PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation [PDF]
EMBO JournalPARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Rebecca Smith +2 more
exaly +3 more sources
ADP-ribosylation: An emerging regulator of the epigenome. [PDF]
Mol OncolADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Camacho CV, Liu C, Kraus WL.
europepmc +2 more sources
Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation [PDF]
The EMBO JournalADP-ribosylation is an important protein post-translational modification catalysed by a family of PARP enzymes in humans and is involved in DNA damage and immunity among other processes.
Andrii Gorelik +6 more
doaj +2 more sources
ADP-Ribosylation of Cytidine: A Novel Nucleic Acid Modification Reversed by NADAR Hydrolases [PDF]
ToxinsADP-ribosylation of nucleic acids is a modification found in both eukaryotes and bacteria, where it contributes to genome maintenance but can also serve as a toxic mechanism used by bacterial toxins to disrupt essential cellular processes.
Petra Mikolčević +6 more
doaj +2 more sources
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection [PDF]
Nature CommunicationsADP-ribosylation is a highly dynamic and fully reversible post-translational modification performed by PARP enzymes that modulates protein function, abundance, localization, and turnover. Here we show that PARPs mount an antiviral response to influenza A
Zhenyu Zhang +17 more
doaj +2 more sources
NAD<sup>+</sup> Metabolism Licenses Zygotic Genome Activation via PARP7-Mediated ADP-Ribosylation of UHRF1 in Mouse Early Embryos. [PDF]
Adv Sci (Weinh)This study uncovers a metabolic‐epigenetic axis licensing zygotic genome activation (ZGA) in mouse embryos. A developmental decline in NAD+ levels activates PARP7, which mono‐ADP‐ribosylates and stabilizes UHRF1. This modification promotes the establishment of permissive histone acetylation marks, thereby facilitating timely ZGA.
Cao G +13 more
europepmc +2 more sources
Control of replication and gene expression by ADP-ribosylation of DNA in Mycobacterium tuberculosis [PDF]
The EMBO JournalMycobacterium tuberculosis maintains long-term infections characterised by the need to regulate growth and adapt to contrasting in vivo environments. Here we show that M.
Rachel E Butler +9 more
doaj +2 more sources
ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription
Cell ReportsSummary: Single-strand breaks (SSBs) are prevalent DNA lesions implicated in genome instability. The nuclear mitotic apparatus protein (NuMA) has been reported to promote SSB repair (SSBR) and regulate transcription following oxidative stress.
Arwa A. Abugable +4 more
doaj +2 more sources
Interplay of Histone Marks with Serine ADP-Ribosylation
Cell Reports, 2018 Summary: Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1).
Juan José Bonfiglio +2 more
exaly +3 more sources
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation
EMBO JournalProtein ADP-ribosylation plays important but ill-defined roles in antiviral signalling cascades such as the interferon response. Several viruses of clinical interest, including coronaviruses, express hydrolases that reverse ADP-ribosylation catalysed by ...
Nicolas Carlos Hoch +2 more
exaly +2 more sources