Mitochondria are devoid of poly(ADP‐ribose)polymerase‐1, but harbor its product oligo(ADP‐ribose)
, 2021 There are conflicting data about localization of poly(ADP-ribose)polymerase-1 and its product poly(ADP-ribose) in mitochondria. To finally clarify the discussion, we investigated with biochemical and cell biological methods the potential presence of poly(
Christian Blenn +7 more
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Poly(ADP-Ribose) Polymerase (PARP) signaling of DNA damage induced by Topoisomerase 1 (TOP1) inhibition in carcinoma cells: chemotherapeutic implications of PARP and TOP1 inhibitors. [PDF]
, 2010 Una nuova strategia molecolare che incrementa l’azione antitumorale degli inibitori della Topoisomerasi 1 (TOP1) si basa sull’utilizzo di inibitori delle poli(ADP-ribosio) polimerasi (PARP).
D'Onofrio, Giovanna
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Nitrosative Stress as a Modulator of Inflammatory Change in a Model of Takotsubo Syndrome
JACC: Basic to Translational Science, 2018 Summary: Previous studies have shown that patients with Takotsubo syndrome (TS) have supranormal nitric oxide signaling, and post-mortem studies of TS heart samples revealed nitrosative stress.
Sven Y. Surikow, BHlthSc (Hons) +15 more
doaj +1 more source
Selective down-regulation of nuclear poly(ADP-ribose) glycohydrolase. [PDF]
PLoS ONE, 2009 The formation of ADP-ribose polymers on target proteins by poly(ADP-ribose) polymerases serves a variety of cell signaling functions. In addition, extensive activation of poly(ADP-ribose) polymerase-1 (PARP-1) is a dominant cause of cell death in ...
David M Burns +4 more
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Mcl-1 suppresses abasic site repair following bile acid–induced hepatic cellular DNA damage
Tumor Biology, 2017 In cholestasis, increases in bile acid levels result in the generation of reactive oxygen species and the induction of DNA damage and mutation. It is believed that bile acid accumulation is associated with liver tumorigenesis. However, the mechanism that
Haiyang Yu +11 more
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The relationship of the ADP-ribosylating enzyme from S. solfataricus with DING proteins and its intracellular localization [PDF]
, 2010 The PARPSso thermoprotein from Sulfolobus solfataricus has been identified as a PARP-like enzyme that cleaves -NAD+ to synthesize oligomers of ADP-ribose and cross-reacts with polyclonal anti-PARP-1 catalytic site antibodies.
Porzio, Elena
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Inputs and outputs of poly(ADP-ribosyl)ation: Relevance to oxidative stress
Redox Biology, 2014 Oxidative stress can cause DNA breaks which induce activation of the DNA nick sensor enzyme poly(ADP-ribose) polymerase-1 (PARP-1), part of the 17 member PARP enzyme family.
Csaba Hegedűs, László Virág
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Mutation landscape of germline and somatic BRCA1/2 in patients with high-grade serous ovarian cancer
BMC Cancer, 2020 Background Poly (ADP-ribose) polymerase inhibitors targeting BRCA1/2 mutations are available for treating patients with high-grade serous ovarian cancer.
Kyung Jin Eoh +6 more
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Pyridazine Based Compounds with PARP-1 Inhibitory Activity
Archives of Pharmaceutical Sciences Ain Shams University, 2023 Pyridazine-containing compounds have been identified as potent PARP1 inhibitors. The PARP is a family of enzymes essential for many cellular processes such as DNA repair, genomic stability, and apoptosis, also known as poly(ADP-ribose) synthetases and ...
Norhan A. Abdelrahman +3 more
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Apoptosis in mouse fetal and neonatal oocytes during meiotic prophase one [PDF]
, 2007 Background The vast majority of oocytes formed in the fetal ovary do not survive beyond birth. Possible reasons for their loss include the elimination of non-viable genetic constitutions arising through meiosis, however, the ...
Geraldine M Hartshorne +5 more
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