Results 1 to 10 of about 135 (83)

An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors

Pathogens, 2023
Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose binding
Dana Ferraris, Anthony Fehr, Fehr Anthony R   +2 more
exaly   +3 more sources

Mac1-Dependent Copper Sensing Promotes Histoplasma Adaptation to the Phagosome during Adaptive Immunity

MBio, 2022
Intracellular pathogens residing within macrophage phagosomes are challenged with recognizing the phagosomal environment and appropriately responding to changing host defense strategies imposed in this organelle.
Chad Rappleye, Stephanie C Ray
exaly   +3 more sources

Structure-Based High-Throughput Virtual Screening and Molecular Dynamics Simulation for the Discovery of Novel SARS-CoV-2 NSP3 Mac1 Domain Inhibitors

Viruses, 2023
Since the emergence of SARS-CoV-2, many genetic variations within its genome have been identified, but only a few mutations have been found in nonstructural proteins (NSPs).
Simone Brogi, Vincenzo Calderone, Behnaz Yazdani   +2 more
exaly   +3 more sources

Activation of the MAC1-ERK1/2-NOX2 Pathway Is Required for LPS-Induced Sustaining Reactive Microgliosis, Chronic Neuroinflammation and Neurodegeneration

Antioxidants, 2022
Recent studies suggest that improper resolution of acute neuroinflammation may lead to long-lasting low-grade chronic neuroinflammation and drive progressive neurodegeneration.
Jau-Shyong Hong, Shih-Heng Chen, Dezhen Tu   +2 more
exaly   +3 more sources

Microglial MAC1 receptor and PI3K are essential in mediating β-amyloid peptide-induced microglial activation and subsequent neurotoxicity

Journal of Neuroinflammation, 2011
Background β-Amyloid peptide (Aβ) is a major protein in the brain associated with Alzheimer's and Parkinson's diseases. The purpose of this study was to investigate the role of macrophage antigen-1 (MAC1) receptor, an integrin scavenger receptor in ...
, Jau-Shyong Hong, Shih-Heng Chen
exaly   +3 more sources

Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle

Journal of Virology
All coronaviruses (CoVs) encode a conserved macrodomain, termed Mac1, in non-structural protein 3 (nsp3) that binds and hydrolyzes ADP-ribose covalently attached to proteins.
Fei Gao, Anuradha Roy, Anthony Fehr
exaly   +3 more sources

Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation

Journal of Neuroinflammation, 2023
Introduction The mechanisms of cognitive impairments in Parkinson’s disease (PD) remain unknown. Accumulating evidence revealed that brain neuroinflammatory response mediated by microglial cells contributes to cognitive deficits in neuropathological ...
Liyan Hou, Jianing Liu, Fuqiang Sun, Ruixue Huang, Rui Chang, Zhengzheng Ruan, Ying Wang, Jie Zhao, Qingshan Wang   +8 more
doaj   +1 more source

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo.

PLoS Pathogens, 2023
Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target.
Taha Y Taha, Rahul K Suryawanshi, Irene P Chen, Galen J Correy, Maria McCavitt-Malvido, Patrick C O'Leary, Manasi P Jogalekar, Morgan E Diolaiti, Gabriella R Kimmerly, Chia-Lin Tsou, Ronnie Gascon, Mauricio Montano, Luis Martinez-Sobrido, Nevan J Krogan, Alan Ashworth, James S Fraser, Melanie Ott   +16 more
doaj   +1 more source

Nitric oxide-mediated antioxidative mechanism in yeast through the activation of the transcription factor Mac1. [PDF]

PLoS ONE, 2014
The budding yeast Saccharomyces cerevisiae possesses various defense mechanisms against environmental stresses that generate reactive oxygen species, leading to growth inhibition or cell death.
Ryo Nasuno, Miho Aitoku, Yuki Manago, Akira Nishimura, Yu Sasano, Hiroshi Takagi   +5 more
doaj   +1 more source

Regulation of Copper Metabolism by Nitrogen Utilization in Saccharomyces cerevisiae

Journal of Fungi, 2021
To understand the relationship between carbon or nitrogen utilization and iron homeostasis, we performed an iron uptake assay with several deletion mutants with partial defects in carbon or nitrogen metabolism. Among them, some deletion mutants defective
Suzie Kang, Hyewon Seo, Min-Gyu Lee, Cheol-Won Yun   +3 more
doaj   +1 more source