Results 131 to 140 of about 6,740 (170)

Deltex and RING-UIM E3 ligases cooperate to create a ubiquitin-ADP-ribose hybrid mark on tankyrase, promoting its stabilization. [PDF]

Sci Adv
Perrard J, Gao K, Ring K, Smith S.
europepmc   +1 more source

Mechanistic insights into the monotherapy and combination potential of FEN1 inhibition in cancer therapy. [PDF]

Nucleic Acids Res
Rajendra E, Lademann CA, Mason B, Mardin BR, Armstrong L, Peripolli S, Kreis J, Konstantinou T, Pehl U, Bomke J, Scharrelmann S, Perera D, Leuthner B, Pinto MF, Davis OA, Galbiati A, Toste Rêgo A, McWhirter CL, Elinati E, Sala-Hojman A, Lefranc J, Mann SE, Heald RA, Zenke FT, Smith GCM, Robinson HMR, Burgdorf LT.   +26 more
europepmc   +1 more source

Some of the next articles are maybe not open access.

Related searches:

PARG Inhibitors and Functional PARG Inhibition Models

Current Protein & Peptide Science, 2016
Poly(ADP-ribose) polymerases (PARPs) family proteins catalyze poly(ADP-ribosylation) (PARylation) by conjugating ADP-ribose residues repeatedly on amino acid residues using nicotinamide adenine dinucleotide as a substrate. The inhibitors of PARP widely block DNA repair processes and are currently examined in clinical trials of cancer therapy.
Yuka, Sasaki, Miyuki, Hozumi, Hiroaki, Fujimori, Yasufumi, Murakami, Fumiaki, Koizumi, Kengo, Inoue, Mitsuko, Masutani   +6 more
openaire   +2 more sources

Purification of Recombinant Human PARG and Activity Assays

2022
The purification of poly(ADP-ribose) glycohydrolase (PARG) from overexpressing bacteria Escherichia coli is described here as a fast and reproducible one chromatographic step protocol. After cell lysis, GST-PARG-fusion proteins from the crude extract are affinity purified by a glutathione 4B sepharose chromatographic step.
Amé, Jean-Christophe, Dantzer, Françoise   +1 more
openaire   +3 more sources

Plant PARPs, PARGs and PARP-like Proteins

Current Protein & Peptide Science, 2016
Poly(ADP-ribos)ylation, originally described as a mechanism of DNA break repair, is now considered as part of a complex regulatory system involved in dynamic reorganization of chromatin structure, transcriptional control of gene expression and regulation of metabolism. In plants poly(ADP-ribos)ylation has received surprisingly little attention.
Julia P, Vainonen, Alexey, Shapiguzov, Aleksia, Vaattovaara, Jaakko, Kangasjärvi   +3 more
openaire   +2 more sources

PARP and PARG as novel therapeutic targets

Drugs of the Future, 2002
Poly(ADP-ribose) is synthesized by poly(ADP-ribose) polymerase (PARP) from β-nicotinamide adenine dinucleotide (NAD + ). It is mainly degraded by poly(ADP-ribose) glycohydrolase (PARG). The expanding family of PARP currently consists of PARP 1 - 3 , vPARP, Tankyrase 1 - 2 , 2 , and more members are being characterized.
null Zhang, J., null Li, J.-H.
openaire   +1 more source

Targeting PARG in HCC

Nature Reviews Gastroenterology & Hepatology, 2022
openaire   +2 more sources

INHIBITORS OF PARG

2023
CHANG PAUL, WIDDOWSON KATHERINE, AMES LISA J   +2 more
openaire   +5 more sources