Results 61 to 70 of about 10,490 (182)

A guide to the types, structures, and multifaceted functions of matrix metalloproteinases in cancer

The FEBS Journal, EarlyView.
Matrix metalloproteinases (MMPs) orchestrate cancer progression and metastasis through proteolytic and non‐proteolytic actions. By remodeling the tumor microenvironment, enhancing growth factor availability, and modulating cell behavior, MMPs promote proliferation, migration or invasion, and epithelial‐to‐mesenchymal transition. Alongside extracellular
Zoi Piperigkou, Sylvia Mangani, Spyros Kremmydas, Nikolaos E. Koletsis, Nikos K. Karamanos   +4 more
wiley   +1 more source

SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice

, 2023
ABSTRACTSeveral coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein. Utilizing point mutant recombinant viruses, Mac1 was shown to be critical for both murine hepatitis virus (
Yousef M. Alhammad, Srivatsan Parthasarathy, Roshan Ghimire, Joseph J. O’Connor, Catherine M. Kerr, Jessica J. Pfannenstiel, Debarati Chanda, Caden A. Miller, Robert L. Unckless, Sonia Zuniga, Luis Enjuanes, Sunil More, Rudragouda Channappanavar, Anthony R. Fehr   +13 more
openaire   +2 more sources

Mac-1 Receptor Clustering Initiates Production of Pro-Inflammatory, Antibacterial Extracellular Vesicles From Neutrophils

Frontiers in Immunology, 2021
Depending on the prevailing environmental conditions, neutrophilic granulocytes release extracellular vesicles (EV) which have either anti-inflammatory effects on other neutrophils or pro-inflammatory and antibacterial effects.
Viktória Szeifert, Ferenc Kolonics, Balázs Bartos, Delaram Khamari, Pál Vági, László Barna, Erzsébet Ligeti, Ákos M. Lőrincz, Ákos M. Lőrincz   +8 more
doaj   +1 more source

Obesity Disrupts H3K4me3‐Mediated Lactate Accumulation and Efferocytosis in Hypoxic Macrophages

The FASEB Journal, Volume 40, Issue 7, 15 April 2026.
Obesity disrupts macrophage adaptation to hypoxic microenvironments. In lean conditions, hypoxia induces H3K4me3‐dependent transcriptional programs that promote lactate accumulation, histone lactylation, and efficient efferocytosis. Diet‐induced obesity impairs this epigenetic–metabolic response, resulting in reduced lactate accumulation, defective ...
Kentaro Takahashi, Julia Drolet, Jinghua Liu, Jasmine R. Jackson, Madison Babcock, Muthusamy Thiruppathi, Milie Fang, Tyler Paul, Gayathri Ganesh, Yuri Fukasawa, Yoshikiyo Akasaka, Giamila Fantuzzi, Elizaveta V. Benevolenskaya, Timothy J. Koh, Norifumi Urao   +14 more
wiley   +1 more source

The Development and creation of a software system for the monitoring system MAC1

International Journal of Mathematics and Physics, 2019
Abstract. A special system of acoustic detectors was created to search for possible correlations between wide air showers and the signal of elastic oscillations from the depths of the earth's crust. They are intended for joint synchronous work with storm installation.
B. A. Iskakov, Y. M. Tautayev, T. X. Sadykov, A. L. Shepetov, N. M. Salikhov   +4 more
openaire   +2 more sources

Histone demethylase Lsd1 represses hematopoietic stem and progenitor cell signatures during blood cell maturation [PDF]

, 2014
Here, we describe that lysine-specific demethylase 1 (Lsd1/KDM1a), which demethylates histone H3 on Lys4 or Lys9 (H3K4/K9), is an indispensible epigenetic governor of hematopoietic differentiation. Integrative genomic analysis, combining global occupancy
Fujiwara, Yuko, Guo, Guoji, Hsu, Yu-Jung, Kerenyi, Marc A, Luc, Sidinh, Nguyen, Minh, O'Brien, Kassandra, Orkin, Stuart H, Peng, Cong, Shao, Zhen   +9 more
core   +1 more source

Conformational stability analyses of alpha subunit I domain of LFA-1 and Mac-1. [PDF]

PLoS ONE, 2011
β₂ integrin of lymphocyte function-associated antigen-1 (LFA-1) or macrophage-1 antigen (Mac-1) binds to their common ligand of intercellular adhesion molecule-1 (ICAM-1) and mediates leukocyte-endothelial cell (EC) adhesions in inflammation cascade ...
Debin Mao, Shouqin Lü, Ning Li, Yan Zhang, Mian Long   +4 more
doaj   +1 more source

Maize Anther Development Involves Translated Open Reading Frames From 3′ Untranslated Regions

Advanced Science, Volume 13, Issue 23, 23 April 2026.
This study examined the translation activity across ten stages of maize anther development, integrating transcriptome and small‐peptide data. It linked mutations in translated 3' ORFs to anther sterility, exemplified by Zm00001eb417050_3' ORF (known as APV1). In addition, the data indicated that maize anthers could assimilate CO2 through the stomata in
Chunyu Wang, Yuechao Wu, Shunxi Wang, Han Liu, Siqi Jiang, Yingjia Han, Liuji Wu, Tao Zhang, Mei Zhang   +8 more
wiley   +1 more source

Increased risk for T cell autoreactivity to ß-cell antigens in the mice expressing the Avy obesity-associated gene. [PDF]

, 2019
There has been considerable debate as to whether obesity can act as an accelerator of type 1 diabetes (T1D). We assessed this possibility using transgenic mice (MIP-TF mice) whose ß-cells express enhanced green fluorescent protein (EGFP). Infecting these
Atkinson, Mark A, Dang, Hoa, Kaufman, Daniel L, Sun, Ren, Tian, Jide, Wu, Ting-Ting, Yong, Jing   +6 more
core   +2 more sources

Age‐Like Methylation Changes of HSCs in GADD45B Knockout Mice Define Methylation Sites Associated With Loss of Function

Aging Cell, Volume 25, Issue 4, April 2026.
GADD45B knockout in hematopoietic stem cells causes DNA methylation changes that mirror some age‐associated patterns but don't affect HSC function or gene expression. We created a searchable database to identify consistently reported methylation sites associated with age‐related HSC functional decline.
Wakako Kuribayashi, Mayuri Tanaka‐Yano, Bongsoo Park, Hagai Yanai, Ferda Tekin‐Turhan, Isabel Beerman   +5 more
wiley   +1 more source