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Poly(ADP-ribose) Polymerase-1 in the Nervous System
Neurobiology of Disease, 2000 Poly(ADP-ribose) polymerase-1 (PARP-1) is a nuclear enzyme, activated by DNA strand breaks to participate in DNA repair. Overactivation of PARP by cellular insults depletes its substrate NAD+ and then ATP, leading to a major energy deficit and cell death.
Hyo Chol Ha, Solomon H. Snyder
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Poly ADP-ribose polymerase-1 and health
Experimental Biology and Medicine, 2010 Niacin (vitamin B 3 ) is required to form nicotinamide adenine dinucleotide (NAD) and nicotinamide adenine dinucleotide phosphate (NADP), which are involved in scores of anabolic and catabolic redox reactions throughout metabolism. It is now understood that NAD +
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PARP1 and PARG Are the Draft Horses for Polycomb-Trithorax Chromatin Regulator Machinery
BiomoleculesDuring tissue differentiation, gene expression patterns are committed to the epigenetic cellular memory machinery, including Polycomb and Trithorax groups (PcG and TrxG), which label chromatin with repressive or active histone marks.
Guillaume Bordet, Alexei V. Tulin
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Poly (ADP-Ribose) Polymerase Mediates Diabetes-Induced Retinal Neuropathy
Mediators of Inflammation, 2013 Retinal neuropathy is an early event in the development of diabetic retinopathy. One of the potential enzymes that are activated by oxidative stress in the diabetic retina is poly (ADP-ribose) polymerase (PARP).
Ghulam Mohammad +2 more
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Communications BiologyThe formation of nuclear biomolecular condensates is often associated with local accumulation of proteins at a site of DNA damage. The key role in the formation of DNA repair foci belongs to PARP1, which is a sensor of DNA damage and catalyzes the ...
Maria V. Sukhanova +4 more
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BMC Plant Biology, 2019 Background Poly (ADP-ribosyl) ation (PARylation) is an important posttranslational modification that regulates DNA repair, gene transcription, stress responses and developmental processes in multicellular organisms.
Zongying Gu +7 more
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Poly (ADP-ribose) polymerase inhibitors in cancer therapy
Chinese Medical Journal. Poly(ADP-ribose) polymerase (PARP) inhibitors (PARPis) have emerged as critical agents for cancer therapy. By inhibiting the catalytic activity of PARP enzymes and trapping them in the DNA, PARPis disrupt DNA repair, ultimately leading to cell death ...
Ziqi Zhu, Yujun Shi, Jing Ni
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Regulation of chromatin structure by poly(ADP-ribosyl)ation
Frontiers in Genetics, 2012 The interaction of DNA with proteins in the context of chromatin has to be tightly regulated to achieve so different tasks as packaging, transcription, replication and repair.
Sascha eBeneke
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Poly(ADP-Ribose) Polymerases [PDF]
The American Journal of Pathology, 2016 Neus Martínez-Bosch +3 more
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Reviews in Cardiovascular MedicineThe Poly(ADP-ribose) polymerase (PARP) family comprises seventeen members that catalyze poly- or mono- adenosine diphosphate (ADP)-ribosylation, a pivotal post-translational modification regulating a wide array of cellular processes, including ...
Jie Ma +8 more
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