Results 91 to 100 of about 5,596 (181)

A proposed model for the antioxidative mechanism through Mac1 activated by NO.

, 2014
When yeast cells are exposed to high-temperature stress, NO is produced from arginine by NOS-like activity. NO-mediated Mac1 activation through its post-translational modification upregulates the expression of CTR1, which encodes a copper transporter ...
Hiroshi Takagi (271173), Akira Nishimura (665814), Miho Aitoku (665812), Yu Sasano (665815), Yuki Manago (665813), Ryo Nasuno (665811)   +5 more
core   +1 more source

Rps19R67∆ mutation creates a model of Diamond–Blackfan anemia and reveals downstream mediators of p53 pathway

HemaSphere, Volume 10, Issue 1, January 2026.
Abstract Diamond–Blackfan anemia (DBA) is a rare bone marrow failure syndrome accompanied by cardiovascular, skeletal, and urogenital abnormalities. Most of the affected individuals carry mutations in ribosomal proteins, including RPS19, a component of the 40S ribosomal subunit.
Juraj Kokavec, Tereza Turková, Björn Schuster, Jan Prochazka, František Spoutil, Kristína Jamrichová, Markéta Holečková, Karel Chalupský, Inken M. Beck, Jesús Ruberte, Matilde Vale, Lukáš Čermák, Tomáš Stopka, Radislav Sedlacek   +13 more
wiley   +1 more source

Λειτουργική συσχέτιση της πρωτεΐνης Rad9 με τον χαλκορυθμιζόμενο μεταγραφικό παράγοντα Mac1 στον Saccharomyces cerevisiae [PDF]

, 2003
In Saccharomyces cerevisiae, Mac1 is a copper-regulated DNA binding transcription factor that, under copper depletion conditions, activates genes involved in copper uptake (CTR1, CTR3, FRE1, FRE7). Previous evidence suggested that, in addition to copper,
Γκούσκου, Καλλιόπη, Gkouskou, Kalliopi   +1 more
core  

Regulator of G‐Protein Signalling Protein AaRgs2 Negatively Regulates Appressorium‐Like Formation of Alternaria alternata Induced by Pear Cutin Monomer via the AaRgs2‐AaGα1‐AaAC Module

Molecular Plant Pathology, Volume 27, Issue 1, January 2026.
AaRgs2 negatively regulates appressorium‐like formation of A. alternata induced by pear cutin monomer via the AaRgs2‐AaGα1‐AaAC module. ABSTRACT Pathogenic fungi have developed complex and specific infection strategies to invade host tissues successfully.
Miao Zhang, Yuanping Nan, Yongcai Li, Yang Bi, Dov B. Prusky   +4 more
wiley   +1 more source

Talin and kindlin : batman and robin of Mac1 integrin activation?

, 2009
Macrophage 1 (Mac1) integrin is a leukocyte-restricted adhesion molecule highly expressed on phagocytes and is essential in the development of immune responses. In a normal physiological condition, activation of Mac1 is initiated via inside-out signaling.
Henni Djunaidi.
core  

Discovery of 2‑Amide-3-methylester Thiophenes that Target SARS-CoV‑2 Mac1 and Repress Coronavirus Replication, Validating Mac1 as an Antiviral Target

The COVID-19 pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus has made it clear that further development of antiviral therapies will be needed.
Men Thi Hoai Duong (18332620), Juha P. Heiskanen (1432789), Sven T. Sowa (9017705), Anthony R. Fehr (11835136), Sarah Wazir (8970386), Jessica J. Pfannenstiel (18332617), Dana Ferraris (1523554), Tomi A. O. Parviainen (14424871), Albert Galera-Prat (161919), Mirko M. Maksimainen (8486286), Daniel Cluff (18332623), Lari Lehtiö (1860307)   +11 more
core   +2 more sources

Detection of Dysplastic Intestinal Adenomas Using a Fluorescent Folate Imaging Probe

Molecular Imaging, 2005
Macrophages have long been recognized as a prominent component of tumors. Activated macrophages overexpress folate receptors and we used this phenomenon to image inflammatory reactions in colon dysplasia using a fluorescent folate probe (FFP).
Wei-Tsung Chen, Khashayarsha Khazaie, Guoying Zhang, Ralph Weissleder, Ching-Hsuan Tung   +4 more
doaj   +1 more source

LFA-1 (CD11a/CD18) and Mac-1 (CD11b/CD18) distinctly regulate neutrophil extravasation through hotspots I and II

Experimental and Molecular Medicine, 2019
Immune response: White blood cells follow the leader In response to infection or tissue damage, white blood cells known as leukocytes exit blood vessels at specific sites, “hotspots.” Many leukocytes follow each other out through the same hotspot.
Young-Min Hyun, Young Ho Choe, Sang A. Park, Minsoo Kim   +3 more
doaj   +1 more source

Expression of Fbxo7 in haematopoietic progenitor cells cooperates with p53 loss to promote lymphomagenesis.

PLoS ONE, 2011
Fbxo7 is an unusual F box protein that augments D-type cyclin complex formation with Cdk6, but not Cdk4 or Cdk2, and its over-expression has been demonstrated to transform immortalised fibroblasts in a Cdk6-dependent manner.
Mikhail Lomonosov, El Kahina Meziane, Hongtao Ye, David E Nelson, Suzanne J Randle, Heike Laman   +5 more
doaj   +1 more source

MAC1, a nuclear regulatory protein related to Cu-dependent transcription factors is involved in Cu/Fe utilization and stress resistance in yeast

, 1993
The related transcription factors ACE1 of Saccharomyces cerevisiae and AMT1 of Candida glabrata are involved in copper metabolism by activating the transcription of copper metallothionein genes. ACE1 and AMT1 are 'copper-fist' transcription factors which
Lee, J., Romeo, A., Hassett, R., Jentsch, S., Jungmann, J., Reins, H., Kosman, D.   +6 more
core   +1 more source