Results 21 to 30 of about 5,202 (155)

The mac1 Gene: Controlling the Commitment to the Meiotic Pathway in Maize [PDF]

Genetics, 1996
Abstract The switch from the vegetative to the reproductive pathway of development in flowering plants requires the commitment of the subepidermal cells of the ovules and anthers to enter the meiotic pathway. These cells, the hypodermal cells, either directly or indirectly form the archesporial cells that, in turn, differentiate into the
W F, Sheridan, N A, Avalkina, I I, Shamrov, T B, Batygina, I N, Golubovskaya   +4 more
openaire   +2 more sources

Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3 [PDF]

SLAS Discovery, 2020
ABSTRACT Small molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to coronavirus’ ability to evade cellular detection.
Rajdeep S. Virdi, Robert V. Bavisotto, Nicholas C. Hopper, Nemanja Vuksanovic, Trevor R. Melkonian, Nicholas R. Silvaggi, David N. Frick   +6 more
openaire   +5 more sources

The Yeast Transcription Factor Mac1 Binds to DNA in a Modular Fashion [PDF]

Journal of Biological Chemistry, 1999
Mac1 is a metalloregulatory protein that regulates expression of the high affinity copper transport system in the yeast Saccharomyces cerevisiae. Under conditions of high copper concentration, Mac1 represses transcription of genes coding for copper transport proteins.
C P, Jamison McDaniels, L T, Jensen, C, Srinivasan, D R, Winge, T D, Tullius   +4 more
openaire   +2 more sources

PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner

Journal of Virology, 2023
ABSTRACT ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD + to protein or nucleic acid substrates. This modification can be removed by several different types of proteins, including macrodomains.
Catherine M. Kerr, Srivatsan Parthasarathy, Nancy Schwarting, Joseph J. O’Connor, Emily Giri, Sunil More, Robin C. Orozco, Anthony R. Fehr   +7 more
openaire   +4 more sources

Copper Differentially Regulates the Activity and Degradation of Yeast Mac1 Transcription Factor [PDF]

Journal of Biological Chemistry, 1998
Copper is an essential metal ion that is toxic when accumulated to high intracellular concentrations. The yeast Mac1 protein is a copper-sensing transcription factor that is essential for both the activation and inactivation of genes required for high affinity copper ion transport.
Z, Zhu, S, Labbé, M M, Peña, D J, Thiele   +3 more
openaire   +2 more sources

The Location of the Antimicrobial Peptide Maculatin 1.1 in Model Bacterial Membranes

Frontiers in Chemistry, 2020
Maculatin 1.1 (Mac1) is an antimicrobial peptide (AMP) from the skin secretions of Australian tree frogs. In this work, the interaction of Mac1 with anionic phospholipid bilayers was investigated by NMR, circular dichroism (CD) spectroscopy, neutron ...
Anton P. Le Brun, Shiying Zhu, Marc-Antoine Sani, Frances Separovic   +3 more
doaj   +1 more source

Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus

Biochemical Journal, 2020
Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron ...
Annie Yap, Matthias Misslinger, Hubertus Haas   +2 more
openaire   +2 more sources

Identification of MAC1: A Small Molecule That Rescues Spindle Bipolarity in Monastrol-Treated Cells [PDF]

ACS Chemical Biology, 2016
The genetic integrity of each organism is intimately tied to the correct segregation of its genome during mitosis. Insights into the underlying mechanisms are fundamental for both basic research and the development of novel strategies to treat mitosis-relevant diseases such as cancer.
Naowras, Al-Obaidi, Timothy J, Mitchison, Craig M, Crews, Thomas U, Mayer   +3 more
openaire   +2 more sources

Cellular engagement of the SARS-CoV-2 macrodomain by GS-441524 and enhanced in vitro inhibition by its diphosphorylated metabolite [PDF]

RSC Chemical Biology
Coronavirus macrodomains (Mac1) counter host immunity by removing ADP-ribose. GS-441524, the parent nucleoside of remdesivir, inhibits SARS-CoV-2 Mac1, but its active metabolite and cellular engagement were undefined.
Banhi Biswas, Junlin Zhuo, Jürgen Bosch, Hien Vu, Lorencia Pak, Rameez Raja, Anuradha Roy, Alessandro Panattoni, Michal Maryska, Petr Slavik, Kryštof Šigut, Anthony R. Fehr, Rachy Abraham, Barbara S. Slusher, Takashi Tsukamoto, Anthony K. L. Leung   +15 more
doaj   +1 more source

Independent Metalloregulation of Ace1 and Mac1 in Saccharomyces cerevisiae

Eukaryotic Cell, 2005
ABSTRACT Ace1 and Mac1 undergo reciprocal copper metalloregulation in yeast cells. Mac1 is functional as a transcriptional activator in copper-deficient cells, whereas Ace1 is a transcriptional activator in copper-replete cells. Cells undergoing a transition from copper-deficient to copper-sufficient conditions through a switch in the growth ...
Greg, Keller, Amanda, Bird, Dennis R, Winge   +2 more
openaire   +2 more sources