Results 41 to 50 of about 2,256 (152)

Chromosome structuring limits genome plasticity in Escherichia coli. [PDF]

PLoS Genetics, 2007
Chromosome organizations of related bacterial genera are well conserved despite a very long divergence period. We have assessed the forces limiting bacterial genome plasticity in Escherichia coli by measuring the respective effect of altering different ...
Emilie Esnault, Michèle Valens, Olivier Espéli, Frédéric Boccard   +3 more
doaj   +1 more source

Antiviral activity of myricetin glycosylated compounds isolated from Marcetia taxifolia against chikungunya virus

EXCLI Journal : Experimental and Clinical Sciences, 2023
The chikungunya virus (CHIKV) has produced epidemic outbreaks of significant public health impact. The clinical symptoms of this disease are fever, polyarthralgia, and skin rash, generally self-limiting, although patients may develop a chronic disabling ...
Ana Luisa Muñoz, Andrés Felipe Cuéllar, Gabriela Arévalo, Brian David Santamaría, Anny K. Rodríguez, Cristian Buendía-Atencio, Andrés Reyes Chaparro, Aldo Yair Tenorio Barajas, Nydia Alexandra Segura, Felio Bello, Alírica Suárez, Hector R. Rangel, Mónica Losada-Barragán   +12 more
doaj   +1 more source

Structural Insights into Plasticity and Discovery of Remdesivir Metabolite GS-441524 Binding in SARS-CoV-2 Macrodomain

, 2022
S.603-609The nsP3 macrodomain is a conserved protein interaction module that plays essential regulatory roles in the host immune response by recognizing and removing posttranslational ADP-ribosylation sites during SARS-CoV-2 infection.
Ni, X., Chaikuad, A., Schröder, M., Hernandez-Olmos, V., Sharpe, M.E., Knapp, S., Olieric, V., Proschak, E., Merk, D.   +8 more
core   +1 more source

Eugenol‐Derived Piperazine Mannich Bases as Selective Inhibitors of Mayaro Virus: In Vitro Antiviral Evaluation and Mechanistic Insights

Journal of Medical Virology, Volume 98, Issue 9, September 2026.
ABSTRACT Arboviruses represent an ongoing global health challenge, particularly in tropical regions where diseases caused by Chikungunya virus (CHIKV) and Mayaro virus (MAYV) continue to emerge. Given the absence of licensed antiviral therapies, the identification of effective small molecules remains critical.
Adriana Cotta Cardoso Reis, Amália Luíza de Sousa da Silva, Camila Portruneli, Augusto Vieira Pontes Silva, Saulo Fehelberg Pinto Braga, Igor Rodrigues Lapa, Thiago Belarmino de Souza, Lucas Lopardi Franco, Diogo Teixeira Carvalho, Geraldo Célio Brandão   +9 more
wiley   +1 more source

Long range chromosome organization in Escherichia coli: The position of the replication origin defines the non-structured regions and the Right and Left macrodomains. [PDF]

PLoS Genetics, 2017
The Escherichia coli chromosome is organized into four macrodomains (Ori, Ter, Right and Left) and two non-structured regions. This organization influences the segregation of sister chromatids, the mobility of chromosomal DNA, and the cellular ...
Stéphane Duigou, Frédéric Boccard
doaj   +1 more source

Thermally Induced Evolution of the Local Structural Behavior in BiFeO3‐BaTiO3‐Based Ceramics

Journal of the American Ceramic Society, Volume 109, Issue 7, July 2026.
ABSTRACT The environmental urgency to replace toxic lead‐based piezoelectrics like Pb(Zr,Ti)O3 has driven the development of lead‐free alternatives such as BiFeO3–BaTiO3 ceramics. While macroscopic structural optimization has yielded promising electrostrain performance, the role of the local structure remains underexplored.
Hareem Zubairi, Mustapha Zaghrioui, Mingchen Gong, Anna Katharina Ott, Khalid Ait Ali, Fabien Giovannelli, Guillaume F. Nataf, Ge Wang   +7 more
wiley   +1 more source

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

Nature Communications
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das   +8 more
doaj   +1 more source

Recombinant infectious bronchitis virus containing mutations in non-structural proteins 10, 14, 15, and 16 and within the macrodomain provides complete protection against homologous challenge

Journal of Virology
Infectious bronchitis virus (IBV) is the etiological agent of infectious bronchitis, an acute highly contagious economically important disease of chickens.
Sarah Keep, Katalin Foldes, Guilia Dowgier, Graham Freimanis, Chandana Tennakoon, Shafiyeel Chowdhury, Adam Rayment, James Kirk, Trinity Bakshi, Phoebe Stevenson-Leggett, Yana Chen, Paul Britton, Erica Bickerton   +12 more
doaj   +1 more source

Molecular Insights into Poly(ADP-ribose) Recognition and Processing

Biomolecules, 2012
Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel, Eva Barkauskaite, Roko Žaja, Andreja Mikoč   +3 more
doaj   +1 more source

Record Energy Storage Performance Metrics in Ferroelectric Hafnia‐Based Films through Heterostructure Design

Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.
Dielectric capacitors typically struggle to achieve both high energy storage density and high efficiency at applied voltages below 10 V. Here, we address this challenge by introducing a novel hybrid fluorite/perovskite heterostructure design that combines ultra‐high recoverable energy storage density with efficient energy release (Uf ≈ 1016 J/cm3), at ...
Ampattu R. Jayakrishnan, Nuno Estrócio, Inês Silva, Raluca Negrea, Marian C. Istrate, Koppole C. Sekhar, Luís Marques, Judith L. MacManus‐Driscoll, Ignasi Fina, Florencio Sánchez, José P. B. Silva   +10 more
wiley   +1 more source