Results 21 to 30 of about 140,376 (246)

Stress-Induced PARP Activation Mediates Recruitment of Drosophila Mi-2 to Promote Heat Shock Gene Expression [PDF]

, 2011
Eukaryotic cells respond to genomic and environmental stresses, such as DNA damage and heat shock (HS), with the synthesis of poly-ADP-ribose] (PAR) at specific chromatin regions, such as DNA breaks or HS genes, by PAR polymerases (PARP). Little is known
Renate Renkawitz-Pohl, Hassler Markus, Murawska, Magdalena, Ladurner Andreas, Brehm Alexander, Andreas Ladurner, Renkawitz-Pohl, Renate, Brehm, Alexander, Ladurner, Andreas, Magdalena Murawska, Murawska Magdalena, Markus Hassler, Hassler, Markus, Alexander Brehm, Renkawitz-Pohl Renate   +14 more
core   +1 more source

Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. [PDF]

PLoS ONE, 2009
The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell signaling functions. In addition, extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a dominant cause of cell death in ...
David M Burns, Weihai Ying, Tiina M Kauppinen, Keqing Zhu, Raymond A Swanson   +4 more
doaj   +1 more source

Mitochondria are devoid of poly(ADP‐ribose)polymerase‐1, but harbor its product oligo(ADP‐ribose)

, 2021
There are conflicting data about localization of poly(ADP-ribose)polymerase-1 and its product poly(ADP-ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical and cell biological methods the potential presence of poly(
Christian Blenn, Beneke, Sascha, Julia Köritzer, Blenn, Christian, Alexander Bürkle, Sascha Beneke, Köritzer, Julia, Bürkle, Alexander   +7 more
core   +1 more source

Linking DNA repair and cell cycle progression through serine ADP-ribosylation of histones

Nature Communications, 2022
Poly(ADP-ribose)-polymerases (PARPs) are a cornerstone of the DNA damage response that promote DNA repair by modifying target proteins with ADP-ribose.
Julien Brustel, Tetsuya Muramoto, Kazuki Fumimoto, Jessica Ellins, Catherine J. Pears, Nicholas D. Lakin   +5 more
doaj   +1 more source

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription

Scientific Reports, 2018
Macrodomains are conserved protein folds associated with ADP-ribose binding and turnover. ADP-ribosylation is a posttranslational modification catalyzed primarily by ARTD (aka PARP) enzymes in cells.
Mareike Bütepage, Christian Preisinger, Alexander von Kriegsheim, Anja Scheufen, Eva Lausberg, Jinyu Li, Ferdinand Kappes, Regina Feederle, Sabrina Ernst, Laura Eckei, Sarah Krieg, Gerhard Müller-Newen, Giulia Rossetti, Karla L. H. Feijs, Patricia Verheugd, Bernhard Lüscher   +15 more
doaj   +1 more source

Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response

Life Science Alliance, 2021
This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
Danique Beijer, Thomas Agnew, Johannes Gregor Matthias Rack, Evgeniia Prokhorova, Tine Deconinck, Berten Ceulemans, Stojan Peric, Vedrana Milic Rasic, Peter De Jonghe, Ivan Ahel, Jonathan Baets   +10 more
doaj   +1 more source

Neurological and histological consequences induced by in vivo cerebral oxidative stress: evidence for beneficial effects of SRT1720, a sirtuin 1 activator, and sirtuin 1-mediated neuroprotective effects of poly(ADP-ribose) polymerase inhibition.

PLoS ONE, 2014
Poly(ADP-ribose)polymerase and sirtuin 1 are both NAD(+)-dependent enzymes. In vitro oxidative stress activates poly(ADP-ribose)polymerase, decreases NAD(+) level, sirtuin 1 activity and finally leads to cell death.
Cindy Gueguen, Bruno Palmier, Michel Plotkine, Catherine Marchand-Leroux, Valérie C Besson   +4 more
doaj   +1 more source

PARG suppresses tumorigenesis and downregulates genes controlling angiogenesis, inflammatory response, and immune cell recruitment

BMC Cancer, 2022
Chemokines are highly expressed in tumor microenvironment and play a critical role in all aspects of tumorigenesis, including the recruitment of tumor-promoting immune cells, activation of cancer-associated fibroblasts, angiogenesis, metastasis, and ...
Sarah Johnson, Yaroslava Karpova, Danping Guo, Atreyi Ghatak, Dmitriy A. Markov, Alexei V. Tulin   +5 more
doaj   +1 more source

Computational Bioprospecting Guggulsterone against ADP Ribose Phosphatase of SARS-CoV-2

Molecules, 2022
Coronavirus Disease-2019 (COVID-19) is a highly contagious disease caused by Severe Acute Respiratory Syndrome-Coronavirus-2 (SARS-CoV-2). The World Health Organization (WHO) classified the disease a as global public health hazard on 11 March 2020 ...
Mateusz Kciuk, Somdutt Mujwar, Isha Rani, Kavita Munjal, Adrianna Gielecińska, Renata Kontek, Kamal Shah   +6 more
doaj   +1 more source

Molecular Characterization of a Novel Intracellular ADP-Ribosyl Cyclase

, 2007
Background. ADP-ribosyl cyclases are remarkable enzymes capable of catalyzing multiple reactions including the synthesis of the novel and potent intracellular calcium mobilizing messengers, cyclic ADP-ribose and NAADP.
Jonathan S Marchant, Marchant, JS, Michael J Boulware, Dev Churamani, Churamani, D, Dale, L, Geach Timothy J., Martin Andrew C.R., Gary W Moy, Andrew C R Martin, Sandip Patel, Dale Leslie, Yi-Hsien Su, Vacquier, VD, Vacquier Victor D., Su, YH, Patel Sandip, Churamani Dev, Boulware, MJ, Marchant Jonathan S., Leslie Dale, Boulware Michael J., Moy Gary W., Patel, S, Geach, TJ, Su Yi-Hsien, Moy, GW, Timothy J Geach, Martin, ACR, Victor D Vacquier   +29 more
core   +1 more source