Results 81 to 90 of about 4,884 (228)

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation [PDF]

Nature Structural & Molecular Biology, 2013
ADP-ribosylation is a reversible post-translational modification with wide-ranging biological functions in all kingdoms of life. A variety of enzymes use NAD(+) to transfer either single or multiple ADP-ribose (ADPr) moieties onto distinct amino acid substrates, often in response to DNA damage or other stresses.
Jankevicius, Gytis, Hassler, Markus, Golia, Barbara, Rybin, Vladimir, Zacharias, Martin, Timinszky, Gyula, Ladurner, Andreas G   +6 more
openaire   +2 more sources

Long range chromosome organization in Escherichia coli: The position of the replication origin defines the non-structured regions and the Right and Left macrodomains. [PDF]

PLoS Genetics, 2017
The Escherichia coli chromosome is organized into four macrodomains (Ori, Ter, Right and Left) and two non-structured regions. This organization influences the segregation of sister chromatids, the mobility of chromosomal DNA, and the cellular ...
Stéphane Duigou, Frédéric Boccard
doaj   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Superconductivity in Sr2RuO4-Sr3Ru2O7 eutectic crystals

, 2007
Superconducting behavior has been observed in the Sr2RuO4-Sr3Ru2O7 eutectic system as grown by the flux-feeding floating zone technique. A supercurrent flows across a single interface between Sr2RuO4 and Sr3Ru2O7 areas at distances that are far beyond ...
Born, D., Ciancio, R., Cuoco, M., Fittipaldi, R., Kittaka, S., Maeno, Y., Olsson, E., Pace, S., Stornaiuolo, D., Tafuri, F., Vecchione, A., Yaguchi, H.   +11 more
core   +1 more source

Molecular Insights into Poly(ADP-ribose) Recognition and Processing

Biomolecules, 2012
Poly(ADP-ribosyl)ation is a post-translational protein modification involved in the regulation of important cellular functions including DNA repair, transcription, mitosis and apoptosis.
Ivan Ahel, Eva Barkauskaite, Roko Žaja, Andreja Mikoč   +3 more
doaj   +1 more source

Multiorgan Molecular Landscape of Severe COVID‐19 Revealed by Consensus Gene Signatures and RAB8B Targeting

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Severe COVID‐19 involves hyperinflammation and multiorgan pathology, but consistent gene signatures remain elusive. We aimed to identify consensus transcriptomic signatures and molecular mechanisms in severe COVID‐19. We performed an integrative analysis of 39 studies spanning 11 tissue types, 1551 bulk RNA‐seq samples, and over 2 million ...
Jonathan Peña Avila, Peter Park, Youvika Singh, Paulo P. Amaral, Ícaro Castro, Felipe Ten‐Caten, Viviane Schuch, André N. A. Gonçalves, Jeevan Giddaluru, Mauro César Cafundó Morais, Rodrigo L. T. Ogava, Thiago Lubiana, Gabriel Amoroso de Castro, Rodrigo Aquino, Luiz Durão, Júlia Raspante Martins, Leandro Jimenez, André G. Costa‐Martins, Patrícia Gonzalez‐Dias, Thiago Dominguez Crespo Hirata, Thomaz Lüscher Dias, Débora Guerra Peixe, Adriana Simizo, Juan Carlo Santos e Silva, Amanda Pereira Vasconcelos, Marcelo Berçot Rodrigues, Bianca G. Castelucci, João Victor Virgillio‐da‐Silva, Larissa Menezes, Pedro M. Moraes‐Vieira, Otavio Cabral‐Marques, Helder I. Nakaya   +31 more
wiley   +1 more source

A macrodomain-linked immunosorbent assay (MLISA) for mono-ADP-ribosyltransferases [PDF]

Analytical Biochemistry, 2018
ADP-ribosyltransferases (ARTs) catalyze reversible additions of mono- and poly-ADP-ribose onto diverse types of proteins by using nicotinamide adenine dinucleotide (NAD+) as a cosubstrate. In the human ART superfamily, 14 out of 20 members are shown to catalyze endogenous protein mono-ADP-ribosylation and play important roles in regulating various ...
Jingwen, Chen, Albert T, Lam, Yong, Zhang   +2 more
openaire   +2 more sources

Streptomyces coelicolor macrodomain hydrolase SCO6735 cleaves thymidine-linked ADP-ribosylation of DNA

Computational and Structural Biotechnology Journal, 2022
ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes.
Andrea Hloušek-Kasun, Petra Mikolčević, Johannes Gregor Matthias Rack, Callum Tromans-Coia, Marion Schuller, Gytis Jankevicius, Marija Matković, Branimir Bertoša, Ivan Ahel, Andreja Mikoč   +9 more
doaj   +1 more source

Design, synthesis and evaluation of inhibitors of the SARS-CoV-2 nsp3 macrodomain

bioRxiv, 2022
A series of amino acid based 7H-pyrrolo[2,3-d]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for coronavirus replication ...
Lavinia M. Sherrill, Elva E. Joya, A. Walker, Anuradha Roy, Yousef M. O. Alhammad, Mo Atobatele, S. Wazir, G. Abbas, P. Keane, J. Zhuo, A. Leung, David K. Johnson, L. Lehtiö, Anthony R. Fehr, D. Ferraris   +14 more
semanticscholar   +1 more source

Recent advances in noncanonical inhibition mechanisms of anti‐CRISPR proteins

mLife, Volume 5, Issue 2, Page 133-147, April 2026.
Abstract The CRISPR‐Cas system constitutes an adaptive immune mechanism in prokaryotes that defends against mobile genetic elements. Within the perpetual co‐evolutionary arms race between bacteria and their viral predators, bacteriophages encode anti‐CRISPR (Acr) proteins that use sophisticated molecular strategies to sabotage CRISPR‐Cas function ...
Lingguang Yang, Rongjun Luo, Wei Zhou, Peipei Yin, Yue Feng, Yi Zhang   +5 more
wiley   +1 more source