Results 81 to 90 of about 10,490 (182)

Targeting DESI2 as a Novel Therapeutic Strategy for JAK2‐Mutant Leukemias

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Mass spectrometry‐based proteomics identify DESI2 as a novel component of the JAK2‐V617F complex, which associates with and stabilizes mutant JAK2 through deSUMOylation and deubiquitination, therefore promoting JAK2 mutant cell growth and MPN disease onset in vivo.
Husheng Mei, Wuqiang Wen, Wenjun Zhang, Shujing Zhang, Ting Sun, Guiming Li, Jing Zhang, Shuang Qi, Jie Zhou, Bing Li, Yunshuo Zhao, Xiaotong Chen, Bowen Li, Yiying Xue, Wang Lu, Yanli Sun, Jingyao Wang, Hengyue Shan, Shengzhe Zhang, Yushan Huang, Yisa Chen, Wenchao Wang, Qingsong Liu, Wenchao Lu, Li Tan, Yi Ding, Jianfei Fu, Jun Long, Lei Zhang, Baobing Zhao, Aibin Liang, Baishan Jiang, Jing Yang   +32 more
wiley   +1 more source

A Program Logic for Verifying Secure Routing Protocols [PDF]

, 2014
The Internet, as it stands today, is highly vulnerable to attacks. However, little has been done to understand and verify the formal security guarantees of proposed secure inter-domain routing protocols, such as Secure BGP (S-BGP).
Chen, Chen, Jia, Limin, Loo, Boon Thau, Luo, Cheng, Xu, Hao, Zhou, Wenchao   +5 more
core   +5 more sources

Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Nature Communications, 2017
The binding of the leukocyte integrin Mac1 to the platelet receptor GPIbα is important for the physiological response to tissue injury. Here the authors show that this interaction also regulates thrombosis, without influencing bleeding time, which may ...
Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow, Daniel I. Simon   +13 more
doaj   +1 more source

Practical Indices for Minimizing External Carbon Demand in Mainstream ANAMMOX: A Sensitivity‐ and Regression‐Based Approach

Water Environment Research, Volume 98, Issue 2, February 2026.
This study quantitatively assessed the external carbon demand of the mainstream ANAMMOX process in comparison with A2O and PD/A processes. The results demonstrated that mainstream ANAMMOX reduced external carbon requirements by up to 72.2% (vs. A2O) and 41.2% (vs. PD/A).
Sungryul Kim, Kyungik Gil
wiley   +1 more source

Ultrastructural expansion microscopy reveals unexpected levels of glycosome heterogeneity in African trypanosomes

Journal of Microscopy, Volume 301, Issue 2, Page 222-240, February 2026.
Abstract Kinetoplastid parasites include several species. Trypanosoma brucei causes African sleeping sickness in humans and a wasting disease nagana in livestock. Trypanosoma cruzi is the causative agent of Chagas disease and Leishmania species cause leishmaniasis, which can present with visceral, cutaneous, or mucocutaneous symptoms.
Heidi Anderson, Rhonda Reigers Powell, Meredith Teilhet Morris   +2 more
wiley   +1 more source

12‐HETE is an Endogenous Modulator of BLT2 Triggering Vascular Degeneration, Dissection, and Rupture

Advanced Science, Volume 13, Issue 5, 27 January 2026.
In thoracic aortic dissection (TAD), elevated levels of the arachidonic acid metabolite 12‐HETE, produced by macrophage‐specific 12/15‐lipoxygenase (12/15‐LOX), bind to the BLT2 receptor on vascular cells. This activates the NOX‐1/ROS/NF‐κB signaling pathway, leading to IL‐6 release.
Yuyu Li, Jiaqi Yu, Weiyao Chen, Xue Wang, Xin Tan, Jing Cui, Yihao Wang, Xuan Xu, Rui Lin, Zhengkai Wang, Wenxi Jiang, Yongliang Zhong, Jie Du, Yuan Wang   +13 more
wiley   +1 more source

Functional Analysis of Macrophages in the Progression of Liver Cirrhosis and Liver Cancer [PDF]

Zhongguo quanke yixue
Background Hepatic macrophages play a vital role in the defense mechanisms and maintaining the internal environment stability of body, and are also major cellular components involved in liver injury and repair. Macrophages derived from hematopoietic stem
REN Lingxuan, LU Ziqi, QI Wei, FENG Zhijie
doaj   +1 more source

Phosphoinositide 3-OH Kinase Regulates Integrin-Dependent Processes in Neutrophils by Signaling through Its Effector ARAP3 [PDF]

, 2013
ARAP3, a GTPase activating protein for Rho and Arf family GTPases, is one of many phosphoinositide 3-OH kinase (PI3K) effectors. In this study, we investigate the regulatory input of PI3K upstream of ARAP3 by analyzing neutrophils from an ARAP3 ...
Attila Mócsai, Karen E. Anderson, Laure Gambardella, Len Stephens, Miklós Kovács, Phillip T. Hawkins, Sonja Vermeren, Susann Voigt, Zhou, Zoltán Jakus   +9 more
core   +1 more source

Rps19R67∆ mutation creates a model of Diamond–Blackfan anemia and reveals downstream mediators of p53 pathway

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Diamond–Blackfan anemia (DBA) is a rare bone marrow failure syndrome accompanied by cardiovascular, skeletal, and urogenital abnormalities. Most of the affected individuals carry mutations in ribosomal proteins, including RPS19, a component of the 40S ribosomal subunit.
Juraj Kokavec, Tereza Turková, Björn Schuster, Jan Prochazka, František Spoutil, Kristína Jamrichová, Markéta Holečková, Karel Chalupský, Inken M. Beck, Jesús Ruberte, Matilde Vale, Lukáš Čermák, Tomáš Stopka, Radislav Sedlacek   +13 more
wiley   +1 more source

Regulator of G‐Protein Signalling Protein AaRgs2 Negatively Regulates Appressorium‐Like Formation of Alternaria alternata Induced by Pear Cutin Monomer via the AaRgs2‐AaGα1‐AaAC Module

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
AaRgs2 negatively regulates appressorium‐like formation of A. alternata induced by pear cutin monomer via the AaRgs2‐AaGα1‐AaAC module. ABSTRACT Pathogenic fungi have developed complex and specific infection strategies to invade host tissues successfully.
Miao Zhang, Yuanping Nan, Yongcai Li, Yang Bi, Dov B. Prusky   +4 more
wiley   +1 more source