Results 111 to 120 of about 5,596 (181)

HTRF-based assay for detection of mono-ADP-ribosyl hydrolyzing macrodomains and inhibitor screening

iScience
Summary: The COVID-19 pandemic has highlighted the lack of effective, ready-to-use antivirals for the treatment of viruses with pandemic potential. The development of a diverse drug portfolio is therefore crucial for pandemic preparedness.
Niklas Ildefeld, Dieter Steinhilber, Ewgenij Proschak, Jan Heering   +3 more
doaj   +1 more source

Study of metalloregulated transcription in Saccharomyces serevisiae: purification of new polyprotein complexes - New role of Rad9 cell cycle checkpoint protein in Mac1-regulated transcription

, 2007
In Saccharomyces cerevisiae, Mac1 is a copper-regulated. Mac1 recognizes and binds to specific DNA sequences and activates genes involved in copper uptake (CTR1, CTR3, FRE1, FRE7).
Γκούσκου, Καλλιόπη, Gkouskou, Kalliopi   +1 more
core   +1 more source

Assays for the interaction of CAP1 with MAC1 and its function in yeast.

, 2012
A. The domain structure of M. oryzae Cap1, S. cerevisiae Srv2, and human Cap1(hCap1). ACB, AC-binding domain; P1 and P2, proline-rich regions; AB; actin-binding domain. B.
Brian Shaw (137543), Haifeng Zhang (137541), Jin-Rong Xu (119406), Guotian Li (137542), Xiaoying Zhou (119401)   +4 more
core   +1 more source

The role of MAC1 in diesel exhaust particle-induced microglial activation and loss of dopaminergic neuron function

, 2013
Increasing reports support that air pollution causes neuroinflammation and is linked to central nervous system (CNS) disease/damage. Diesel exhaust particles (DEP) are a major component of urban air pollution, which has been linked to microglial ...
Levesque, Shannon, Lull, Melinda E., Michelle L. Block, Shannon Levesque, Thomas Taetzsch, Jo Anne Johnson, Block, Michelle L., Constance McGraw, Melinda E. Lull, Taetzsch, Thomas, McGraw, Constance, Johnson, Jo Anne   +11 more
core   +1 more source

The role of MAC1 in copper tolerance of Saccharomyces cerevisiae nonsense-mediated mRNA decay mutants

, 2013
The nonsense-mediated mRNA (NMD) pathway, present in most eukaryotic cells is a specialized pathway that leads to the recognition and rapid degradation of mRNAs with premature termination codons and some natural mRNAs.
O'Connell, Danielle, O'Connell, Danielle.   +1 more
core  

A differential genome-wide transcriptome analysis : impact of cellular copper on complex biological processes like aging and development

, 2012
The regulation of cellular copper homeostasis is crucial in biology. Impairments lead to severe dysfunctions and are known to affect aging and development.
Servos, Jörg, Hamann, Andrea, Andrea Hamann, Jörg Servos, Heinz D. Osiewacz (120841), Osiewacz, Heinz D., Andrea Hamann (120836), Carolin Grimm (120839), Grimm, Carolin, Jörg Servos (120834), Heinz D Osiewacz, Carolin Grimm   +11 more
core   +1 more source

DC development in bone marrow cultures.

, 2012
(A) Representative FACS plots of WT and Pin1-null bone marrow-derived Mac1- cDC generated by culturing with FL. Cells were previously gated as B220-Mac1− (“Mac1−”) and cDC are identified as MHCIIhiCD11chi cells.
Theresa J. Barberi (189449), Alexis Dunkle (189451), Luigi Racioppi (104562), Anthony R. Means (189453), You-Wen He (179462)   +4 more
core   +1 more source

Study of metalloregulated transcription in Saccharomyces cerevisiae: Purification of new polyprotein complexes – New role of Rad9 cell cycle checkpoint protein in Mac1-regulated transcription [PDF]

, 2008
Ο Mac1 αποτελεί χαλκορυθμιζόμενο, μεταγραφικό παράγοντα του Saccharomyces cerevisiae. Προσδένεται σε ειδικές αλληλουχίες DNA και ρυθμίζει γονίδια (π.χ. CTR1, CTR3, FRE1, FRE7), οι πρωτεΐνες των οποίων είναι υπεύθυνες για την είσοδο του χαλκού στο κύτταρο.
Γκούσκου, Καλλιόπη
core  

Synthesis and Biological Evaluation of Modified Peptide Derivatives Targeting the SARS-CoV‑2 Nsp3 Macrodomain (Mac1) Replication Domain. [PDF]

ACS Omega
Özmen Ö, Oruçoğlu B, Dingiş Birgül Sİ, Öztürk Civelek D, Gül Ş, Akdemir A, Sönmez F, Zengin Kurt B.   +7 more
europepmc   +1 more source

Cross-species transcriptomic integration reveals a MIRO1-mediated macrophage-T cell axis in glioma. [PDF]

Life Sci Alliance
Du Z, Li M, Bergsneider BH, Tsai AP, Cho KB, Kim LH, Choi J, Li G, Wyss-Coray T, Lim M, Wang X.   +10 more
europepmc   +1 more source