Results 21 to 30 of about 10,490 (182)

The Location of the Antimicrobial Peptide Maculatin 1.1 in Model Bacterial Membranes

Frontiers in Chemistry, 2020
Maculatin 1.1 (Mac1) is an antimicrobial peptide (AMP) from the skin secretions of Australian tree frogs. In this work, the interaction of Mac1 with anionic phospholipid bilayers was investigated by NMR, circular dichroism (CD) spectroscopy, neutron ...
Anton P. Le Brun, Shiying Zhu, Marc-Antoine Sani, Frances Separovic   +3 more
doaj   +1 more source

Regulation of Copper Metabolism by Nitrogen Utilization in Saccharomyces cerevisiae

Journal of Fungi, 2021
To understand the relationship between carbon or nitrogen utilization and iron homeostasis, we performed an iron uptake assay with several deletion mutants with partial defects in carbon or nitrogen metabolism. Among them, some deletion mutants defective
Suzie Kang, Hyewon Seo, Min-Gyu Lee, Cheol-Won Yun   +3 more
doaj   +1 more source

The Yeast Transcription Factor Mac1 Binds to DNA in a Modular Fashion [PDF]

Journal of Biological Chemistry, 1999
Mac1 is a metalloregulatory protein that regulates expression of the high affinity copper transport system in the yeast Saccharomyces cerevisiae. Under conditions of high copper concentration, Mac1 represses transcription of genes coding for copper transport proteins.
C P, Jamison McDaniels, L T, Jensen, C, Srinivasan, D R, Winge, T D, Tullius   +4 more
openaire   +2 more sources

HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration [PDF]

The Journal of Neuroscience, 2011
What drives the gradual degeneration of dopamine neurons in Parkinson's disease (PD), the second most common neurodegenerative disease, remains elusive. Here, we demonstrated, for the first time, that persistent neuroinflammation was indispensible for such a neurodegenerative process. 1-Methyl-4-phenylpyridinium, lipopolysaccharide
Hui-Ming, Gao, Hui, Zhou, Feng, Zhang, Belinda C, Wilson, Wayneho, Kam, Jau-Shyong, Hong   +5 more
openaire   +2 more sources

Complement C3 Enhances LPS-Elicited Neuroinflammation and Neurodegeneration Via the Mac1/NOX2 Pathway

Molecular Neurobiology, 2023
AbstractRecent studies showed increased expression of complements in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. However, the mechanism regulating the expression of complements and their roles in the pathogenesis of neurodegeneration are unclear.
Ran Zhou, Shih-Heng Chen, Zhan Zhao, Dezhen Tu, Sheng Song, Yubao Wang, Qingshan Wang, Jing Feng, Jau-Shyong Hong   +8 more
openaire   +2 more sources

Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion [PDF]

Journal of Leukocyte Biology, 2017
Abstract There is compelling evidence that circulatory hemodynamics prevent neutrophil activation, including adhesion to microvessels, in the microcirculation. However, the underlying mechanism or mechanisms by which that mechanoregulation occurs remain unresolved.
Akenhead, Michael L, Fukuda, Shunichi, Schmid‐Schoünbein, Geert W, Shin, Hainsworth Y   +3 more
openaire   +4 more sources

The mac1 Gene: Controlling the Commitment to the Meiotic Pathway in Maize [PDF]

Genetics, 1996
Abstract The switch from the vegetative to the reproductive pathway of development in flowering plants requires the commitment of the subepidermal cells of the ovules and anthers to enter the meiotic pathway. These cells, the hypodermal cells, either directly or indirectly form the archesporial cells that, in turn, differentiate into the
W F, Sheridan, N A, Avalkina, I I, Shamrov, T B, Batygina, I N, Golubovskaya   +4 more
openaire   +2 more sources

Overexpression of Mcl-1 exacerbates lymphocyte accumulation and autoimmune kidney disease in lpr mice [PDF]

, 2016
Cell death by apoptosis has a critical role during embryonic development and in maintaining tissue homeostasis. In mammals, there are two converging apoptosis pathways: the ‘extrinsic’ pathway, which is triggered by engagement of cell surface ‘death ...
A Egle, A Enders, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Strasser, A Villunger, AE Weant, AR Delbridge, BA Croker, Cassandra J Vandenberg, DA Hildeman, DA Steimer, E Lagasse, E Schneider, EA Reap, EM Carrington, F Rieux-Laucat, GH Fisher, I Dzhagalov St, I Vikstrom, IN Lavrik, J Hutcheson, J Opferman, JI Fletcher, JJ Weening, JM Brouwer, JT Opferman, K Fecho, K Iwai, K Nakayama, KA Fortner, KD Mason, Kirsteen J Campbell, KJ Campbell, KL O'Neill, L Chen, Lorraine A O’Reilly, M Pellegrini, MN Martina, Natasha S Anstee, P Bouillet, P Hughes, PD Hughes, PE Czabotar, PE Czabotar, Peter D Hughes, PH Krammer, PL Cohen, R Watanabe-Fukunaga, RM Perciavalle, S Cory, S Ogilvy, SF Fischer, SN Willis, SN Willis, Suzanne Cory, T Kuwana, T Moldoveanu, TH Price, TJ McDonnell, V Peperzak, WC Liles, WF Davidson   +65 more
core   +15 more sources

Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3 [PDF]

Biochemistry, 2020
The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the RNA-dependent RNA polymerase, helicase, and main protease, are well conserved between SARS-CoV-2 and the original SARS virus, but several others are not. This study examines one
Frick, David N., Virdi, Rajdeep S., Vuksanovic, Nemanja, Dahal, Narayan, Silvaggi, Nicholas R.   +4 more
openaire   +3 more sources

Analysis of security protocols using finite-state machines [PDF]

, 2015
This paper demonstrates a comprehensive analysis method using formal methods such as finite-state machine. First, we describe the modified version of our new protocol and briefly explain the encrypt-then-authenticate mechanism, which is regarded as more ...
Aljeaid, D, Langensiepen, C, Ma, X
core   +1 more source