Results 131 to 140 of about 1,793 (163)

Exploration of structure-activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment linking and active learning. [PDF]

Sci Adv
Correy GJ, Rachman MM, Togo T, Gahbauer S, Doruk YU, Stevens MGV, Jaishankar P, Kelley B, Goldman B, Schmidt M, Kramer T, Radchenko DS, Moroz YS, Ashworth A, Riley P, Shoichet BK, Renslo AR, Walters WP, Fraser JS.   +18 more
europepmc   +1 more source

Research progress on the role of host factors in Chikungunya virus infection and intervention strategies. [PDF]

Virulence
Chen Y, Zhang K, Qi Z, Ding C.
europepmc   +1 more source

A FRET-based high-throughput screening assay for the discovery of Mycobacterium tuberculosis DNA ADP-ribosylglycohydrolase DarG inhibitors

Duong MTH, Lu Y, Ahel I, Lehtiö L.
europepmc   +1 more source

LABind: identifying protein binding ligand-aware sites via learning interactions between ligand and protein. [PDF]

Nat Commun
Zhang Z, Quan L, Wang J, Peng L, Chen Q, Zhang B, Cao L, Jiang Y, Li G, Nie L, Wu T, Lyu Q.   +11 more
europepmc   +1 more source

Disrupted transcriptional networks regulated by CHD1L during neurodevelopment underlie the mirrored neuroanatomical and growth phenotypes of the 1q21.1 copy number variant. [PDF]

Nucleic Acids Res
Lemée MV, Loviglio MN, Ye T, Tilly P, Keime C, Weber C, Petrova A, Klein P, Morlet B, Wendling O, Jacobs H, Tharreau M, Geneviève D, Godin JD, Romier C, Duteil D, Golzio C.   +16 more
europepmc   +1 more source

Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication

Journal of Virology, 2021
In the wake of the COVID-19 epidemic, there has been a surge to better understand how CoVs replicate and to identify potential therapeutic targets that could mitigate disease caused by SARS-CoV-2 and other prominent CoVs. The highly conserved macrodomain, also termed Mac1, is a small domain within nonstructural protein 3.
Lynden S Voth, Joseph J O'Connor, Catherine M Kerr   +2 more
exaly   +4 more sources

Macrodomain organization of the Escherichia coli chromosome [PDF]

EMBO Journal, 2004
We have explored the Escherichia coli chromosome architecture by genetic dissection, using a site-specific recombination system that reveals the spatial proximity of distant DNA sites and records interactions. By analysing the percentages of recombination between pairs of sites scattered over the chromosome, we observed that DNA interactions were ...
François Cornet, Frédéric Boccard
exaly   +3 more sources

Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication

Antimicrobial Agents and Chemotherapy, 2021
Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses.
Sarah Wazir, Tania Quirin, Mirko M Maksimainen   +2 more
exaly   +5 more sources