Results 61 to 70 of about 1,793 (163)

Molecular Insights into Poly(ADP-ribose) Recognition and Processing

Biomolecules, 2012
Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel, Eva Barkauskaite, Roko Žaja, Andreja Mikoč   +3 more
doaj   +1 more source

CACHE Challenge #3: Targeting the Nsp3 Macrodomain of SARS-CoV-2. [PDF]

J Chem Inf Model
The third Critical Assessment of Computational Hit-finding Experiments (CACHE) challenged computational teams to identify chemically novel ligands targeting the macrodomain 1 of SARS-CoV-2 Nsp3, a promising coronavirus drug target. Twenty-three groups deployed diverse design strategies to collectively select 1739 ligand candidates.
Herasymenko O, Silva M, Correy GJ, Abu-Saleh AAA, Ackloo S, Arrowsmith C, Ashworth A, Ban F, Beck H, Bishop KP, Bohórquez HJ, Bolotokova A, Breznik M, Chau I, Chen Y, Cherkasov A, Dehaen W, Della Corte D, Denzinger K, Doering NP, Edfeldt K, Edwards A, Fayne D, Gentile F, Gibson E, Gokdemir O, Gunnarsson A, Günther J, Irwin JJ, Jensen JH, Harding RJ, Hillisch A, Hoffer L, Hogner A, Hutchinson A, Kandwal S, Karlova A, Koirala K, Kotelnikov S, Kozakov D, Lee J, Lee S, Lessel U, Liu S, Liu X, Loppnau P, Meiler J, Moretti R, Moroz YS, Muvva C, Oprea TI, Paige B, Pandit A, Park K, Poda G, Protopopov MV, Pütter V, Ravichandran R, Rognan D, Rosta E, Sabnis Y, Scott T, Seitova A, Sharma P, Sindt F, Song M, Steinmann C, Stevens R, Talagayev V, Tararina VV, Tarkhanova O, Tingey D, Trant JF, Treleaven D, Tropsha A, Walters P, Wells J, Westermaier Y, Wolber G, Wortmann L, Zheng S, Fraser JS, Schapira M.   +82 more
europepmc   +7 more sources

Recent advances in noncanonical inhibition mechanisms of anti‐CRISPR proteins

mLife, Volume 5, Issue 2, Page 133-147, April 2026.
Abstract The CRISPR‐Cas system constitutes an adaptive immune mechanism in prokaryotes that defends against mobile genetic elements. Within the perpetual co‐evolutionary arms race between bacteria and their viral predators, bacteriophages encode anti‐CRISPR (Acr) proteins that use sophisticated molecular strategies to sabotage CRISPR‐Cas function ...
Lingguang Yang, Rongjun Luo, Wei Zhou, Peipei Yin, Yue Feng, Yi Zhang   +5 more
wiley   +1 more source

Recombinant infectious bronchitis virus containing mutations in non-structural proteins 10, 14, 15, and 16 and within the macrodomain provides complete protection against homologous challenge

Journal of Virology
Infectious bronchitis virus (IBV) is the etiological agent of infectious bronchitis, an acute highly contagious economically important disease of chickens.
Sarah Keep, Katalin Foldes, Guilia Dowgier, Graham Freimanis, Chandana Tennakoon, Shafiyeel Chowdhury, Adam Rayment, James Kirk, Trinity Bakshi, Phoebe Stevenson-Leggett, Yana Chen, Paul Britton, Erica Bickerton   +12 more
doaj   +1 more source

Differential management of the replication terminus regions of the two Vibrio cholerae chromosomes during cell division. [PDF]

PLoS Genetics, 2014
The replication terminus region (Ter) of the unique chromosome of most bacteria locates at mid-cell at the time of cell division. In several species, this localization participates in the necessary coordination between chromosome segregation and cell ...
Gaëlle Demarre, Elisa Galli, Leila Muresan, Evelyne Paly, Ariane David, Christophe Possoz, François-Xavier Barre   +6 more
doaj   +1 more source

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA

Computational and Structural Biotechnology Journal, 2022
ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes.
Andrea Hloušek-Kasun, Petra Mikolčević, Johannes Gregor Matthias Rack, Callum Tromans-Coia, Marion Schuller, Gytis Jankevicius, Marija Matković, Branimir Bertoša, Ivan Ahel, Andreja Mikoč   +9 more
doaj   +1 more source

Prokaryotic defense systems: Diversity and evolutionary adaptation

mLife, Volume 5, Issue 1, Page 3-16, February 2026.
Abstract Bacteriophages and archaeal viruses are the most abundant biological entities on Earth. Through a long‐standing co‐evolutionary arms race, they have driven the emergence of a diverse repertoire of prokaryotic defense systems. This review summarizes these systems, highlighting their diverse antiviral mechanisms across distinct stages of viral ...
Changjialian Yang, Luyao Gong, Jing Guo, Hua Xiang   +3 more
wiley   +1 more source

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen, Qiao‐ling Huang, Ming‐zhi Han, Xue‐hui Hong, De‐yi Feng, Lu‐ming Yao, Wen‐bin Hong, Yue Chen, Ya‐ying Huang, Hang‐zi Chen, Qiao Wu   +10 more
wiley   +1 more source

Gene clusters reflecting macrodomain structure respond to nucleoid perturbations [PDF]

Molecular BioSystems, 2010
Abstract Focusing on the DNA-bridging nucleoidproteins Fis and H-NS, and integrating several independent experimental and bioinformatic data sources, we investigate the links between chromosomal spatial organization and global transcriptional regulation.
Scolari, Vittore F., Bassetti, Bruno, Sclavi, Bianca, Lagomarsino, Marco Cosentino   +3 more
openaire   +4 more sources

Ferroelectricity restoration via thermally driven recovery of surface damage layers in BiFeO3‐based lead‐free ceramics

Journal of the American Ceramic Society, Volume 109, Issue 1, January 2026.
In BiFeO3‐based lead‐free ceramics, ferroelectric polarization is suppressed by a polishing‐induced surface damage layer through the inhibition of Bi3⁺ off‐centering and nanoscale domain formation. Upon thermal annealing, the damaged layer is relaxed, Bi3⁺ displacement is restored, and nanoscale domains are reactivated, resulting in the recovery of the
Sangwook Kim, Hyunwook Nam, Hae In Choi
wiley   +1 more source