Publisher Correction: Design, structure-based optimization and antiviral evaluation of potent inhibitors for the macrodomain Mac1 of SARS-CoV-2 [PDF]
Nature CommunicationsMaximilian Sandmann +20 more
doaj +2 more sources
X-ray Crystallography-Guided Design and Synthesis of Cyclopentyl Heteroaryl Carboxylic Acid-Based Inhibitors of the SARS-CoV-2 Nsp3 Macrodomain (Mac1). [PDF]
J Med ChemMac1 is a conserved macrodomain enzyme in the nonstructural protein 3 (Nsp3) of SARS-CoV-2 and is part of the viral replication machinery. Mac1 is a target for small-molecule inhibitors that could ultimately enable new COVID-19 therapeutics to be ...
Wang X +16 more
europepmc +2 more sources
Regulation of Copper Metabolism by Nitrogen Utilization in Saccharomyces cerevisiae
Journal of Fungi, 2021 To understand the relationship between carbon or nitrogen utilization and iron homeostasis, we performed an iron uptake assay with several deletion mutants with partial defects in carbon or nitrogen metabolism. Among them, some deletion mutants defective
Suzie Kang +3 more
doaj +1 more source
Mac1 N40A protein is less stable in cells than are Mac1 WT or Mac1 N40D proteins.
, 2023 Western blot analyses of cell lysates from A549 lung cancer cells lentivirally transduced with vectors expressing Strep-tagged Mac1 WT, Mac1 N40D or Mac1 N40A proteins. β-actin is shown as a loading control.
Rahul K. Suryawanshi (2856155) +16 more
core +1 more source
The Location of the Antimicrobial Peptide Maculatin 1.1 in Model Bacterial Membranes
Frontiers in Chemistry, 2020 Maculatin 1.1 (Mac1) is an antimicrobial peptide (AMP) from the skin secretions of Australian tree frogs. In this work, the interaction of Mac1 with anionic phospholipid bilayers was investigated by NMR, circular dichroism (CD) spectroscopy, neutron ...
Anton P. Le Brun +3 more
doaj +1 more source
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening [PDF]
, 2022 The emergence of several zoonotic viruses in the last twenty years, especially the pandemic outbreak of SARS-CoV-2, has exposed a dearth of antiviral drug therapies for viruses with pandemic potential. Developing a diverse drug portfolio will be critical
Leung, A. K. (Anthony K. L.) +30 more
core +1 more source
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
IUCrJ, 2020 Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska +6 more
doaj +1 more source
Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target [PDF]
The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has made it clear that further development of antiviral therapies will be needed.
Fehr, Anthony R. +11 more
core +3 more sources
Journal of Oral Microbiology, 2023 Candida albicans is a normal resident of the human oral cavity. It is also the most common fungal pathogen, causing various oral diseases, particularly in immunocompromised individuals.
Qian Jiang +4 more
doaj +1 more source
mBio, 2022 Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng +9 more
doaj +1 more source