Results 71 to 80 of about 4,884 (228)

Serine ADP-ribosylation reversal by the hydrolase ARH3

eLife, 2017
ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of ADPr,
Pietro Fontana, Juan José Bonfiglio, Luca Palazzo, Edward Bartlett, Ivan Matic, Ivan Ahel   +5 more
doaj   +1 more source

Orthorhombically Mixed s and d$_{x^2-y^2}$ Wave Superconductivity and Josephson Tunneling

, 1995
The effect of orthorhombicity on Josephson tunneling in high T$_c$ superconductors such as YBCO is studied for both single crystals and highly twinned crystals. It is shown that experiments on highly twinned crystals experimentally determine the symmetry
A. G. Sun, A. J. Millis, A. Mathai, A. S. Katz, C. C. Tsuei, C. O'Donovan, D. A. Brawner, D. A. Wollman, D.A. Wollman, I. Iguchi, M. B. Walker, M. Sigrist, P. Chaudhari, Q.P. Li, R.C. Dynes, R.H. Hazen, V. B. Geshkenbein, V. B. Geshkenbein   +17 more
core   +1 more source

An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication [PDF]

, 2021
ABSTRACTAll coronaviruses (CoVs) contain a macrodomain, also termed Mac1, in non-structural protein 3 (nsp3) which binds and hydrolyzes ADP-ribose covalently attached to proteins. Despite several reports demonstrating that Mac1 is a prominent virulence factor, there is still a limited understanding of its cellular roles during infection.
Lynden S. Voth, Joseph J. O’Connor, Catherine M. Kerr, Ethan Doerger, Nancy Schwarting, Parker Sperstad, David K. Johnson, Anthony R. Fehr   +7 more
openaire   +2 more sources

Chromosome structuring limits genome plasticity in Escherichia coli. [PDF]

PLoS Genetics, 2007
Chromosome organizations of related bacterial genera are well conserved despite a very long divergence period. We have assessed the forces limiting bacterial genome plasticity in Escherichia coli by measuring the respective effect of altering different ...
Emilie Esnault, Michèle Valens, Olivier Espéli, Frédéric Boccard   +3 more
doaj   +1 more source

Chromatin to Clinic: The Molecular Rationale for PARP1 Inhibitor Function. [PDF]

, 2015
Poly(ADP-ribose) polymerase 1 (PARP1) inhibitors were recently shown to have potential clinical impact in a number of disease settings, particularly as related to cancer therapy, treatment for cardiovascular dysfunction, and suppression of inflammation ...
de Bono, Johann S., Feng, Felix Y., Knudsen, Karen E, Rubin, Mark A.   +3 more
core   +2 more sources

Antiviral activity of myricetin glycosylated compounds isolated from Marcetia taxifolia against chikungunya virus

EXCLI Journal : Experimental and Clinical Sciences, 2023
The chikungunya virus (CHIKV) has produced epidemic outbreaks of significant public health impact. The clinical symptoms of this disease are fever, polyarthralgia, and skin rash, generally self-limiting, although patients may develop a chronic disabling ...
Ana Luisa Muñoz, Andrés Felipe Cuéllar, Gabriela Arévalo, Brian David Santamaría, Anny K. Rodríguez, Cristian Buendía-Atencio, Andrés Reyes Chaparro, Aldo Yair Tenorio Barajas, Nydia Alexandra Segura, Felio Bello, Alírica Suárez, Hector R. Rangel, Mónica Losada-Barragán   +12 more
doaj   +1 more source

Exploring pyrazolines as potential inhibitors of NSP3-macrodomain of SARS-CoV-2: synthesis and in silico analysis

Scientific Reports
COVID-19 has proved to be a global health crisis during the pandemic, and the emerging JN.1 variant is a potential threat. Therefore, finding alternative antivirals is of utmost priority.
Rekha R. Joshi, Harsh Gaikwad, Bhavana Soge, Abdulrahman Alshammari, Norah A. Albekairi, A. Kabra, Usha Yashwante, Baban Kolte, Pradip D. Lokhande, Rohan J. Meshram   +9 more
semanticscholar   +1 more source

Record Energy Storage Performance Metrics in Ferroelectric Hafnia‐Based Films through Heterostructure Design

Advanced Functional Materials, EarlyView.
Dielectric capacitors typically struggle to achieve both high energy storage density and high efficiency at applied voltages below 10 V. Here, we address this challenge by introducing a novel hybrid fluorite/perovskite heterostructure design that combines ultra‐high recoverable energy storage density with efficient energy release (Uf ≈ 1016 J/cm3), at ...
Ampattu R. Jayakrishnan, Nuno Estrócio, Inês Silva, Raluca Negrea, Marian C. Istrate, Koppole C. Sekhar, Luís Marques, Judith L. MacManus‐Driscoll, Ignasi Fina, Florencio Sánchez, José P. B. Silva   +10 more
wiley   +1 more source

Targeting SARS-CoV-2 Nsp3 macrodomain structure with insights from human poly(ADP-ribose) glycohydrolase (PARG) structures with inhibitors

Progress in Biophysics and Molecular Biology, 2021
Arrival of the novel SARS-CoV-2 has launched a worldwide effort to identify both pre-approved and novel therapeutics targeting the viral proteome, highlighting the urgent need for efficient drug discovery strategies.
C. Brosey, Jerry H. Houl, Panagiotis Katsonis, L.P.F. Balapiti-Modarage, S. Bommagani, A. Arvai, D. Moiani, A. Bacolla, T. Link, L. S. Warden, O. Lichtarge, Darin E. Jones, Z. Ahmed, J. Tainer   +13 more
semanticscholar   +1 more source

Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts

Cellular Microbiology, 2006
The lipopolysaccharides (LPS) of intracellular Proteobacteria such as Brucella, Chlamydia, Legionella and Rickettsia, have properties distinct from enterobacterial LPSs. These properties include deficient LPS induction of host cell activation, low endotoxicity and resistance to macrophage degradation.
Lapaque, N., Forquet, F., de Chastellier, C., Mishal, Z., Jolly, G., Moreno, E., Moriyon, I., Heuser, J.E., He, H.T., Gorvel, J.P.   +9 more
openaire   +5 more sources