Results 41 to 50 of about 4,884 (228)
Viruses, 2022 Chikungunya virus (CHIKV) causes outbreaks of rash, arthritis, and fever associated with neurologic complications, where astrocytes are preferentially infected.
Taewoo Kim +4 more
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Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis [PDF]
Trends in Microbiology, 2018 Viruses from the Coronaviridae, Togaviridae, and Hepeviridae families all contain genes that encode a conserved protein domain, called a macrodomain; however, the role of this domain during infection has remained enigmatic. The recent discovery that mammalian macrodomain proteins enzymatically remove ADP-ribose, a common post-translation modification,
Fehr, A +3 more
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Evidence for divisome localization mechanisms independent of the Min system and SlmA in Escherichia coli. [PDF]
PLoS Genetics, 2014 Cell division in Escherichia coli starts with assembly of FtsZ protofilaments into a ring-like structure, the Z-ring. Positioning of the Z-ring at midcell is thought to be coordinated by two regulatory systems, nucleoid occlusion and the Min system. In E.
Matthew W Bailey +4 more
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Emerging Concepts on the Role of ADP-Ribosylation
Challenges, 2020 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways, since it acts as a key regulator of cellular and organism homeostasis.
Palmiro Poltronieri
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Anisotropy of exchange stiffness and its effect on the properties of magnets [PDF]
, 2003 Using the spin-spiral formulation of the tight-binding linear muffin-tin orbital method, the principal components of the exchange stiffness tensor are calculated for typical hard magnets including tetragonal CoPt-type and hexagonal YCo5 alloys.
Andersen +54 more
core +3 more sources
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
IUCrJ, 2020 Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska +6 more
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Host ADP-ribosylation and the SARS-CoV-2 macrodomain [PDF]
Biochemical Society Transactions, 2021 The COVID-19 pandemic has prompted intense research efforts into elucidating mechanisms of coronavirus pathogenesis and to propose antiviral interventions. The interferon (IFN) response is the main antiviral component of human innate immunity and is actively suppressed by several non-structural SARS-CoV-2 proteins, allowing viral replication within ...
openaire +2 more sources
IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
Pathogens, 2023 Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids
Katharina Biaesch +2 more
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An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors
Pathogens, 2023 Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose binding
Joseph J. O’Connor +2 more
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Copolymer-homopolymer blends: global energy minimisation and global energy bounds [PDF]
, 2007 We study a variational model for a diblock-copolymer/homopolymer blend. The energy functional is a sharp-interface limit of a generalisation of the Ohta-Kawasaki energy.
Peletier, Mark A., van Gennip, Yves
core +5 more sources