Results 111 to 120 of about 10,490 (182)

Different Calcium and Src Family Kinase Signaling in Mac-1 Dependent Phagocytosis and Extracellular Vesicle Generation

Frontiers in Immunology, 2019
Encountering opsonized particles by neutrophils results in phagocytosis of the particle and generation of extracellular vesicles with antibacterial property (aEV).
Ákos M. Lőrincz, Viktória Szeifert, Balázs Bartos, Dávid Szombath, Attila Mócsai, Erzsébet Ligeti   +5 more
doaj   +1 more source

SIRT1 inhibits monocyte adhesion to the vascular endothelium by suppressing Mac-1 expression on monocytes

Experimental and Molecular Medicine, 2019
Atherosclerosis: Intervening in the early stages of plaque formation Researchers have identified a possible new tool, the signaling molecule SIRT1, to fight vascular diseases such as atherosclerosis, hardening of the arteries.
Seung Jin Lee, Seung Eun Baek, Min A. Jang, Chi Dae Kim   +3 more
doaj   +1 more source

The Role of Hypothalamic Inflammation in Dim Light at Night and High Fat Diet Induced Metabolic Disturbance [PDF]

, 2013
The prevalence of obesity and metabolic disorders is rapidly increasing worldwide. This increase in metabolic dysfunction correlates with increased exposure to artificial light at night (LAN).
Lieberman, Rebecca
core  

HTRF-based assay for detection of mono-ADP-ribosyl hydrolyzing macrodomains and inhibitor screening

iScience
Summary: The COVID-19 pandemic has highlighted the lack of effective, ready-to-use antivirals for the treatment of viruses with pandemic potential. The development of a diverse drug portfolio is therefore crucial for pandemic preparedness.
Niklas Ildefeld, Dieter Steinhilber, Ewgenij Proschak, Jan Heering   +3 more
doaj   +1 more source

Efficient Binding Affinity Estimation for Fragment-Based Compounds Using a Separated Topologies Approach. [PDF]

J Chem Inf Model
Caldaruse AM, Baumann HM, Mobley DL.
europepmc   +1 more source

Evolution of distinct subclones in a CALM-AF10-driven AML murine model results in leukemias with different phenotypes. [PDF]

Blood Neoplasia
Zandvakili N, Lee HM, Desai RH, Oryshchuk A, Browett PJ, Kakadia PM, Bohlander SK.   +6 more
europepmc   +1 more source

Rewriting the viral script: post-translational modifications orchestrating SARS-CoV-2 pathogenesis and immune evasion. [PDF]

Front Microbiol
Qu J, Liu M, Zhou C.
europepmc   +1 more source

Single-nucleotide human disease mutation inactivates a blood-regenerative GATA2 enhancer [PDF]

, 2019
Bresnick, Emery H, Cao, Miao, Choi, Kyunghee, Hofmann, Inga, Johnson, Kirby D, Keles, Sunduz, Liu, Peng, Mahta, Charu, Soukup, Alexandra A, Wu, Jun, Zhang, Jing, Zheng, Ye, Zhou, Yun   +12 more
core   +1 more source

Discovery of AVI-6451, a Potent and Selective Inhibitor of the SARS-CoV-2 ADP-Ribosylhydrolase Mac1 with Oral Efficacy In Vivo. [PDF]

J Med Chem
Jaishankar P, Correy GJ, Matsui Y, Togo T, Rachman MM, Stevens MGV, Hantz ER, Zheng J, Diolaiti ME, Montano M, Taha TY, Rosecrans J, Pampel J, Krogan NJ, Shoichet BK, Ashworth A, Ott M, Fraser JS, Renslo AR.   +18 more
europepmc   +1 more source

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2. [PDF]

J Chem Inf Model
Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M.   +82 more
europepmc   +1 more source