Results 31 to 40 of about 5,596 (181)
The Location of the Antimicrobial Peptide Maculatin 1.1 in Model Bacterial Membranes
Frontiers in Chemistry, 2020 Maculatin 1.1 (Mac1) is an antimicrobial peptide (AMP) from the skin secretions of Australian tree frogs. In this work, the interaction of Mac1 with anionic phospholipid bilayers was investigated by NMR, circular dichroism (CD) spectroscopy, neutron ...
Anton P. Le Brun +3 more
doaj +1 more source
Regulation of Copper Metabolism by Nitrogen Utilization in Saccharomyces cerevisiae
Journal of Fungi, 2021 To understand the relationship between carbon or nitrogen utilization and iron homeostasis, we performed an iron uptake assay with several deletion mutants with partial defects in carbon or nitrogen metabolism. Among them, some deletion mutants defective
Suzie Kang +3 more
doaj +1 more source
Mac1 N40A protein is less stable in cells than are Mac1 WT or Mac1 N40D proteins.
, 2023 Western blot analyses of cell lysates from A549 lung cancer cells lentivirally transduced with vectors expressing Strep-tagged Mac1 WT, Mac1 N40D or Mac1 N40A proteins. β-actin is shown as a loading control.
Rahul K. Suryawanshi (2856155) +16 more
core +1 more source
Journal of Virology, 2023 ABSTRACT ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD + to protein or nucleic acid substrates. This modification can be removed by several different types of proteins, including macrodomains.
Catherine M. Kerr +8 more
openaire +4 more sources
Absent regulation of iron acquisition by the copper regulator Mac1 in A. fumigatus
Biochemical Journal, 2020 Aspergillus fumigatus is the most common cause of invasive aspergillosis, a life-threatening infection mainly affecting immunocompromised patients. The essential metals copper and iron play crucial roles in virulence of this mold. Recently, the copper-regulatory transcription factor Mac1 was reported to additionally be involved in the control of iron ...
Annie Yap +2 more
openaire +2 more sources
Independent Metalloregulation of Ace1 and Mac1 in Saccharomyces cerevisiae
Eukaryotic Cell, 2005 ABSTRACT Ace1 and Mac1 undergo reciprocal copper metalloregulation in yeast cells. Mac1 is functional as a transcriptional activator in copper-deficient cells, whereas Ace1 is a transcriptional activator in copper-replete cells. Cells undergoing a transition from copper-deficient to copper-sufficient conditions through a switch in the growth ...
Greg, Keller +2 more
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Molecular Basis for ADP-Ribose Binding to the Mac1 Domain of SARS-CoV-2 nsp3 [PDF]
Biochemistry, 2020 The virus that causes COVID-19, SARS-CoV-2, has a large RNA genome that encodes numerous proteins that might be targets for antiviral drugs. Some of these proteins, such as the RNA-dependent RNA polymerase, helicase, and main protease, are well conserved between SARS-CoV-2 and the original SARS virus, but several others are not. This study examines one
Frick, David N. +4 more
openaire +3 more sources
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
IUCrJ, 2020 Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska +6 more
doaj +1 more source
Journal of Oral Microbiology, 2023 Candida albicans is a normal resident of the human oral cavity. It is also the most common fungal pathogen, causing various oral diseases, particularly in immunocompromised individuals.
Qian Jiang +4 more
doaj +1 more source
Molecular Neurobiology, 2023 AbstractRecent studies showed increased expression of complements in various neurodegenerative diseases, including Alzheimer’s and Parkinson’s diseases. However, the mechanism regulating the expression of complements and their roles in the pathogenesis of neurodegeneration are unclear.
Ran Zhou +8 more
openaire +2 more sources