Results 1 to 10 of about 4,884 (228)

Discovery and Development Strategies for SARS-CoV-2 NSP3 Macrodomain Inhibitors

Pathogens, 2023
The worldwide public health and socioeconomic consequences caused by the COVID-19 pandemic highlight the importance of increasing preparedness for viral disease outbreaks by providing rapid disease prevention and treatment strategies.
Marion Schuller, Stephane De Cesco, Daren Fearon   +2 more
exaly   +4 more sources

Structure-Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus-2 Nsp3 Macrodomain. [PDF]

Chembiochem
Viral macrodomains, which hydrolyze mono‐ADP‐ribosylated proteins to evade host immunity, represent emerging antiviral targets, yet their druggability remains underexplored.
Krishnathas R, Mineev KS, Fourkiotis NK, Touret F, Sideras-Bisdekis C, Tsika AC, Gande SL, Linhard V, Sreeramulu S, Lennartz F, Weiss MS, Coutard B, Spyroulias GA, Schwalbe H.   +13 more
europepmc   +3 more sources

Recurrent Loss of Macrodomain Activity in Host Immunity and Viral Proteins

Pathogens, 2023
Protein post-translational modifications (PTMs) are an important battleground in the evolutionary arms races that are waged between the host innate immune system and viruses.
Sofia Elena Delgado-Rodriguez, Andrew Ryan, Matthew D Daugherty   +2 more
exaly   +4 more sources

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain [PDF]

Nature Communications
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das   +8 more
doaj   +3 more sources

Recombinant infectious bronchitis virus containing mutations in non-structural proteins 10, 14, 15, and 16 and within the macrodomain provides complete protection against homologous challenge [PDF]

Journal of Virology
Infectious bronchitis virus (IBV) is the etiological agent of infectious bronchitis, an acute highly contagious economically important disease of chickens.
Sarah Keep, Katalin Foldes, Guilia Dowgier, Graham Freimanis, Chandana Tennakoon, Shafiyeel Chowdhury, Adam Rayment, James Kirk, Trinity Bakshi, Phoebe Stevenson-Leggett, Yana Chen, Paul Britton, Erica Bickerton   +12 more
doaj   +3 more sources

Screening assay to monitor mono-ADP-ribosylhydrolase activity of viral macrodomains in cells [PDF]

Communications Biology
Mono-ADP-ribosylation, a modification of both proteins and nucleic acids, is implicated in innate immunity. Intracellularly, this modification is catalyzed by PARP enzymes, some induced in response to interferons.
Sarah Knapp, Verena Weber, Maud Verheirstraeten, Ani Sabcheva, Tanner Wright, Lea Herkens, Lukas Hauser, Lea Hirschen, Alexandra Golzmann, Barbara Lippok, Sarah Krieg, Dana Ferraris, Stefan Knapp, Andreas G. Ladurner, Giulia Rossetti, Bernhard Lüscher, Patricia Korn   +16 more
doaj   +2 more sources

Targeting SARS-CoV-2 Macrodomain-1 to Restore the Innate Immune Response Using In Silico Screening of Medicinal Compounds and Free Energy Calculation Approaches

Viruses, 2023
Among the different drug targets of SARS-CoV-2, a multi-domain protein known as NSP3 is a critical element of the translational and replication machinery.
Anwar Mohammad, Eman Alshawaf, Hossein Arefanian, Sulaiman K. Marafie, Abbas Khan, Dong-Qing Wei, Fahd Al-Mulla, Jehad Abubaker   +7 more
doaj   +2 more sources

The Conserved Macrodomain Is a Potential Therapeutic Target for Coronaviruses and Alphaviruses

Pathogens, 2022
Emerging and re-emerging viral diseases pose continuous public health threats, and effective control requires a combination of non-pharmacologic interventions, treatment with antivirals, and prevention with vaccines.
Anthony K. L. Leung, Diane E. Griffin, Jürgen Bosch, Anthony R. Fehr   +3 more
doaj   +2 more sources

The SARS-CoV-2 Nsp3 macrodomain reverses PARP9/DTX3L-dependent ADP-ribosylation induced by interferon signaling

Journal of Biological Chemistry, 2021
SARS-CoV-2 non-structural protein 3 (Nsp3) contains a macrodomain that is essential for virus replication and is thus an attractive target for drug development.
Lilian Cristina Russo, Matos I A, Sven T Sowa   +2 more
exaly   +2 more sources

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection

MBio, 2016
ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets.
Anthony R Fehr, Rudragouda Channappanavar, Gytis Jankevicius   +2 more
exaly   +3 more sources