Results 1 to 10 of about 81,859 (163)
Poly(ADP-ribose): PARadigms and PARadoxes [PDF]
Molecular Aspects of Medicine, 2013 Poly(ADP-ribosyl)ation (PARylation) is a posttranslational protein modification (PTM) catalyzed by members of the poly(ADP-ribose) polymerase (PARP) enzyme family. PARPs use NAD(+) as substrate and upon cleaving off nicotinamide they transfer the ADP-ribosyl moiety covalently to suitable acceptor proteins and elongate the chain by adding further ADP ...
László Virág, Alexander Bürkle
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Identification of RNF114 as ADPr-Ub reader through non-hydrolysable ubiquitinated ADP-ribose [PDF]
Nature CommunicationsCrosstalk between the post-translational modification processes of ubiquitination and ADP-ribosylation occurs in DNA-damage- and immune-responses, in addition the physical linkage of ADP-ribose and ubiquitin is found during bacterial infection.
Max S. Kloet +14 more
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Pathogens, 2023 Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar +3 more
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Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.
PLoS ONE, 2021 ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson +2 more
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Determination of ADP‐ribose and Poly(ADP‐ribose) by a New Radioimmunoassay [PDF]
European Journal of Biochemistry, 1978 A specific and sensitive radioimmunoassay for ADP‐ribose has been developed on the basis of the selective conversion of ADP‐ribose to 5′‐AMP by alkaline treatment. Antibodies highly specific against 5′‐AMP allowed quantification of ADP‐ribose converted to 5′‐AMP in the range of 1–40 pmol, and in the presence of large quantities of nucleic acids or 3 ...
R, Bredehorst, A M, Ferro, H, Hilz
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ARH Family of ADP-Ribose-Acceptor Hydrolases
Cells, 2022 The ARH family of ADP-ribose-acceptor hydrolases consists of three 39-kDa members (ARH1-3), with similarities in amino acid sequence. ARH1 was identified based on its ability to cleave ADP-ribosyl-arginine synthesized by cholera toxin.
Hiroko Ishiwata-Endo +6 more
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NAD+ Degrading Enzymes, Evidence for Roles During Infection
Frontiers in Molecular Biosciences, 2021 Declines in cellular nicotinamide adenine dinucleotide (NAD) contribute to metabolic dysfunction, increase susceptibility to disease, and occur as a result of pathogenic infection.
Arnold Tan, Craig L. Doig
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Molecular bases of catalysis and ADP-ribose preference of human Mn2+-dependent ADP-ribose/CDP-alcohol diphosphatase and conversion by mutagenesis to a preferential cyclic ADP-ribose phosphohydrolase. [PDF]
PLoS ONE, 2015 Among metallo-dependent phosphatases, ADP-ribose/CDP-alcohol diphosphatases form a protein family (ADPRibase-Mn-like) mainly restricted, in eukaryotes, to vertebrates and plants, with preferential expression, at least in rodents, in immune cells. Rat and
Alicia Cabezas +8 more
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Analysis of O-Acetyl-ADP-ribose as a Target for Nudix ADP-ribose Hydrolases [PDF]
Journal of Biological Chemistry, 2002 The Sir2 family of NAD(+)-dependent histone/protein deacetylases has been implicated in a wide range of biological activities, including gene silencing, life span extension, and chromosomal stability. Recent evidence has indicated that these proteins produce a novel metabolite O-acetyl-ADP-ribose (OAADPr) during deacetylation.
Louise A, Rafty +4 more
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Protein poly(ADP-ribosyl)ation regulates arabidopsis immune gene expression and defense responses. [PDF]
PLoS Genetics, 2015 Perception of microbe-associated molecular patterns (MAMPs) elicits transcriptional reprogramming in hosts and activates defense to pathogen attacks. The molecular mechanisms underlying plant pattern-triggered immunity remain elusive.
Baomin Feng +8 more
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