Results 11 to 20 of about 5,783 (150)

Nitric oxide-mediated antioxidative mechanism in yeast through the activation of the transcription factor Mac1. [PDF]

PLoS ONE, 2014
The budding yeast Saccharomyces cerevisiae possesses various defense mechanisms against environmental stresses that generate reactive oxygen species, leading to growth inhibition or cell death.
Ryo Nasuno, Miho Aitoku, Yuki Manago, Akira Nishimura, Yu Sasano, Hiroshi Takagi   +5 more
doaj   +2 more sources

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo. [PDF]

PLoS Pathogens, 2023
Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target.
Taha Y Taha, Rahul K Suryawanshi, Irene P Chen, Galen J Correy, Maria McCavitt-Malvido, Patrick C O'Leary, Manasi P Jogalekar, Morgan E Diolaiti, Gabriella R Kimmerly, Chia-Lin Tsou, Ronnie Gascon, Mauricio Montano, Luis Martinez-Sobrido, Nevan J Krogan, Alan Ashworth, James S Fraser, Melanie Ott   +16 more
doaj   +2 more sources

Molecular Characteristics of the Conserved Aspergillus nidulans Transcription Factor Mac1 and Its Functions in Response to Copper Starvation

mSphere, 2019
Copper (Cu) is an essential trace element in all organisms, and Cu acquisition during periods of starvation is important for cell survival and proliferation.
Zhendong Cai, Wenlong Du, Lianhong Liu, Daodong Pan, Ling Lu   +4 more
doaj   +2 more sources

Examining the Effects of the RUNX1 p.Leu43Ser Variant on FPD/AML Phenotypes Using a CRISPR/Cas9-Generated Knock-In Murine Model [PDF]

Biomolecules
Germline heterozygous variants in RUNX1 lead to Familial Platelet Disorder with Myeloid Leukemia Predisposition (FPD/AML). Cellular and/or animal models are helpful to uncovering the role of a variant in disease progression. Twenty-five mice per genotype
Ana Marin-Quilez, Ignacio García-Tuñón, Rocío Benito, José Luis Ordoñez, Lorena Díaz-Ajenjo, Ana Lama-Villanueva, Carmen Guerrero, Jesús Pérez-Losada, José Ramón González-Porras, Jesús María Hernández-Rivas, Mónica del Rey, José María Bastida   +11 more
doaj   +2 more sources

Molecular basis for loss of virulence in Magnaporthe oryzae strain AM16 [PDF]

Frontiers in Plant Science
The rapid virulence variation of Magnaporthe oryzae (M. oryzae) to rice is a big challenge for rice blast control. Even though many studies have been done by scientists all over the world, the mechanism of virulence variation in M. oryzae remains elusive.
Jiahui Deng, Ziya Zhang, Xingli Wang, Yongni Cao, Huichuan Huang, Mo Wang, Qiong Luo   +6 more
doaj   +2 more sources

Copper acquisition is essential for plant colonization and virulence in a root-infecting vascular wilt fungus. [PDF]

PLoS Pathogens
Plant pathogenic fungi provoke devastating agricultural losses and are difficult to control. How these organisms acquire micronutrients during growth in the host environment remains poorly understood.
Rafael Palos-Fernández, María Victoria Aguilar-Pontes, Gema Puebla-Planas, Harald Berger, Lena Studt-Reinhold, Joseph Strauss, Antonio Di Pietro, Manuel Sánchez López-Berges   +7 more
doaj   +2 more sources

Neuroprotective Potential of New Monoterpene-Adamatane Conjugates—A Pilot Study [PDF]

Current Issues in Molecular Biology
Neurodegenerative diseases, including Alzheimer’s disease, are marked by cholinergic dysfunction, oxidative stress, and reduced neurotrophic support, which drives the quest for multifunctional therapeutic agents.
Stela Dragomanova, Polina Petkova-Kirova, Konstantin Volcho, Jóhannes Reynisson, Valya Grigorova, Diamara Uzunova, Elina Tsvetanova, Almira Georgieva, Albena Alexandrova, Miroslava Stefanova, Borislav Minchev, Jesunifemi Popoola, Nora Chouha, Aldar Munkuev, Konstantin Ponomarev, Evgenyi Suslov, Nariman Salakhutdinov, Reni Kalfin, Lyubka Tancheva   +18 more
doaj   +2 more sources

Recombinant infectious bronchitis virus containing mutations in non-structural proteins 10, 14, 15, and 16 and within the macrodomain provides complete protection against homologous challenge [PDF]

Journal of Virology
Infectious bronchitis virus (IBV) is the etiological agent of infectious bronchitis, an acute highly contagious economically important disease of chickens.
Sarah Keep, Katalin Foldes, Guilia Dowgier, Graham Freimanis, Chandana Tennakoon, Shafiyeel Chowdhury, Adam Rayment, James Kirk, Trinity Bakshi, Phoebe Stevenson-Leggett, Yana Chen, Paul Britton, Erica Bickerton   +12 more
doaj   +2 more sources

SARS-CoV-2 Mac1 is an essential virulence factor [PDF]

, 2023
Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein.
Channappanavar, Rudragouda, More, Sunil, Kerr, Catherine M., Zúñiga Lucas, Sonia, Alhammad, Yousef M., Chanda, Debarati, Enjuanes Sánchez, Luis, Fehr, Anthony R., O'Connor, Joseph J., Unckless, Robert L., Miller, Caden A., Parthasarathy, Srivatsan, Pfannenstiel, Jessica J., Ghimire, Roshan   +13 more
core   +1 more source

Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation

Journal of Neuroinflammation, 2023
Introduction The mechanisms of cognitive impairments in Parkinson’s disease (PD) remain unknown. Accumulating evidence revealed that brain neuroinflammatory response mediated by microglial cells contributes to cognitive deficits in neuropathological ...
Liyan Hou, Jianing Liu, Fuqiang Sun, Ruixue Huang, Rui Chang, Zhengzheng Ruan, Ying Wang, Jie Zhao, Qingshan Wang   +8 more
doaj   +1 more source