Nitric oxide-mediated antioxidative mechanism in yeast through the activation of the transcription factor Mac1. [PDF]
PLoS ONE, 2014 The budding yeast Saccharomyces cerevisiae possesses various defense mechanisms against environmental stresses that generate reactive oxygen species, leading to growth inhibition or cell death.
Ryo Nasuno +5 more
doaj +5 more sources
Molecular Characteristics of the Conserved
mSphere, 2019 Copper (Cu) is an essential trace element in all organisms, and Cu acquisition during periods of starvation is important for cell survival and proliferation.
Zhendong Cai +4 more
doaj +4 more sources
Discovery of 2-Amide-3-methylester Thiophenes that Target SARS-CoV-2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target [PDF]
Journal of Medicinal Chemistry, 2023 Abstract The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has made it clear that further development of antiviral therapies will be needed to combat additional SARS-CoV-2 variants or novel CoVs.
Sarah Wazir +11 more
openaire +4 more sources
Discovery of Drug-like Ligands for the Mac1 Domain of SARS-CoV-2 Nsp3 [PDF]
SLAS Discovery, 2020 ABSTRACT Small molecules that bind the SARS-CoV-2 non-structural protein 3 Mac1 domain in place of ADP-ribose could be useful as molecular probes or scaffolds for COVID-19 antiviral drug discovery because Mac1 has been linked to coronavirus’ ability to evade cellular detection.
Rajdeep S. Virdi +6 more
openaire +6 more sources
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice [PDF]
, 2023 ABSTRACT Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein. Utilizing point mutant recombinant viruses, Mac1 was shown to be critical for both murine
Yousef M. Alhammad +13 more
openaire +3 more sources
mBio, 2022 Intracellular pathogens residing within macrophage phagosomes are challenged with recognizing the phagosomal environment and appropriately responding to changing host defense strategies imposed in this organelle.
Stephanie C. Ray, Chad A. Rappleye
doaj +3 more sources
PLoS Pathogens, 2023 Despite unprecedented efforts, our therapeutic arsenal against SARS-CoV-2 remains limited. The conserved macrodomain 1 (Mac1) in NSP3 is an enzyme exhibiting ADP-ribosylhydrolase activity and a possible drug target.
Taha Y Taha +16 more
doaj +2 more sources
Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening [PDF]
Antiviral Research, 2022 ABSTRACT The emergence of several zoonotic viruses in the last twenty years, especially the pandemic outbreak of SARS-CoV-2, has exposed a dearth of antiviral drug therapies for viruses with pandemic potential.
Anu Roy +9 more
openaire +8 more sources
HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration [PDF]
The Journal of Neuroscience, 2011 What drives the gradual degeneration of dopamine neurons in Parkinson's disease (PD), the second most common neurodegenerative disease, remains elusive. Here, we demonstrated, for the first time, that persistent neuroinflammation was indispensible for such a neurodegenerative process. 1-Methyl-4-phenylpyridinium, lipopolysaccharide
Hui-Ming, Gao +5 more
openaire +3 more sources
Structures of the Cuprous-Thiolate Clusters of the Mac1 and Ace1 Transcriptional Activators
Biochemistry, 2002 X-ray absorption spectroscopy on the minimal copper-regulatory domains of the two copper-regulated transcription factors (Ace1 and Mac1) in Saccharomyces cerevisiae revealed the presence of a remarkably similar polycopper cluster in both proteins. The Cu-regulatory switch motif of Mac1 consisting of the C-terminal first Cys-rich motif, designated the ...
Brown, K. +5 more
openaire +4 more sources