Results 81 to 90 of about 5,202 (155)

LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II

Experimental and Molecular Medicine, 2019
Immune response: White blood cells follow the leader In response to infection or tissue damage, white blood cells known as leukocytes exit blood vessels at specific sites, “hotspots.” Many leukocytes follow each other out through the same hotspot.
Young-Min Hyun, Young Ho Choe, Sang A. Park, Minsoo Kim   +3 more
doaj   +1 more source

Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.

PLoS ONE, 2011
Fbxo7 is an unusual F box protein that augments D-type cyclin complex formation with Cdk6, but not Cdk4 or Cdk2, and its over-expression has been demonstrated to transform immortalised fibroblasts in a Cdk6-dependent manner.
Mikhail Lomonosov, El Kahina Meziane, Hongtao Ye, David E Nelson, Suzanne J Randle, Heike Laman   +5 more
doaj   +1 more source

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation

The EMBO Journal
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Kang Zhu, Evgeniia Prokhorova, Nicolas Bigot, Domagoj Baretić, Juraj Ahel, Jonas Damgaard Elsborg, Michael L Nielsen, Tim Clausen, Sébastien Huet, Mario Niepel, Sumana Sanyal, Dragana Ahel, Rebecca Smith, Ivan Ahel   +18 more
doaj   +1 more source

Comprehensive analysis of the mitochondrial genome of Rehmannia glutinosa: insights into repeat-mediated recombinations and RNA editing-induced stop codon acquisition

Frontiers in Plant Science
Rehmannia glutinosa is an economically significant medicinal plant. Yet, the structure and sequence of its mitochondrial genome has not been published, which plays a crucial role in evolutionary analysis and regulating respiratory-related macromolecule ...
Tiexin Zeng, Yang Ni, Jingling Li, Haimei Chen, Qianqi Lu, Mei Jiang, Lijia Xu, Chang Liu, Peigen Xiao   +8 more
doaj   +1 more source

3005 Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of leukocytes has received considerably less attention.
Gautam Sule, William J. Kelley, Srilakshmi Yalavarthi, Omolola Eniola-Adefeso, Jason S. Knight   +4 more
doaj   +1 more source

Correction: Corrigendum: Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Nature Communications, 2017
Nature Communications 8: Article number:15559 (2017); Published 30 May 2017; Updated 4 July 2017 The original version of this Article contained an error in the email address of the corresponding author Daniel I. Simon.
Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow, Daniel I. Simon   +13 more
doaj   +1 more source

The Opioid Peptide Dynorphin a Induces Leukocyte Responses via Integrin Mac-1 (αβ, CD11b/CD18)

Molecular Pain, 2015
Background Opioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation and cytokine production. The mechanisms
Nataly P. Podolnikova, Julie A. Brothwell, Tatiana P. Ugarova   +2 more
doaj   +1 more source

Structural Determinants of Mac1 Inhibition: Lessons from Ligand Binding Patterns

This study comprehensively analyzes how various inhibitors bind to the SARS-CoV-2 macrodomain Mac1, a key protein implicated in hampering the host's immune response following viral infection. In this study we used volume-based metadynamics simulations to investigate the binding mechanisms of ADP-ribose and two Mac1 inhibitors: the adenineanalogue GS ...
Weber, Verena, Rossetti, Giulia, Lüscher, Bernhard, Korn, Patricia, Knapp, Sarah   +4 more
openaire   +1 more source

SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes

Experimental and Molecular Medicine, 2019
Atherosclerosis: Intervening in the early stages of plaque formation Researchers have identified a possible new tool, the signaling molecule SIRT1, to fight vascular diseases such as atherosclerosis, hardening of the arteries.
Seung Jin Lee, Seung Eun Baek, Min A. Jang, Chi Dae Kim   +3 more
doaj   +1 more source

HTRF-based assay for detection of mono-ADP-ribosyl hydrolyzing macrodomains and inhibitor screening

iScience
Summary: The COVID-19 pandemic has highlighted the lack of effective, ready-to-use antivirals for the treatment of viruses with pandemic potential. The development of a diverse drug portfolio is therefore crucial for pandemic preparedness.
Niklas Ildefeld, Dieter Steinhilber, Ewgenij Proschak, Jan Heering   +3 more
doaj   +1 more source