Ubiquitin pathway blockade reveals endogenous ADP-ribosylation marking PARP7 and AHR for degradation [PDF]
The EMBO JournalADP-ribosylation is an important protein post-translational modification catalysed by a family of PARP enzymes in humans and is involved in DNA damage and immunity among other processes.
Andrii Gorelik +6 more
doaj +2 more sources
Global remodeling of ADP-ribosylation by PARP1 suppresses influenza A virus infection [PDF]
Nature CommunicationsADP-ribosylation is a highly dynamic and fully reversible post-translational modification performed by PARP enzymes that modulates protein function, abundance, localization, and turnover. Here we show that PARPs mount an antiviral response to influenza A
Zhenyu Zhang +17 more
doaj +2 more sources
ADP-Ribosylation of Cytidine: A Novel Nucleic Acid Modification Reversed by NADAR Hydrolases [PDF]
ToxinsADP-ribosylation of nucleic acids is a modification found in both eukaryotes and bacteria, where it contributes to genome maintenance but can also serve as a toxic mechanism used by bacterial toxins to disrupt essential cellular processes.
Petra Mikolčević +6 more
doaj +2 more sources
Control of replication and gene expression by ADP-ribosylation of DNA in Mycobacterium tuberculosis [PDF]
The EMBO JournalMycobacterium tuberculosis maintains long-term infections characterised by the need to regulate growth and adapt to contrasting in vivo environments. Here we show that M.
Rachel E Butler +9 more
doaj +2 more sources
ADP-ribosylation of NuMA promotes DNA single-strand break repair and transcription
Cell ReportsSummary: Single-strand breaks (SSBs) are prevalent DNA lesions implicated in genome instability. The nuclear mitotic apparatus protein (NuMA) has been reported to promote SSB repair (SSBR) and regulate transcription following oxidative stress.
Arwa A. Abugable +4 more
doaj +2 more sources
Interplay of Histone Marks with Serine ADP-Ribosylation
Cell Reports, 2018 Summary: Serine ADP-ribosylation (Ser-ADPr) is a recently discovered protein modification that is catalyzed by PARP1 and PARP2 when in complex with the eponymous histone PARylation factor 1 (HPF1).
Juan José Bonfiglio +2 more
exaly +3 more sources
Specificity of DNA ADP-Ribosylation Reversal by NADARs [PDF]
ToxinsRecent discoveries establish DNA and RNA as bona fide substrates for ADP-ribosylation. NADAR (“NAD- and ADP-ribose”-associated) enzymes reverse guanine ADP-ribosylation and serve as antitoxins in the DarT-NADAR operon.
Bara Cihlova +4 more
doaj +2 more sources
PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation
EMBO JournalPARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Nina Đukić, Osamu Suyari, Kang Zhu
exaly +2 more sources
General ADP-Ribosylation Mechanism Based on the Structure of ADP-Ribosyltransferase–Substrate Complexes [PDF]
ToxinsADP-ribosylation is a ubiquitous modification of proteins and other targets, such as nucleic acids, that regulates various cellular functions in all kingdoms of life.
Hideaki Tsuge +2 more
doaj +2 more sources
Processes underlying the nutritional programming of embryonic development by iron deficiency in the rat [PDF]
, 2012 Peer reviewedPublisher ...
Gambling, Lorraine +5 more
core +16 more sources