Results 101 to 110 of about 4,884 (228)

Identification of Macrodomain Proteins as Novel O-Acetyl-ADP-ribose Deacetylases [PDF]

Journal of Biological Chemistry, 2011
Sirtuins are a family of protein lysine deacetylases, which regulate gene silencing, metabolism, life span, and chromatin structure. Sirtuins utilize NAD(+) to deacetylate proteins, yielding O-acetyl-ADP-ribose (OAADPr) as a reaction product. The macrodomain is a ubiquitous protein module known to bind ADP-ribose derivatives, which diverged through ...
Chen, Dawei, Vollmar, Melanie, Rossi, Marianna N., Phillips, Claire, Kraehenbuehl, Rolf, Slade, Dea, Mehrotra, Pawan V., Von Delft, Frank, Crosthwaite, Susan K., Gileadi, Opher, Denu, John M., Ahel, Ivan   +11 more
openaire   +4 more sources

Evaluation of Midwife‐Led Colposcopy for Female Genital Schistosomiasis Screening at Primary Level of Care in Rural Madagascar: A Cross‐Sectional Study

Tropical Medicine &International Health, Volume 31, Issue 1, Page 49-57, January 2026.
ABSTRACT Introduction Female genital schistosomiasis is a condition with a complex diagnosis and severe consequences such as infertility. In the absence of a reliable biomarker, in endemic settings the World Health Organization recommends colposcopy as a diagnostic tool for the detection of female genital schistosomiasis lesions.
Pia Rausche, Jean‐Marc Kutz, Zoly Rakotomalala, Bodo Sahondra Randrianasolo, Paule Donven, Rivo Solotiana Rakotomalala, Alexina Olivasoa Tsiky Zafinimampera, Olivette Totofotsy, Sonya Ratefiarisoa, Ravo Razafindrakoto, Nantenaina Matthieu Razafindralava, Zaraniaina Tahiry Rasolojaona, Jana Hey, Aaron Remkes, Tahinamandranto Rasamoelina, Eva Lorenz, Rapahel Rakotozandrindrainy, Jürgen May, Monika Hampl, Irina Kislaya, Valentina Marchese, Rivo Andry Rakotoarivelo, Daniela Fusco   +22 more
wiley   +1 more source

Synthesis of Structural ADP-Ribose Analogues as Inhibitors for SARS-CoV-2 Macrodomain 1

Organic Letters
Protein adenosine diphosphate (ADP)-ribosylation is crucial for a proper immune response. Accordingly, viruses have evolved ADP-ribosyl hydrolases to remove these modifications, a prominent example being the SARS-CoV-2 NSP3 macrodomain, “Mac1 ...
Koen J Rijpkema, Marion Schuller, Miriam S van der Veer, Sjoerd Rieken, Diego L R Chang, Pascal Balić, Alex Todorov, Hugo Minnee, Sven Wijngaarden, I. A. Matos, N. C. Hoch, J. Codée, I. Ahel, D. Filippov   +13 more
semanticscholar   +1 more source

Analysis Crystal Structure of Sars-cov-2 Nsp3 Macrodomain Based on Optimal Multi Level of Deep Neurocomputing Technique (preprint)

, 2023
In an attempt to improve the analysis crystal structure of sars-cov-2 nsp3 macrodomain, a new deep learning neural network architecture called (DLSTM) is established in this work which combines a novel meta-heuristic optimization algorithm called (Lion ...
Samaher Al-Janabi, A. Alkaim
semanticscholar   +1 more source

The Transcriptome of Streptococcus pneumoniae Induced by Local and Global Changes in Supercoiling [PDF]

, 2017
The bacterial chromosome is compacted in a manner optimal for DNA transactions to occur. The degree of compaction results from the level of DNA-supercoiling and the presence of nucleoid-binding proteins.
Adela G. de la Campa, Adela G. de la Campa, Antonio J. Martín-Galiano, Jose M. Tirado-Vélez, María J. Ferrándiz, María T. García   +5 more
core   +5 more sources

Disruption of Macrodomain Protein SCO6735 Increases Antibiotic Production in Streptomyces coelicolor [PDF]

Journal of Biological Chemistry, 2016
ADP-ribosylation is a post-translational modification that can alter the physical and chemical properties of target proteins and that controls many important cellular processes. Macrodomains are evolutionarily conserved structural domains that bind ADP-ribose derivatives and are found in proteins with diverse cellular functions.
Lalic J, Posavec-Marjanović M, Palazzo L, Perina D, Sabljić I, Žaja R, Colby T, Pleše B, Halasz M, Jankevicius G, Bucca G, Ahel M, Matic I, Ćetković H, Luić M, Mikoč A, Ahel I.   +16 more
openaire   +7 more sources

Extensive exploration of structure activity relationships for the SARS-CoV-2 macrodomain from shape-based fragment merging and active learning

bioRxiv
The macrodomain contained in the SARS-CoV-2 non-structural protein 3 (NSP3) is required for viral pathogenesis and lethality. Inhibitors that block the macrodomain could be a new therapeutic strategy for viral suppression. We previously performed a large-
G. Correy, Moira M. Rachman, Takaya Togo, Stefan Gahbauer, Yagmur U. Doruk, Maisie G. V. Stevens, P. Jaishankar, Brian Kelley, Brian Goldman, Molly Schmidt, Trevor Kramer, Alan Ashworth, Patrick Riley, B. Shoichet, A. Renslo, W. P. Walters, J. Fraser   +16 more
semanticscholar   +1 more source

Discovery of potent SARS-CoV-2 nsp3 macrodomain inhibitors uncovers lack of translation to cellular antiviral response

bioRxiv
A strategy for pandemic preparedness is the development of antivirals against a wide set of viral targets with complementary mechanisms of action. SARS-CoV-2 nsp3-mac1 is a viral macrodomain with ADP-ribosylhydrolase activity, which counteracts host ...
Alpha A. Lee, Isabelle Amick, J. C. Aschenbrenner, H. Barr, Jared Benjamin, Alexander Brandis, Galit Cohen, Randy Diaz-tapia, Shirly Duberstein, J. Dixon, David Cousins, Michael Fairhead, D. Fearon, James M Frick, James Gayvert, A. S. Godoy, Ed J. Griffin, Kilian V. M. Huber, L. Koekemoer, Noa Lahav, P. Marples, B. McGovern, Tevie Mehlman, Matthew C Robinson, Usha Singh, T. Szommer, C. Tomlinson, Thomas R Vargo, Frank von Delft, Siyi Wang, Kris M. White, E. Williams, M. Winokan   +32 more
semanticscholar   +1 more source

Unscreened Polaron Ordering Against High Electron Density on Mechanically Cleaved Surfaces of WO3 (001) Films

Small, Volume 21, Issue 39, October 2, 2025.
Unscreened high‐density polarons are discovered in a metallic WO3 (001) 2DEG, stabilized by surface oxygen vacancies and c(2 × 2) reconstruction. ARPES and STM/STS reveal polaron formation and ordering, supported by first‐principles calculations. This work opens new avenues for exploring collective polaron phenomena, including bipolaron interactions ...
Gyubin Lee, Jeongdae Seo, Wooin Yang, Ji‐Ho Mun, Minho Kang, Ho‐Hyun Nahm, Yong‐Hyun Kim, Tae‐Hwan Kim, Chan‐Ho Yang, Yeongkwan Kim   +9 more
wiley   +1 more source

The Gap-Tooth Method in Particle Simulations

, 2003
We explore the gap-tooth method for multiscale modeling of systems represented by microscopic physics-based simulators, when coarse-grained evolution equations are not available in closed form.
C.William Gear, Chertock, Chertock, Cole, E, Gear, Gear, Gear, Hopf, Ioannis G Kevrekidis, Ju Li, Li, Li, Li, Li, Lucy, Ogata, Phillips, Roberts, Van Vliet   +19 more
core   +1 more source