Results 81 to 90 of about 1,793 (163)

Vascular Immunotargeting to Endothelial Surface in a Specific Macrodomain in Alveolar Capillaries

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract A novel 85 kD glycoprotein (gp85) is a marker of the avesicular zone, a thin part of pulmonary endothelial cells separating alveolar and vascular compartments and lacking vesicles. This report presents the first evaluation whether mAb 30B3, a monoclonal antibody to gp85, can be used for targeting of drugs to the surface of ...
Murciano, Juan Carlos, Harshaw, David W., GHITESCU, LUCIAN, DANILOV, SERGEI M., Muzykantov, Vladimir R.   +4 more
openaire   +3 more sources

Re‐evaluation of PTEN as an ADP‐ribosylated tankyrase binding partner

The FEBS Journal, Volume 292, Issue 17, Page 4611-4630, September 2025.
We reveal that PTEN and its conserved putative tankyrase‐binding motif (pTBM) originated before tankyrases in evolution. We demonstrate that the pTBM shows no binding to tankyrase ARC domains, but it has structural and functional roles. We show, using recombinant proteins, that PTEN is not a tankyrase binding partner and substrate, and that catalytic ...
Chiara Bosetti, Albert Galera‐Prat, Anette Schmidt, Johan Pääkkönen, Aki Manninen, Lari Lehtiö   +5 more
wiley   +1 more source

PARP14 is an interferon-induced host factor that promotes IFN production and affects the replication of multiple viruses

mBio
PARP14 is a 203 kDa multi-domain protein that is primarily known as an ADP-ribosyltransferase and is involved in a variety of cellular functions, including DNA damage, microglial activation, inflammation, and cancer progression.
Srivatsan Parthasarathy, Pradtahna Saenjamsai, Hongping Hao, Anna Ferkul, Jessica J. Pfannenstiel, Daniel S. Bejan, Yating Chen, Ellen L. Suder, Nancy Schwarting, Masanori Aikawa, Elke Muhlberger, Adam J. Hume, Robin C. Orozco, Christopher S. Sullivan, Michael S. Cohen, David J. Davido, Anthony R. Fehr   +16 more
doaj   +1 more source

Achievement of high energy density and efficiency in Bi(Mg0.5Hf0.5)O3 modified Ba0.55Sr0.45TiO3 ceramics

International Journal of Applied Ceramic Technology, Volume 22, Issue 5, September/October 2025.
BMH introduction in BST lattice disrupted the long range ferroelectric domains transforming it to polar nano regions (PNRs) that lead to increased bandgap and hence increaed the dielectric breakdown field with slimer P‐E loop. Abstract (1 ‒ x)Ba0.55Sr0.45TiO3‒xBi(Mg0.5Hf0.5)O3 [(1 ‒ x)BST‒xBMH] (x = 0, 0.05, 0.10, 0.15, and 0.20) ceramics were ...
Ihsan Ullah, Abdul Manan, Rajwali Khan, Maqbool Ur Rehman, Raz Muhammad, Gang Liu, Amjad A. Almunyif, Shabir Ali   +7 more
wiley   +1 more source

Large High‐Temperature Piezoelectric Response of Lead‐free BiFeO3–BaTiO3 Originating from Relaxor Disorder

Small, Volume 21, Issue 31, August 7, 2025.
In situ, temperature‐dependent analysis of the piezoelectric response of the 0.67BFO‐0.33BTO system reveals an exceptionally high piezoelectric response of ≈1200 pm V−1. Detailed temperature‐dependent examination uncovers three distinct stages, mutually contributing to the overall response.
Antonio Iacomini, Janina Roknić, Issa Sidibe, Marco Scavini, Mojca Otoničar, Hana Uršič, Tadej Rojac   +6 more
wiley   +1 more source

Synthesis of Amphiphilic Naphthalenediimides and Investigation of their Bioimaging Potential in Large Unilamellar Vesicles

European Journal of Organic Chemistry, Volume 28, Issue 28, July 29, 2025.
The efficient synthesis of a small library of nonsymmetrical panchromatic naphthalenediimides is reported. The electron‐donating groups on the aromatic core are varied to tune the fluorophores' photophysical properties . The ability of the dyes to partition and light up inside the lipid bilayer membrane in liposomal models is investigated to evaluate ...
Francesca Cardano, Federica Micheletto, Giada Fregnan, Giacomo Renno, Paolo Ettore Porporato, Andrea Fin   +5 more
wiley   +1 more source

Acid Sphingomyelinase Promotes Endothelial Stress Response in Systemic Inflammation and Sepsis

Molecular Medicine, 2016
The pathophysiology of sepsis involves activation of acid sphingomyelinase (SMPD1) with subsequent generation of the bioactive mediator ceramide. We herein evaluate the hypothesis that the enzyme exerts biological effects in endothelial stress response ...
Ha-Yeun Chung, Daniel C Hupe, Gordon P Otto, Marcel Sprenger, Alexander C Bunck, Michael J Dorer, Clemens L Bockmeyer, Hans-Peter Deigner, Markus H Gräler, Ralf A Claus   +9 more
doaj   +1 more source

Interactomics of SARS-CoV-2 Macrodomain 1 Reveals Putative Clients of ADP-Ribosyl Hydrolase Activity

Viruses
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has greatly impacted public health due to high rates of transmissibility and mutation during the COVID-19 pandemic.
Crissey D. Cameron, Grace Heilmann, Brynn K. Roman, Lars Plate   +3 more
doaj   +1 more source

The study of dynamic characteristics during the vibration processing of parts

MATEC Web of Conferences, 2018
The results of theoretical studies on the dynamic characteristics of the process of vibroprocessing are presented, the essence of which is to create conservative zones limited by the current lines of a certain fixed vector field, which contributes to the
Levchenko Elena
doaj   +1 more source

The Bacterial DNA Binding Protein MatP Involved in Linking the Nucleoid Terminal Domain to the Divisome at Midcell Interacts with Lipid Membranes

mBio, 2019
Division ring formation at midcell is controlled by various mechanisms in Escherichia coli, one of them being the linkage between the chromosomal Ter macrodomain and the Z-ring mediated by MatP, a DNA binding protein that organizes this macrodomain and ...
Begoña Monterroso, Silvia Zorrilla, Marta Sobrinos-Sanguino, Miguel Ángel Robles-Ramos, Carlos Alfonso, Bill Söderström, Nils Y. Meiresonne, Jolanda Verheul, Tanneke den Blaauwen, Germán Rivas   +9 more
doaj   +1 more source