Zn(II) and Cd(II) Complexes of AMT1/MAC1 Homologous Cys/His-Rich Domains: So Similar yet So Different [PDF]
Infections caused by Candida species are becoming seriously dangerous and difficult to cure due to their sophisticated mechanisms of resistance. The host organism defends itself from the invader, e.g., by increasing the concentration of metal ions. Therefore, there is a need to understand the overall mechanisms of metal homeostasis in Candida species ...
Anna Rola +4 more
openaire +2 more sources
EBF1-deficient bone marrow stroma elicits persistent changes in HSC potential
Crosstalk between mesenchymal stromal cells (MSCs) and hematopoietic stem cells (HSCs) is essential for hematopoietic homeostasis and lineage output. Here, we investigate how transcriptional changes in bone marrow (BM) MSCs result in long-lasting effects
Cauchy, P. +6 more
core +1 more source
Cytological characterization and allelism testing of anther developmental mutants identified in a screen of maize male sterile lines. [PDF]
Proper regulation of anther differentiation is crucial for producing functional pollen, and defects in or absence of any anther cell type result in male sterility.
Cande, William Zacheus +7 more
core +2 more sources
Transmission of the New World hemorrhagic fever arenaviruses Junín virus (JUNV) and Machupo virus (MACV) to humans is facilitated, in part, by the interaction between the arenavirus GP1 glycoprotein and the human transferrin receptor 1 (hTfR1).
Weng M. Ng +9 more
doaj +1 more source
Functional Independence of the Two Cysteine-rich Activation Domains in the Yeast Mac1 Transcription Factor [PDF]
Mac1 is a transcriptional activator whose activity is inhibited by copper ions. Mutagenesis studies were carried out to map residues important in the copper inhibition of Mac1 activity. Seven new missense mutations were identified that resulted in copper-independent Mac1 transcriptional activation.
G, Keller +3 more
openaire +2 more sources
In-cell DNP NMR reveals multiple targeting effect of antimicrobial peptide
Dynamic nuclear polarization NMR spectroscopy was used to investigate the effect of the antimicrobial peptide (AMP) maculatin 1.1 on E. coli cells. The enhanced 15N NMR signals from nucleic acids, proteins and lipids identified a number of unanticipated ...
Frances Separovic +4 more
doaj +1 more source
Generalization of the Macdonald formula for Hall-Littlewood polynomials [PDF]
We study the Gaussent-Littelmann formula for Hall-Littlewood polynomials and we develop combinatorial tools to describe the formula in a purely combinatorial way for type A_n, B_n and C_n.
Klostermann, Inka
core +2 more sources
Copper homeostasis is an important determinant for virulence of many human pathogenic fungi such as the highly prevalent yeast Candida albicans. However, beyond the copper transporter Ctr1, little is known regarding other genes and biological processes ...
Inès Khemiri +3 more
doaj +1 more source
Virulence attributes and hyphal growth of C. neoformans are quantitative traits and the MATalpha allele enhances filamentation. [PDF]
Cryptococcus neoformans is a fungal human pathogen with a bipolar mating system. It undergoes a dimorphic transition from a unicellular yeast to hyphal filamentous growth during mating and monokaryotic fruiting. The traditional sexual cycle that leads to
Xiaorong Lin +3 more
doaj +1 more source
Results from the MAC1 Vertex Chamber [PDF]
In the summer of 1983, the MAC and Mark-II collaborations gave evidence for bottom hadron lifetimes or 1–2 ps2 based on data accumulated at the PEP e + e − storage ring at SLAC. The importance and fundamental nature of this measurement3 prompted the MAC collaboration to propose, in autumn 1983, the addition of a high precision vertex chamber to the MAC
openaire +1 more source

