Results 71 to 80 of about 1,800 (162)

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.

PLoS ONE, 2021
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence.
Sixue Zhang, Atefeh Garzan, Nicole Haese, Robert Bostwick, Yohanka Martinez-Gzegozewska, Lynn Rasmussen, Daniel N Streblow, Mark T Haise, Ashish K Pathak, Corinne E Augelli-Szafran, Mousheng Wu   +10 more
doaj   +1 more source

Host Factor Nucleophosmin 1 (NPM1/B23) Exerts Antiviral Effects against Chikungunya Virus by Its Interaction with Viral Nonstructural Protein 3

Microbiology Spectrum, 2023
Chikungunya virus (CHIKV) hijacks host cell machinery to support its replication. Nucleophosmin 1 (NPM1/B23), a nucleolar phosphoprotein, is one of the host proteins known to restrict CHIKV infection; however, the mechanistic details of the antiviral ...
Parvanendhu Pradeep, Krishnankutty Chandrika Sivakumar, Easwaran Sreekumar   +2 more
doaj   +1 more source

ITM2B Truncation Promotes Migrasome Formation to Accelerate Renal Cell Carcinoma Growth

Advanced Science, Volume 13, Issue 4, 19 January 2026.
This study identifies truncated ITM2B as a regulator of migrasome formation in renal cell carcinoma (RCC) cells. The ITM2B truncation not only facilitates migrasome formation by recruiting TSPAN4, but also sorts active caspase‐7 into migrasomes. The internalization of active caspase‐7‐enriched migrasomes by macrophages stimulates IL‐6 secretion to ...
Qi‐tao Chen, Qiao‐ling Huang, Ming‐zhi Han, Xue‐hui Hong, De‐yi Feng, Lu‐ming Yao, Wen‐bin Hong, Yue Chen, Ya‐ying Huang, Hang‐zi Chen, Qiao Wu   +10 more
wiley   +1 more source

Ferroelectricity restoration via thermally driven recovery of surface damage layers in BiFeO3‐based lead‐free ceramics

Journal of the American Ceramic Society, Volume 109, Issue 1, January 2026.
In BiFeO3‐based lead‐free ceramics, ferroelectric polarization is suppressed by a polishing‐induced surface damage layer through the inhibition of Bi3⁺ off‐centering and nanoscale domain formation. Upon thermal annealing, the damaged layer is relaxed, Bi3⁺ displacement is restored, and nanoscale domains are reactivated, resulting in the recovery of the
Sangwook Kim, Hyunwook Nam, Hae In Choi
wiley   +1 more source

Evaluation of Midwife‐Led Colposcopy for Female Genital Schistosomiasis Screening at Primary Level of Care in Rural Madagascar: A Cross‐Sectional Study

Tropical Medicine &International Health, Volume 31, Issue 1, Page 49-57, January 2026.
ABSTRACT Introduction Female genital schistosomiasis is a condition with a complex diagnosis and severe consequences such as infertility. In the absence of a reliable biomarker, in endemic settings the World Health Organization recommends colposcopy as a diagnostic tool for the detection of female genital schistosomiasis lesions.
Pia Rausche, Jean‐Marc Kutz, Zoly Rakotomalala, Bodo Sahondra Randrianasolo, Paule Donven, Rivo Solotiana Rakotomalala, Alexina Olivasoa Tsiky Zafinimampera, Olivette Totofotsy, Sonya Ratefiarisoa, Ravo Razafindrakoto, Nantenaina Matthieu Razafindralava, Zaraniaina Tahiry Rasolojaona, Jana Hey, Aaron Remkes, Tahinamandranto Rasamoelina, Eva Lorenz, Rapahel Rakotozandrindrainy, Jürgen May, Monika Hampl, Irina Kislaya, Valentina Marchese, Rivo Andry Rakotoarivelo, Daniela Fusco   +22 more
wiley   +1 more source

Unscreened Polaron Ordering Against High Electron Density on Mechanically Cleaved Surfaces of WO3 (001) Films

Small, Volume 21, Issue 39, October 2, 2025.
Unscreened high‐density polarons are discovered in a metallic WO3 (001) 2DEG, stabilized by surface oxygen vacancies and c(2 × 2) reconstruction. ARPES and STM/STS reveal polaron formation and ordering, supported by first‐principles calculations. This work opens new avenues for exploring collective polaron phenomena, including bipolaron interactions ...
Gyubin Lee, Jeongdae Seo, Wooin Yang, Ji‐Ho Mun, Minho Kang, Ho‐Hyun Nahm, Yong‐Hyun Kim, Tae‐Hwan Kim, Chan‐Ho Yang, Yeongkwan Kim   +9 more
wiley   +1 more source

Calcium regulation of muscle spindle mechanosensory afferent function

Experimental Physiology, Volume 110, Issue 10, Page 1457-1472, October 1, 2025.
Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon, Richard A. Lofthouse, Philip Miti, Claudiu V. Giuraniuc, Robert W. Banks, Guy S. Bewick   +5 more
wiley   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

Vascular Immunotargeting to Endothelial Surface in a Specific Macrodomain in Alveolar Capillaries

American Journal of Respiratory and Critical Care Medicine, 2001
Abstract A novel 85 kD glycoprotein (gp85) is a marker of the avesicular zone, a thin part of pulmonary endothelial cells separating alveolar and vascular compartments and lacking vesicles. This report presents the first evaluation whether mAb 30B3, a monoclonal antibody to gp85, can be used for targeting of drugs to the surface of ...
Murciano, Juan Carlos, Harshaw, David W., GHITESCU, LUCIAN, DANILOV, SERGEI M., Muzykantov, Vladimir R.   +4 more
openaire   +3 more sources

PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease

MedComm, Volume 6, Issue 9, September 2025.
PARP family orchestrates ADP‐ribosylation to regulate genomic stability (DNA repair, telomeres) and metabolism (NAD⁺, glucose/lipid). Physiological roles sustain health; dysregulation drives pathologies: cancer (DNA repair addiction), neurodegeneration (parthanatos), cardiovascular disorders (hypertrophy/fibrosis), inflammation (dual role), and viral ...
Pengyuan Lei, Wenfeng Li, Jinhua Luo, Nanxin Xu, Yahe Wang, Dafei Xie, Hua Guan, Bo Huang, Xin Huang, Pingkun Zhou   +9 more
wiley   +1 more source