Results 81 to 90 of about 2,256 (152)

PanDDA analysis of fragment screen against the Nsp3 macrodomain of SARS-CoV-2 - P43 crystals at UCSF

, 2021
This deposition contains the X-ray diffraction data used for the PanDDA analysis of the fragment screen against the NSP3 macrodomain of SARS-CoV-2 described in Schuller et al. 2021 (DOI: 10.1126/sciadv.abf8711).
Thompson, Michael C., Fraser, James S., Correy, Galen J., Young, Iris D.   +3 more
core   +1 more source

Dynamic distribution of SeqA protein across the chromosome of Escherichia coli K-12 [PDF]

, 2010
The bacterial SeqA protein binds to hemi-methylated GATC sequences that arise in newly synthesized DNA upon passage of the replication machinery. In Escherichia coli K-12, the single replication origin oriC is a well-characterized target for SeqA, which ...
Stephen J. W. Busby, Nigel P. Dyer, Sascha Ott, Sánchez-Romero, María Antonia, Dyer, NP, Millard, AD, Sanchez-Romero, MA, María Antonia Sánchez-Romero, Busby, Stephen; id_orcid, Ott, S, Grainger, David, Dyer, Nigel, Millard, Andrew D., David C. Grainger, Ott, Sascha, Andrew D. Millard, Busby, S. (Stephen), Grainger, David C.   +17 more
core   +1 more source

PanDDA files from a ligand screen against the NSP3 macrodomain of SARS-CoV-2 - ligands from fragment merging/linking and virtual screening

, 2022
This deposition contains the X-ray diffraction datasets used to run PanDDA in the ligand screen against the NSP3 macrodomain of SARS-CoV-2 described in Gahbauer et al. 2022.
Fraser, James S., Correy, Galen J.
core   +1 more source

The Bacterial DNA Binding Protein MatP Involved in Linking the Nucleoid Terminal Domain to the Divisome at Midcell Interacts with Lipid Membranes

mBio, 2019
Division ring formation at midcell is controlled by various mechanisms in Escherichia coli, one of them being the linkage between the chromosomal Ter macrodomain and the Z-ring mediated by MatP, a DNA binding protein that organizes this macrodomain and ...
Begoña Monterroso, Silvia Zorrilla, Marta Sobrinos-Sanguino, Miguel Ángel Robles-Ramos, Carlos Alfonso, Bill Söderström, Nils Y. Meiresonne, Jolanda Verheul, Tanneke den Blaauwen, Germán Rivas   +9 more
doaj   +1 more source

Identification of macrodomain proteins as novel O-acetyl-ADP-ribose deacetylases. [PDF]

, 2011
Sirtuins are a family of protein lysine deacetylases, which regulate gene silencing, metabolism, life span, and chromatin structure. Sirtuins utilize NAD(+) to deacetylate proteins, yielding O-acetyl-ADP-ribose (OAADPr) as a reaction product.
Denu, JM, Rossi, Marianna N, Melanie Vollmar, Slade, Dea, Gileadi, Opher, Ahel, I, Pawan V. Mehrotra, Gileadi, O, Opher Gileadi, von Delft, F, Rolf Kraehenbuehl, Dea Slade, Phillips, Claire, Susan K. Crosthwaite, Vollmar, M, Vollmar, Melanie, Chen, D, Rossi, Marianna N., Crosthwaite, Susan K, Claire Phillips, Mehrotra, Pawan V., Frank von Delft, Crosthwaite, Susan K., von Delft, Frank, Kraehenbuehl, R, Dawei Chen, Mehrotra, PV, Kraehenbuehl, Rolf, Ivan Ahel, Rossi, MN, Chen, Dawei, Ahel, Ivan, Marianna N. Rossi, Denu, John M, John M. Denu, Mehrotra, Pawan V, Denu, John M., Phillips, C, Slade, D, Crosthwaite, SK   +39 more
core   +1 more source

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation

The EMBO Journal
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Kang Zhu, Evgeniia Prokhorova, Nicolas Bigot, Domagoj Baretić, Juraj Ahel, Jonas Damgaard Elsborg, Michael L Nielsen, Tim Clausen, Sébastien Huet, Mario Niepel, Sumana Sanyal, Dragana Ahel, Rebecca Smith, Ivan Ahel   +18 more
doaj   +1 more source

The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism

Frontiers in Genetics, 2018
The exchange of replication-coupled canonical histones by histone variants endows chromatin with specific features. The replacement of the canonical H2A histone for the histone variant macroH2A is one of the most remarkable epigenetic modifications.
Sarah Hurtado-Bagès, Sarah Hurtado-Bagès, Iva Guberovic, Iva Guberovic, Marcus Buschbeck, Marcus Buschbeck   +5 more
doaj   +1 more source

PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation

The EMBO Journal
Protein ADP-ribosylation plays important but ill-defined roles in antiviral signalling cascades such as the interferon response. Several viruses of clinical interest, including coronaviruses, express hydrolases that reverse ADP-ribosylation catalysed by ...
Victoria Chaves Ribeiro, Lilian Cristina Russo, Nícolas Carlos Hoch   +2 more
doaj   +1 more source

Probability amplitude description of the dynamics of charged particles in a magnetic field in the macrodomain

, 2001
The set of Schrödinger-like equations obtained earlier by the author [Phys. Rev. Lett. 26, 417 (1971), Phys. Rev. A 31, 3951 (1985)] for the charged particle dynamics in an inhomogeneous magnetic field in the macrodomain, are derived here starting ...
Varma, Ram K.
core   +1 more source

Functions of Alphavirus Macrodomain-containing protein nsP3 [PDF]

, 2011
Alphaviruses are positive strand RNA viruses that replicate in association with cellular membranes. The viral RNA replication complex consists of four non-structural proteins nsP1-nsP4 which are essential for viral replication.
Neuvonen, Maarit
core