Results 21 to 30 of about 5,596 (181)

Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells [PDF]

ACS Chemical Biology, 2016
The genetic integrity of each organism is intimately tied to the correct segregation of its genome during mitosis. Insights into the underlying mechanisms are fundamental for both basic research and the development of novel strategies to treat mitosis-relevant diseases such as cancer.
Naowras, Al-Obaidi, Timothy J, Mitchison, Craig M, Crews, Thomas U, Mayer   +3 more
openaire   +3 more sources

Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion [PDF]

Journal of Leukocyte Biology, 2017
Abstract There is compelling evidence that circulatory hemodynamics prevent neutrophil activation, including adhesion to microvessels, in the microcirculation. However, the underlying mechanism or mechanisms by which that mechanoregulation occurs remain unresolved.
Akenhead, Michael L, Fukuda, Shunichi, Schmid‐Schoünbein, Geert W, Shin, Hainsworth Y   +3 more
openaire   +6 more sources

Effects of extracellular metabolic acidosis and out-of-equilibrium CO₂/HCO₃ ^- solutions on intracellular pH in cultured rat hippocampal neurons. [PDF]

Front Physiol
Metabolic acidosis (MAc)—an extracellular pH (pHo) decrease caused by a [HCO3−]o decrease at constant [CO2]o—usually causes intracellular pH (pHi) to fall.
Bouyer PG, Salameh AI, Zhou Y, Kolba TN, Boron WF.   +4 more
europepmc   +2 more sources

Recombinant infectious bronchitis virus containing mutations in non-structural proteins 10, 14, 15, and 16 and within the macrodomain provides complete protection against homologous challenge. [PDF]

J Virol
Infectious bronchitis virus (IBV) is the etiological agent of infectious bronchitis, an acute highly contagious economically important disease of chickens.
Keep S, Foldes K, Dowgier G, Freimanis G, Tennakoon C, Chowdhury S, Rayment A, Kirk J, Bakshi T, Stevenson-Leggett P, Chen Y, Britton P, Bickerton E.   +12 more
europepmc   +2 more sources

Copper acquisition is essential for plant colonization and virulence in a root-infecting vascular wilt fungus. [PDF]

PLoS Pathog
Plant pathogenic fungi provoke devastating agricultural losses and are difficult to control. How these organisms acquire micronutrients during growth in the host environment remains poorly understood.
Palos-Fernández R, Aguilar-Pontes MV, Puebla-Planas G, Berger H, Studt-Reinhold L, Strauss J, Di Pietro A, López-Berges MS.   +7 more
europepmc   +2 more sources

Monocyte-Derived Macrophages-Synovial Fibroblasts Crosstalk Unravels Oncostatin Signaling Network as a Driver of Synovitis in Osteoarthritis. [PDF]

Arthritis Rheumatol
Objective Osteoarthritis (OA) is a debilitating joint disease that is characterized by cartilage degradation, synovial inflammation, and pain. Macrophages have been implicated in OA pathology, but the origins and functions of diverse macrophage subsets seeding the synovial joint tissue remain incompletely understood.
Laouteouet D, Bortolotti O, Marineche L, Hannemann N, Chambon M, Glasson Y, Dumé AS, De Lima J, Fournial M, Touchet D, Séverac D, Leccia F, Duperray C, Michaud HA, Djouad F, Le Goff B, Blanchard F, Apparailly F, Courties G.   +18 more
europepmc   +2 more sources

High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain [PDF]

ACS Chemical Biology, 2021
Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a promising target for antiviral therapy.
Morgan Dasovich, Junlin Zhuo, Jack A. Goodman, Ajit Thomas, Robert Lyle McPherson, Aravinth Kumar Jayabalan, Veronica F. Busa, Shang-Jung Cheng, Brennan A. Murphy, Karli R. Redinger, Yousef M. O. Alhammad, Anthony R. Fehr, Takashi Tsukamoto, Barbara S. Slusher, Jürgen Bosch, Huijun Wei, Anthony K. L. Leung   +16 more
openaire   +4 more sources

The mac1 Gene: Controlling the Commitment to the Meiotic Pathway in Maize [PDF]

Genetics, 1996
Abstract The switch from the vegetative to the reproductive pathway of development in flowering plants requires the commitment of the subepidermal cells of the ovules and anthers to enter the meiotic pathway. These cells, the hypodermal cells, either directly or indirectly form the archesporial cells that, in turn, differentiate into the
W F, Sheridan, N A, Avalkina, I I, Shamrov, T B, Batygina, I N, Golubovskaya   +4 more
openaire   +2 more sources

Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation

Journal of Neuroinflammation, 2023
Introduction The mechanisms of cognitive impairments in Parkinson’s disease (PD) remain unknown. Accumulating evidence revealed that brain neuroinflammatory response mediated by microglial cells contributes to cognitive deficits in neuropathological ...
Liyan Hou, Jianing Liu, Fuqiang Sun, Ruixue Huang, Rui Chang, Zhengzheng Ruan, Ying Wang, Jie Zhao, Qingshan Wang   +8 more
doaj   +1 more source

The Yeast Transcription Factor Mac1 Binds to DNA in a Modular Fashion [PDF]

Journal of Biological Chemistry, 1999
Mac1 is a metalloregulatory protein that regulates expression of the high affinity copper transport system in the yeast Saccharomyces cerevisiae. Under conditions of high copper concentration, Mac1 represses transcription of genes coding for copper transport proteins.
C P, Jamison McDaniels, L T, Jensen, C, Srinivasan, D R, Winge, T D, Tullius   +4 more
openaire   +2 more sources