Results 81 to 90 of about 5,596 (181)

Age‐Like Methylation Changes of HSCs in GADD45B Knockout Mice Define Methylation Sites Associated With Loss of Function

Aging Cell, Volume 25, Issue 4, April 2026.
GADD45B knockout in hematopoietic stem cells causes DNA methylation changes that mirror some age‐associated patterns but don't affect HSC function or gene expression. We created a searchable database to identify consistently reported methylation sites associated with age‐related HSC functional decline.
Wakako Kuribayashi, Mayuri Tanaka‐Yano, Bongsoo Park, Hagai Yanai, Ferda Tekin‐Turhan, Isabel Beerman   +5 more
wiley   +1 more source

Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Nature Communications, 2017
The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may ...
Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow, Daniel I. Simon   +13 more
doaj   +1 more source

Exercise affects systemic basophil responses in humans: Applying an automated and modified basophil activation test (mBAT) in a field study

Cytometry Part B: Clinical Cytometry, Volume 110, Issue 2, Page 92-101, March 2026.
Abstract Basophils are effector cells in type I hypersensitivity reactions. Upon cross‐linking of surface‐bound (allergen‐specific) IgE, basophils release a variety of mediators. Determining the activation of basophils ex vivo with anti‐IgE (a basophil activation test or BAT) can be achieved using flow cytometry.
T. C. Pelgrim, B. N. Jukema, L. Koopmans, C. C. W. G. Bongers, M. T. E. Hopman, E. F. Knol, N. Vrisekoop, L. Koenderman   +7 more
wiley   +1 more source

Additional file 1 of Integrin Mac1 mediates paraquat and maneb-induced learning and memory impairments in mice through NADPH oxidase–NLRP3 inflammasome axis-dependent microglial activation

, 2023
Additional file 1: Fig. S1. P + M exposure elevates Mac1 expression in cortex of mice. The representative images of Mac1 staining in the cortex of mice at the indicated timepoints of P + M injection and quantification of Mac1 immunostaining density.
Liyan Hou (9944279), Zhengzheng Ruan (9944282), Jie Zhao (49409), Ruixue Huang (4227391), Qingshan Wang (3437543), Fuqiang Sun (12965597), Rui Chang (190622), Ying Wang (11406), Jianing Liu (140090)   +8 more
core   +1 more source

CellOntologyMapper: Consensus mapping of cell type annotation

iMetaOmics, Volume 3, Issue 1, March 2026.
CellOntologyMapper automates the standardization of cell type annotations in single‐cell RNA‐seq by mapping user‐defined names to the Cell Ontology (CL) and Cell Taxonomy (CT). The framework constructs a comprehensive embedding database of 19,381 curated cell types using sentence transformers, large language models, and synonym expansion.
Zehua Zeng, Xuehai Wang, Hongwu Du, Cencan Xing   +3 more
wiley   +1 more source

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

Functional Analysis of Macrophages in the Progression of Liver Cirrhosis and Liver Cancer [PDF]

Zhongguo quanke yixue
Background Hepatic macrophages play a vital role in the defense mechanisms and maintaining the internal environment stability of body, and are also major cellular components involved in liver injury and repair. Macrophages derived from hematopoietic stem
REN Lingxuan, LU Ziqi, QI Wei, FENG Zhijie
doaj   +1 more source

Practical Indices for Minimizing External Carbon Demand in Mainstream ANAMMOX: A Sensitivity‐ and Regression‐Based Approach

Water Environment Research, Volume 98, Issue 2, February 2026.
This study quantitatively assessed the external carbon demand of the mainstream ANAMMOX process in comparison with A2O and PD/A processes. The results demonstrated that mainstream ANAMMOX reduced external carbon requirements by up to 72.2% (vs. A2O) and 41.2% (vs. PD/A).
Sungryul Kim, Kyungik Gil
wiley   +1 more source

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, Volume 301, Issue 2, Page 222-240, February 2026.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source

12‐HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, Volume 13, Issue 5, 27 January 2026.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source