Results 31 to 40 of about 5,202 (155)
Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3 [PDF]
Biochemistry, 2020 The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the RNA-dependent RNA polymerase, helicase, and main protease, are well conserved between SARS-CoV-2 and the original SARS virus, but several others are not. This study examines one
Frick, David N. +4 more
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Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
IUCrJ, 2020 Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska +6 more
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HMGB1 Acts on Microglia Mac1 to Mediate Chronic Neuroinflammation That Drives Progressive Neurodegeneration [PDF]
The Journal of Neuroscience, 2011 What drives the gradual degeneration of dopamine neurons in Parkinson's disease (PD), the second most common neurodegenerative disease, remains elusive. Here, we demonstrated, for the first time, that persistent neuroinflammation was indispensible for such a neurodegenerative process. 1-Methyl-4-phenylpyridinium, lipopolysaccharide
Hui-Ming, Gao +5 more
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Fluid shear-induced cathepsin B release in the control of Mac1-dependent neutrophil adhesion [PDF]
Journal of Leukocyte Biology, 2017 Abstract There is compelling evidence that circulatory hemodynamics prevent neutrophil activation, including adhesion to microvessels, in the microcirculation. However, the underlying mechanism or mechanisms by which that mechanoregulation occurs remain unresolved.
Akenhead, Michael L +3 more
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Discovery of compounds that inhibit SARS-CoV-2 Mac1-ADP-ribose binding by high-throughput screening [PDF]
Antiviral Research, 2022 ABSTRACT The emergence of several zoonotic viruses in the last twenty years, especially the pandemic outbreak of SARS-CoV-2, has exposed a dearth of antiviral drug therapies for viruses with pandemic potential.
Anu Roy +9 more
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mSphere, 2019 Copper (Cu) is an essential trace element in all organisms, and Cu acquisition during periods of starvation is important for cell survival and proliferation.
Zhendong Cai +4 more
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The Development and creation of a software system for the monitoring system MAC1
International Journal of Mathematics and Physics, 2019 Abstract. A special system of acoustic detectors was created to search for possible correlations between wide air showers and the signal of elastic oscillations from the depths of the earth's crust. They are intended for joint synchronous work with storm installation.
B. A. Iskakov +4 more
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Molecular Neurobiology, 2023 AbstractRecent studies showed increased expression of complements in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. However, the mechanism regulating the expression of complements and their roles in the pathogenesis of neurodegeneration are unclear.
Ran Zhou +8 more
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Journal of Oral Microbiology, 2023 Candida albicans is a normal resident of the human oral cavity. It is also the most common fungal pathogen, causing various oral diseases, particularly in immunocompromised individuals.
Qian Jiang +4 more
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Results from the MAC1 Vertex Chamber [PDF]
, 1988 In the summer of 1983, the MAC and Mark-II collaborations gave evidence for bottom hadron lifetimes or 1–2 ps2 based on data accumulated at the PEP e + e − storage ring at SLAC. The importance and fundamental nature of this measurement3 prompted the MAC collaboration to propose, in autumn 1983, the addition of a high precision vertex chamber to the MAC
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