mBio, 2022 Intracellular pathogens residing within macrophage phagosomes are challenged with recognizing the phagosomal environment and appropriately responding to changing host defense strategies imposed in this organelle.
Stephanie C. Ray, Chad A. Rappleye
doaj +3 more sources
Nitric oxide-mediated antioxidative mechanism in yeast through the activation of the transcription factor Mac1. [PDF]
PLoS ONE, 2014 The budding yeast Saccharomyces cerevisiae possesses various defense mechanisms against environmental stresses that generate reactive oxygen species, leading to growth inhibition or cell death.
Ryo Nasuno +5 more
doaj +4 more sources
A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo. [PDF]
PLoS Pathogens, 2023 Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target.
Taha Y Taha +16 more
doaj +4 more sources
Neuroprotective Potential of New Monoterpene-Adamatane Conjugates-A Pilot Study. [PDF]
Curr Issues Mol BiolNeurodegenerative diseases, including Alzheimer’s disease, are marked by cholinergic dysfunction, oxidative stress, and reduced neurotrophic support, which drives the quest for multifunctional therapeutic agents.
Dragomanova S +18 more
europepmc +2 more sources
Effects of extracellular metabolic acidosis and out-of-equilibrium CO<sub>2</sub>/HCO<sub>3</sub> <sup>-</sup> solutions on intracellular pH in cultured rat hippocampal neurons. [PDF]
Front PhysiolMetabolic acidosis (MAc)—an extracellular pH (pHo) decrease caused by a [HCO3−]o decrease at constant [CO2]o—usually causes intracellular pH (pHi) to fall.
Bouyer PG +4 more
europepmc +2 more sources
Recombinant infectious bronchitis virus containing mutations in non-structural proteins 10, 14, 15, and 16 and within the macrodomain provides complete protection against homologous challenge. [PDF]
J VirolInfectious bronchitis virus (IBV) is the etiological agent of infectious bronchitis, an acute highly contagious economically important disease of chickens.
Keep S +12 more
europepmc +2 more sources
Copper acquisition is essential for plant colonization and virulence in a root-infecting vascular wilt fungus. [PDF]
PLoS PathogPlant pathogenic fungi provoke devastating agricultural losses and are difficult to control. How these organisms acquire micronutrients during growth in the host environment remains poorly understood.
Palos-Fernández R +7 more
europepmc +2 more sources
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV-2 Mac1 Macrodomain [PDF]
ACS Chemical Biology, 2021 Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a promising target for antiviral therapy.
Morgan Dasovich +16 more
openaire +4 more sources
Journal of Medicinal Chemistry, 2023 AbstractThe COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has made it clear that further development of antiviral therapies will be needed to combat additional SARS-CoV-2 variants or novel CoVs. Here, we describe small molecule inhibitors for SARS-CoV-2 Mac1, which counters ADP-ribosylation mediated ...
Sarah Wazir +11 more
openaire +3 more sources
A differential genome-wide transcriptome analysis : impact of cellular copper on complex biological processes like aging and development [PDF]
, 2012 The regulation of cellular copper homeostasis is crucial in biology. Impairments lead to severe dysfunctions and are known to affect aging and development.
Grimm, Carolin +3 more
core +10 more sources