Results 111 to 120 of about 4,884 (228)

New approaches to understanding the spatial organization of bacterial genomes [PDF]

, 2014
In all organisms, chromosomal DNA must be compacted nearly three orders of magnitude to fit within the limited volume of a cell. However, chromosomes cannot be haphazardly packed, and instead must adopt structures compatible with numerous cellular ...
Laub, Michael T, Le, Tung
core   +1 more source

Calcium regulation of muscle spindle mechanosensory afferent function

Experimental Physiology, Volume 110, Issue 10, Page 1457-1472, October 1, 2025.
Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon, Richard A. Lofthouse, Philip Miti, Claudiu V. Giuraniuc, Robert W. Banks, Guy S. Bewick   +5 more
wiley   +1 more source

Structurally flexible macro-organization of the pigment-protein complexes of the diatom Phaeodactylum tricornutum [PDF]

, 2008
By means of circular dichroism (CD) spectroscopy, we have characterized the organization of the photosynthetic complexes of the diatom Phaeodactylum tricornutum at different levels of structural complexity: in intact cells, isolated thylakoid membranes ...
Garab, G, Goss, R, Lepetit, B, Mustárdy, L, Szabó, M, Wilhelm, C   +5 more
core   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Electric-field-induced phase transition of <001> oriented Pb(Mg1/3Nb2/3)O3-PbTiO3 single crystals

, 2002
oriented 0.7Pb(Mg1/3Nb2/3)O3-0.3PbTiO3 single crystals were poled under different electric fields, i.e. Epoling=4 kV/cm and Epoling=13 kV/cm. In addition to the temperature-dependent dielectric constant measurement, X-ray diffraction was also used to ...
Cullity B D, Hao-Su Luo, Ke-Pi Chen, Kleemann W, Kuwata J, Kuwata J, Noheda B, Noheda B, Singh A K, Xiao-Wen Zhang, Zhang X W   +10 more
core   +1 more source

PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease

MedComm, Volume 6, Issue 9, September 2025.
PARP family orchestrates ADP‐ribosylation to regulate genomic stability (DNA repair, telomeres) and metabolism (NAD⁺, glucose/lipid). Physiological roles sustain health; dysregulation drives pathologies: cancer (DNA repair addiction), neurodegeneration (parthanatos), cardiovascular disorders (hypertrophy/fibrosis), inflammation (dual role), and viral ...
Pengyuan Lei, Wenfeng Li, Jinhua Luo, Nanxin Xu, Yahe Wang, Dafei Xie, Hua Guan, Bo Huang, Xin Huang, Pingkun Zhou   +9 more
wiley   +1 more source

Asymptotic Analysis of Stokes Flow Through a Filter

Mathematical Methods in the Applied Sciences, Volume 48, Issue 13, Page 12913-12934, September 2025.
ABSTRACT This paper investigates the Stokes flow through a thin porous layer composed of a rigid, thin, periodic, and closely packed array of parallel long rods with a noncircular, anisotropic cross‐section in the shape of a slot. This shape allows for the construction of a thicker permeable filter than what is known as the Brinkman critical size.
Georges Griso, Larysa Khilkova, Julia Orlik   +2 more
wiley   +1 more source

Evolution of the Hepatitis E virus hypervariable region [PDF]

, 2012
The presence of a hypervariable (HVR) region within the genome of hepatitis E virus (HEV) remains unexplained. Previous studies have described the HVR as a proline-rich spacer between flanking functional domains of the ORF1 polyprotein.
Arankalle, Donald B. Smith, Erker, Ingolfur Johannessen, Jeff Vanek, Kate Templeton, Kay, Kayman, Meng, Miyashita, Ott, Peter Simmonds, Sandeep Ramalingam, Williamson, Wu   +14 more
core   +1 more source

Phosphatidylserine regulates plasma membrane repair through tetraspanin-enriched macrodomains

Journal of Cell Biology
The integrity of the plasma membrane is critical to cell function and survival. Cells have developed multiple mechanisms to repair damaged plasma membranes. A key process during plasma membrane repair is to limit the size of the damage, which is facilitated by the presence of tetraspanin-enriched rings surrounding damage sites.
Yang E. Li, Dougall M. Norris, Fanqian N. Xiao, Elvis Pandzic, Renee M. Whan, Sandra Fok, Ming Zhou, Guangwei Du, Yang Liu, Ximing Du, Hongyuan Yang   +10 more
openaire   +2 more sources

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis [PDF]

Journal of Virology, 2015
ABSTRACT All coronaviruses encode a macrodomain containing ADP-ribose-1″-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type virus but was unable to cause ...
Anthony R, Fehr, Jeremiah, Athmer, Rudragouda, Channappanavar, Judith M, Phillips, David K, Meyerholz, Stanley, Perlman   +5 more
openaire   +2 more sources