Results 91 to 100 of about 1,793 (163)

PARP14 and PARP9/DTX3L regulate interferon-induced ADP-ribosylation

The EMBO Journal
PARP-catalysed ADP-ribosylation (ADPr) is important in regulating various cellular pathways. Until recently, PARP-dependent mono-ADP-ribosylation has been poorly understood due to the lack of sensitive detection methods.
Pulak Kar, Chatrin Chatrin, Nina Đukić, Osamu Suyari, Marion Schuller, Kang Zhu, Evgeniia Prokhorova, Nicolas Bigot, Domagoj Baretić, Juraj Ahel, Jonas Damgaard Elsborg, Michael L Nielsen, Tim Clausen, Sébastien Huet, Mario Niepel, Sumana Sanyal, Dragana Ahel, Rebecca Smith, Ivan Ahel   +18 more
doaj   +1 more source

The MacroH2A1.1 – PARP1 Axis at the Intersection Between Stress Response and Metabolism

Frontiers in Genetics, 2018
The exchange of replication-coupled canonical histones by histone variants endows chromatin with specific features. The replacement of the canonical H2A histone for the histone variant macroH2A is one of the most remarkable epigenetic modifications.
Sarah Hurtado-Bagès, Sarah Hurtado-Bagès, Iva Guberovic, Iva Guberovic, Marcus Buschbeck, Marcus Buschbeck   +5 more
doaj   +1 more source

Synthesis and Macrodomain Binding of Gln‐carba‐ADPr‐peptide

ChemBioChem
AbstractMono‐ADP‐ribosylation is a dynamic post‐translational modification (PTM) with important roles in cell signalling. This modification occurs on a wide variety of amino acids, and one of the canonical modification sites within proteins is the side chain of glutamic acid. Given the transient nature of this modification (acylal linkage) and the high
Sander B. Engelsma, Aurelio Pio Nardozza, Pieter de Saint Aulaire, Herman S. Overkleeft, Gijsbert A. van der Marel, Andreas G. Ladurner, Dmitri V. Filippov   +6 more
openaire   +2 more sources

PARP7 is a proteotoxic stress sensor that labels proteins for degradation

The EMBO Journal
ADP-ribosylation is a post-translational modification that plays a critical role in cellular stress responses. We have observed that during proteotoxic stress, cellular ADP-ribosylation increases, with ADP-ribosylated proteins accumulating in cytoplasmic
Nonso J Ikenga, Jörg Vervoorts, Bernhard Lüscher, Roko Žaja, Karla L H Feijs-Žaja   +4 more
doaj   +1 more source

In silico analysis of the Chikungunya virus and SARS-CoV-2 Macrodomain

Computational and Structural Biotechnology Reports
Abstract The macrodomain of the Chikungunya virus NSP3 protein (ChikV Mac1) hydrolyzes mono-ADP ribose post-translational modifications on the human host proteins. Mutations in Mac1 reduce ChikV virulence. Thus, ChikV Mac1 is a viral drug target.
Vikas Tiwari, Moira Rachman, Kenneth Huang, Ignacia Echeverria, Andrej Sali   +4 more
openaire   +2 more sources

READDI protocol: Crystallisation of CHIKV nsP3 macrodomain v1

Chikungunya virus (CHIKV) causes severe fever, rash and debilitating joint pain that can last for months or even years. Millions of people have been infected with CHIKV, mostly in low- and middle-income countries, and the virus continues to spread into new areas due to the geographical expansion of its mosquito hosts.
Jasmin Aschenbrenner, Peter Marples, michael fairhead, Andre Schutzer de Godoy, Daren Fearon   +4 more
openaire   +1 more source

CHD1L maintains genome integrity by facilitating okazaki fragment maturation. [PDF]

Nucleic Acids Res
Nie L, Fu J, Huang M, Zhang H, Ma T, Yang C, Li S, Wang C, Chen J.   +8 more
europepmc   +1 more source

READDI protocol: Crystallisation of CHIKV nsP3 macrodomain v2

The crystallization protocol and buffer conditions used to obtain reproducible Chikungunya Virus NS3 macrodomain crystals suitable for XChem fragment screening.
Jasmin Aschenbrenner, Peter Marples, michael fairhead, Andre Schutzer de Godoy, Daren Fearon   +4 more
openaire   +1 more source

Noncovalent PAR Binding Guides Proteins to PARP1-Mediated PARylation. [PDF]

ACS Chem Biol
Fischbach A, Bangert K, Bürkle A, Mangerich A.   +3 more
europepmc   +1 more source

The Expanding Landscape of ADP-Ribosylation: Protein, DNA, RNA, and Mitochondrial Regulation. [PDF]

Chem Res Toxicol
Sin YC, Zhao L.
europepmc   +1 more source