Results 1 to 10 of about 39,153 (185)

Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation [PDF]

The EMBO Journal
ADP-ribosylation is an important protein post-translational modification catalysed by a family of PARP enzymes in humans and is involved in DNA damage and immunity among other processes.
Andrii Gorelik, Nina Đukić, Rebecca Smith, Chatrin Chatrin, Osamu Suyari, Jason Matthews, Ivan Ahel   +6 more
doaj   +2 more sources

Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection [PDF]

Nature Communications
ADP-ribosylation is a highly dynamic and fully reversible post-translational modification performed by PARP enzymes that modulates protein function, abundance, localization, and turnover. Here we show that PARPs mount an antiviral response to influenza A
Zhenyu Zhang, Isabel Uribe, Kaitlin A. Davis, Robert L. McPherson, Gloria P. Larson, Mohsen Badiee, Vy Tran, Mitchell P. Ledwith, Elizabeth M. Feltman, Shuǐqìng Yú, Yíngyún Caì, Che-Yuan Chang, Xingyi Yang, Zhuo Ma, Paul Chang, Jens H. Kuhn, Anthony K. L. Leung, Andrew Mehle   +17 more
doaj   +2 more sources

ADP-Ribosylation of Cytidine: A Novel Nucleic Acid Modification Reversed by NADAR Hydrolases [PDF]

Toxins
ADP-ribosylation of nucleic acids is a modification found in both eukaryotes and bacteria, where it contributes to genome maintenance but can also serve as a toxic mechanism used by bacterial toxins to disrupt essential cellular processes.
Petra Mikolčević, Andrea Hloušek-Kasun, Marion Schuller, Yang Lu, Elena Pirović, Ivan Ahel, Andreja Mikoč   +6 more
doaj   +2 more sources

Control of replication and gene expression by ADP-ribosylation of DNA in Mycobacterium tuberculosis [PDF]

The EMBO Journal
Mycobacterium tuberculosis maintains long-term infections characterised by the need to regulate growth and adapt to contrasting in vivo environments. Here we show that M.
Rachel E Butler, Marion Schuller, Ritu Jaiswal, Jayanta Mukhopadhyay, Jim Barber, Suzie Hingley-Wilson, Emily Wasson, Alexassander Couto Alves, Ivan Ahel, Graham R Stewart   +9 more
doaj   +2 more sources

ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription

Cell Reports
Summary: Single-strand breaks (SSBs) are prevalent DNA lesions implicated in genome instability. The nuclear mitotic apparatus protein (NuMA) has been reported to promote SSB repair (SSBR) and regulate transcription following oxidative stress.
Arwa A. Abugable, Chunyan Liao, Sarah Antar, Matthew Dowson, Sherif F. El-Khamisy   +4 more
doaj   +2 more sources

Interplay of Histone Marks with Serine ADP-Ribosylation

Cell Reports, 2018
Summary: Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1).
Juan JOSÉ Bonfiglio, Evgeniia Prokhorova, Ivan Ahel   +2 more
exaly   +3 more sources

Specificity of DNA ADP-Ribosylation Reversal by NADARs [PDF]

Toxins
Recent discoveries establish DNA and RNA as bona fide substrates for ADP-ribosylation. NADAR (“NAD- and ADP-ribose”-associated) enzymes reverse guanine ADP-ribosylation and serve as antitoxins in the DarT-NADAR operon.
Bara Cihlova, Yang Lu, Andreja Mikoč, Marion Schuller, Ivan Ahel   +4 more
doaj   +2 more sources

PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation

EMBO Journal
Protein ADP-ribosylation plays important but ill-defined roles in antiviral signalling cascades such as the interferon response. Several viruses of clinical interest, including coronaviruses, express hydrolases that reverse ADP-ribosylation catalysed by ...
Nicolas CARLOS Hoch, Lilian Cristina Russo, Victoria Chaves Ribeiro   +2 more
exaly   +2 more sources

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation

EMBO Journal
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Rebecca Smith, Nicolas Bigot, Sanyal Sumana   +2 more
exaly   +2 more sources

General ADP-Ribosylation Mechanism Based on the Structure of ADP-Ribosyltransferase–Substrate Complexes [PDF]

Toxins
ADP-ribosylation is a ubiquitous modification of proteins and other targets, such as nucleic acids, that regulates various cellular functions in all kingdoms of life.
Hideaki Tsuge, Noriyuki Habuka, Toru Yoshida   +2 more
doaj   +2 more sources