Results 1 to 10 of about 214,575 (242)
PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
EMBO JournalPARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Nina Đukić, Osamu Suyari, Kang Zhu
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Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling [PDF]
Nature Communications, 2023 In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial importance to mark sites of DNA damage as well as recruit and regulate repairs factors.
Pietro Fontana +9 more
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Mitochondrial NAD+ Controls Nuclear ARTD1-Induced ADP-Ribosylation [PDF]
Molecular Cell, 2021 Summary In addition to its role as an electron transporter, mitochondrial nicotinamide adenine dinucleotide (NAD+) is an important co-factor for enzymatic reactions, including ADP-ribosylation.
Corentin Gondrand +2 more
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Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight [PDF]
Cells, 2021 Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids.
Ann-Katrin Hopp, Michael O. Hottiger
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Functional roles of ADP-ribosylation writers, readers and erasers
Frontiers in Cell and Developmental Biology, 2022 ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers.
Ping Li +4 more
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PARPs and ADP-ribosylation: Deciphering the complexity with molecular tools
Molecular Cell, 2023 SUMMARY PARPs catalyze ADP-ribosylation—a post-translational modification that plays crucial roles in biological processes, including DNA repair, transcription, immune regulation, and condensate formation. ADP-ribosylation can be added to a wide range of
Morgan Dasovich, Anthony K L Leung
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Nature CommunicationsEster-linked post-translational modifications, including serine and threonine ubiquitination, have gained recognition as important cellular signals. However, their detection remains a significant challenge due to the chemical lability of the ester bond ...
Edoardo José Longarini, Ivan Matić
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Molecular Cell, 2023 SUMMARY PARP1, an established anti-cancer target that regulates many cellular pathways, including DNA repair signaling, has been intensely studied for decades as a poly(ADP-ribosyl)transferase. Although recent studies have revealed the prevalence of mono-
Helen Dauben +2 more
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Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation [PDF]
The EMBO JournalADP-ribosylation is an important protein post-translational modification catalysed by a family of PARP enzymes in humans and is involved in DNA damage and immunity among other processes.
Andrii Gorelik +6 more
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Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection [PDF]
Nature CommunicationsADP-ribosylation is a highly dynamic and fully reversible post-translational modification performed by PARP enzymes that modulates protein function, abundance, localization, and turnover. Here we show that PARPs mount an antiviral response to influenza A
Zhenyu Zhang +17 more
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