Here, we report that PARG inhibition leads to excessive PARylated poly (ADP-ribose) polymerase 1 (PARP1) reducing the ability of PARP1 to properly ...
Ranjit S Bindra +2 more
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PARG inhibition limits HCC progression and potentiates the efficacy of immune checkpoint therapy
Journal of Hepatology, 2022Jia Fan, Bo Hu, Lei Guo
exaly