Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors [PDF]
Pathogens, 2023 The worldwide public health and socioeconomic consequences caused by the COVID-19 pandemic highlight the importance of increasing preparedness for viral disease outbreaks by providing rapid disease prevention and treatment strategies.
Tryfon Zarganes - Tzitzikas +2 more
exaly +4 more sources
Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins [PDF]
Pathogens, 2023 Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses.
Andrew Ryan, Matthew D Daugherty
exaly +4 more sources
The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses [PDF]
Pathogens, 2022 Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines.
Anthony K L Leung +2 more
exaly +4 more sources
Viruses, 2023 Among the different drug targets of SARS-CoV-2, a multi-domain protein known as NSP3 is a critical element of the translational and replication machinery.
Fahd Al-Mulla +2 more
exaly +4 more sources
Screening assay to monitor mono-ADP-ribosylhydrolase activity of viral macrodomains in cells [PDF]
Communications BiologyMono-ADP-ribosylation, a modification of both proteins and nucleic acids, is implicated in innate immunity. Intracellularly, this modification is catalyzed by PARP enzymes, some induced in response to interferons.
Sarah Knapp +16 more
doaj +2 more sources
The Viral Macrodomain Counters Host Antiviral ADP-Ribosylation
Viruses, 2020 Macrodomains, enzymes that remove ADP-ribose from proteins, are encoded by several families of RNA viruses and have recently been shown to counter innate immune responses to virus infection.
Yousef M O Alhammad, Anthony Fehr
exaly +3 more sources
Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-Ribosyl Hydrolase Activity [PDF]
VirusesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly impacted public health due to high rates of transmissibility and mutation during the COVID-19 pandemic.
Crissey D. Cameron +3 more
doaj +2 more sources
The Mac1 ADP-ribosylhydrolase is a therapeutic target for SARS-CoV-2 [PDF]
eLifeSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) continues to pose a threat to public health. Current therapeutics remain limited to direct-acting antivirals that lack distinct mechanisms of action and are already showing signs of viral ...
Rahul K Suryawanshi +30 more
doaj +2 more sources
Computational and Structural Biotechnology Journal, 2022 ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes.
Johannes Gregor Matthias Rack +2 more
exaly +3 more sources
Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle [PDF]
Journal of VirologyAll coronaviruses (CoVs) encode a conserved macrodomain, termed Mac1, in non-structural protein 3 (nsp3) that binds and hydrolyzes ADP-ribose covalently attached to proteins.
Joseph J. O'Connor +9 more
doaj +2 more sources