Engineering Af1521 improves ADP-ribose binding and identification of ADP-ribosylated proteins [PDF]
Nature Communications, 2020 ADP-ribose binding macro domains facilitate the enrichment and detection of cellular ADP-ribosylation. Here, the authors generate an engineered macro domain with increased ADP-ribose affinity, improving the identification of ADP-ribosylated proteins by ...
Kathrin Nowak +13 more
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Expanding the Substrate Specificity of Macro Domains toward 3″-Isomer of O‑Acetyl-ADP-ribose
, 2021 O-Acetyl-ADP-ribose (OAADPR) is a signaling molecule identified from the conserved sirtuin reaction in Saccharomyces cerevisiae, involved in the important cellular functions of gene silencing, redox regulation, and aging.
Yi-Chih Chiu +5 more
core +1 more source
ADP-Ribose Activates the TRPM2 Channel from the Sea Anemone Nematostella vectensis Independently of the NUDT9H Domain. [PDF]
PLoS ONE, 2016 The human redox-sensitive Transient receptor potential melastatin type 2 (hTRPM2) channel contains the C-terminal Nudix hydrolase domain NUDT9H which most likely binds ADP-ribose.
Frank J P Kühn +4 more
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Structural and Functional Characterization of Legionella pneumophila Effector MavL
Biomolecules, 2021 Legionella pneumophila is a Gram-negative intracellular pathogen that causes Legionnaires’ disease in elderly or immunocompromised individuals. This bacterium relies on the Dot/Icm (Defective in organelle trafficking/Intracellular multiplication) Type IV
Kevin Voth +6 more
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Structure of Mac1 N40D determined by X-ray crystallography in apo- and ADP-ribose-bound state.
, 2023 (A) Alignment of apo- (PDB code 8SH6) and ADP-ribose-bound N40D (PDB code 8SH8) structures shows previously identified structural changes occurring upon ADP-ribose binding (e.g.
Rahul K. Suryawanshi (2856155) +16 more
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Poly(ADP-Ribose) Links the DNA Damage Response and Biomineralization
Cell Reports, 2019 Summary: Biomineralization of the extracellular matrix is an essential, regulated process. Inappropriate mineralization of bone and the vasculature has devastating effects on patient health, yet an integrated understanding of the chemical and cell ...
Karin H. Müller +26 more
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Poly(ADP-ribose) polymerase family member 14 (PARP14) is a novel effector of the JNK2-dependent pro-survival signal in multiple myeloma [PDF]
, 2013 Copyright @ 2013 Macmillan Publishers Limited. This is the author's accepted manuscript. The final published article is available from the link below.Regulation of cell survival is a key part of the pathogenesis of multiple myeloma (MM).
Papa, S +9 more
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A Poly-ADP-Ribose Polymer–GCSF Conjugate
, 2022 Poly-ADP-ribose (PAR) is a naturally occurring form of polymers synthesized through enzymatic reactions catalyzed by poly(ADP-ribose) polymerases (PARPs). It is known for regulating various important cellular signaling pathways and processes.
Lei Zhang (38117) +5 more
core +1 more source
Inhibiting poly(ADP-ribosylation) improves axon regeneration
eLife, 2016 The ability of a neuron to regenerate its axon after injury depends in part on its intrinsic regenerative potential. Here, we identify novel intrinsic regulators of axon regeneration: poly(ADP-ribose) glycohodrolases (PARGs) and poly(ADP-ribose ...
Alexandra B Byrne +5 more
doaj +1 more source
Chromatin composition is changed by poly(ADP-ribosyl)ation during chromatin immunoprecipitation. [PDF]
PLoS ONE, 2012 Chromatin-immunoprecipitation (ChIP) employs generally a mild formaldehyde cross-linking step, which is followed by isolation of specific protein-DNA complexes and subsequent PCR testing, to analyze DNA-protein interactions.
Sascha Beneke +4 more
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