Results 101 to 110 of about 5,596 (181)

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation

The EMBO Journal
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Kang Zhu, Evgeniia Prokhorova, Nicolas Bigot, Domagoj Baretić, Juraj Ahel, Jonas Damgaard Elsborg, Michael L Nielsen, Tim Clausen, Sébastien Huet, Mario Niepel, Sumana Sanyal, Dragana Ahel, Rebecca Smith, Ivan Ahel   +18 more
doaj   +1 more source

Comprehensive analysis of the mitochondrial genome of Rehmannia glutinosa: insights into repeat-mediated recombinations and RNA editing-induced stop codon acquisition

Frontiers in Plant Science
Rehmannia glutinosa is an economically significant medicinal plant. Yet, the structure and sequence of its mitochondrial genome has not been published, which plays a crucial role in evolutionary analysis and regulating respiratory-related macromolecule ...
Tiexin Zeng, Yang Ni, Jingling Li, Haimei Chen, Qianqi Lu, Mei Jiang, Lijia Xu, Chang Liu, Peigen Xiao   +8 more
doaj   +1 more source

3005 Integrin Mac-1 Potentiates Neutrophil Adhesion and NET Release in Antiphospholipid Syndrome

Journal of Clinical and Translational Science, 2019
OBJECTIVES/SPECIFIC AIMS: While the role of antiphospholipid antibodies in activating endothelial cells has been extensively studied, the impact of these antibodies on the adhesive potential of leukocytes has received considerably less attention.
Gautam Sule, William J. Kelley, Srilakshmi Yalavarthi, Omolola Eniola-Adefeso, Jason S. Knight   +4 more
doaj   +1 more source

Correction: Corrigendum: Leukocyte integrin Mac-1 regulates thrombosis via interaction with platelet GPIbα

Nature Communications, 2017
Nature Communications 8: Article number:15559 (2017); Published 30 May 2017; Updated 4 July 2017 The original version of this Article contained an error in the email address of the corresponding author Daniel I. Simon.
Yunmei Wang, Huiyun Gao, Can Shi, Paul W. Erhardt, Alexander Pavlovsky, Dmitry A. Soloviev, Kamila Bledzka, Valentin Ustinov, Liang Zhu, Jun Qin, Adam D. Munday, Jose Lopez, Edward Plow, Daniel I. Simon   +13 more
doaj   +1 more source

The copper-sensing transcription factor Mac1, the histone deacetylase Hst1, and nicotinic acid regulate de novo NAD+ biosynthesis in budding yeast [PDF]

, 2019
NADH (NAD+) is an essential metabolite involved in various cellular biochemical processes. The regulation of NAD+ metabolism is incompletely understood.
Groth, Benjamin, Cater, Timothy, Lin, Su-Ju, Dhugga, Gagandeep, James Theoga Raj, Christol, Croft, Trevor, Venkatakrishnan, Padmaja   +6 more
core   +1 more source

The Opioid Peptide Dynorphin a Induces Leukocyte Responses via Integrin Mac-1 (αβ, CD11b/CD18)

Molecular Pain, 2015
Background Opioid peptides, including dynorphin A, besides their analgesic action in the nervous system, exert a broad spectrum of effects on cells of the immune system, including leukocyte migration, degranulation and cytokine production. The mechanisms
Nataly P. Podolnikova, Julie A. Brothwell, Tatiana P. Ugarova   +2 more
doaj   +1 more source

CD244 maintains the proliferation ability of leukemia initiating cells through SHP-2/p27kip1 signaling

Haematologica, 2017
Targeting leukemia initiating cells is considered to be an effective way to cure leukemia, for which it is critical to identify novel therapeutic targets.
Feifei Zhang, Xiaoye Liu, Chiqi Chen, Jun Zhu, Zhuo Yu, Jingjing Xie, Li Xie, Haitao Bai, Yaping Zhang, Xia Fang, Hao Gu, Chun Wang, Wei Weng, Cheng Cheng Zhang, Guo-Qiang Chen, Aibing Liang, Junke Zheng   +16 more
doaj   +1 more source

Different Calcium and Src Family Kinase Signaling in Mac-1 Dependent Phagocytosis and Extracellular Vesicle Generation

Frontiers in Immunology, 2019
Encountering opsonized particles by neutrophils results in phagocytosis of the particle and generation of extracellular vesicles with antibacterial property (aEV).
Ákos M. Lőrincz, Viktória Szeifert, Balázs Bartos, Dávid Szombath, Attila Mócsai, Erzsébet Ligeti   +5 more
doaj   +1 more source

Structural Determinants of Mac1 Inhibition: Lessons from Ligand Binding Patterns

This dataset accompanies the study "Structural Determinants of Mac1 Inhibition: Lessons from Ligand Binding Patterns" and contains the computational and structural data used to investigate ligand recognition and inhibition mechanisms of the SARS-CoV-2 Macrodomain Mac1.
Weber, Verena, Rossetti, Giulia, Lüscher, Bernhard, Korn, Patricia, Knapp, Sarah   +4 more
openaire   +3 more sources

SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes

Experimental and Molecular Medicine, 2019
Atherosclerosis: Intervening in the early stages of plaque formation Researchers have identified a possible new tool, the signaling molecule SIRT1, to fight vascular diseases such as atherosclerosis, hardening of the arteries.
Seung Jin Lee, Seung Eun Baek, Min A. Jang, Chi Dae Kim   +3 more
doaj   +1 more source