Results 71 to 80 of about 1,793 (163)

The macrodomain family: Rethinking an ancient domain from evolutionary perspectives [PDF]

Chinese Science Bulletin, 2013
The reasons why certain domains evolve much slower than others is unclear. The notion that functionally more important genes evolve more slowly than less important genes is one of the few commonly believed principles of molecular evolution. The macro-domain (also known as the X domain) is an ancient, slowly evolving and highly conserved structural ...
Li, XiaoLei, Wu, ZhiQiang, Han, WeiDong
openaire   +2 more sources

Pyrimidone inhibitors targeting Chikungunya Virus nsP3 macrodomain by fragment-based drug design.

PLoS ONE, 2021
The macrodomain of nsP3 (nsP3MD) is highly conserved among the alphaviruses and ADP-ribosylhydrolase activity of Chikungunya Virus (CHIKV) nsP3MD is critical for CHIKV viral replication and virulence.
Sixue Zhang, Atefeh Garzan, Nicole Haese, Robert Bostwick, Yohanka Martinez-Gzegozewska, Lynn Rasmussen, Daniel N Streblow, Mark T Haise, Ashish K Pathak, Corinne E Augelli-Szafran, Mousheng Wu   +10 more
doaj   +1 more source

Host Factor Nucleophosmin 1 (NPM1/B23) Exerts Antiviral Effects against Chikungunya Virus by Its Interaction with Viral Nonstructural Protein 3

Microbiology Spectrum, 2023
Chikungunya virus (CHIKV) hijacks host cell machinery to support its replication. Nucleophosmin 1 (NPM1/B23), a nucleolar phosphoprotein, is one of the host proteins known to restrict CHIKV infection; however, the mechanistic details of the antiviral ...
Parvanendhu Pradeep, Krishnankutty Chandrika Sivakumar, Easwaran Sreekumar   +2 more
doaj   +1 more source

Evaluation of Midwife‐Led Colposcopy for Female Genital Schistosomiasis Screening at Primary Level of Care in Rural Madagascar: A Cross‐Sectional Study

Tropical Medicine &International Health, Volume 31, Issue 1, Page 49-57, January 2026.
ABSTRACT Introduction Female genital schistosomiasis is a condition with a complex diagnosis and severe consequences such as infertility. In the absence of a reliable biomarker, in endemic settings the World Health Organization recommends colposcopy as a diagnostic tool for the detection of female genital schistosomiasis lesions.
Pia Rausche, Jean‐Marc Kutz, Zoly Rakotomalala, Bodo Sahondra Randrianasolo, Paule Donven, Rivo Solotiana Rakotomalala, Alexina Olivasoa Tsiky Zafinimampera, Olivette Totofotsy, Sonya Ratefiarisoa, Ravo Razafindrakoto, Nantenaina Matthieu Razafindralava, Zaraniaina Tahiry Rasolojaona, Jana Hey, Aaron Remkes, Tahinamandranto Rasamoelina, Eva Lorenz, Rapahel Rakotozandrindrainy, Jürgen May, Monika Hampl, Irina Kislaya, Valentina Marchese, Rivo Andry Rakotoarivelo, Daniela Fusco   +22 more
wiley   +1 more source

Unscreened Polaron Ordering Against High Electron Density on Mechanically Cleaved Surfaces of WO3 (001) Films

Small, Volume 21, Issue 39, October 2, 2025.
Unscreened high‐density polarons are discovered in a metallic WO3 (001) 2DEG, stabilized by surface oxygen vacancies and c(2 × 2) reconstruction. ARPES and STM/STS reveal polaron formation and ordering, supported by first‐principles calculations. This work opens new avenues for exploring collective polaron phenomena, including bipolaron interactions ...
Gyubin Lee, Jeongdae Seo, Wooin Yang, Ji‐Ho Mun, Minho Kang, Ho‐Hyun Nahm, Yong‐Hyun Kim, Tae‐Hwan Kim, Chan‐Ho Yang, Yeongkwan Kim   +9 more
wiley   +1 more source

Calcium regulation of muscle spindle mechanosensory afferent function

Experimental Physiology, Volume 110, Issue 10, Page 1457-1472, October 1, 2025.
Abstract Extracellular calcium is crucial for the normal function of muscle spindle sensory afferents. They express multiple calcium buffering proteins. Extracellular calcium is essential for recycling of synaptic‐like vesicles (SLVs) in the terminals and for the stretch‐evoked inward calcium current of the receptor potential.
Anna Simon, Richard A. Lofthouse, Philip Miti, Claudiu V. Giuraniuc, Robert W. Banks, Guy S. Bewick   +5 more
wiley   +1 more source

Molecular Mechanisms of Extracellular Vesicle Biogenesis and Their Impact on the Design of Custom EVs

Advanced Healthcare Materials, Volume 14, Issue 23, September 8, 2025.
Extracellular vesicles (EVs) are pivotal mediators of intercellular communication and disease, yet the fundamental mechanisms controlling their biogenesis and cargo selection remain unclear. This limitation hinders their diagnostic utility and therapeutic development.
Luís Carvalho Ferraz, Paulo Pereira, João Vasco Ferreira   +2 more
wiley   +1 more source

PARP (Poly ADP‐ribose Polymerase) Family in Health and Disease

MedComm, Volume 6, Issue 9, September 2025.
PARP family orchestrates ADP‐ribosylation to regulate genomic stability (DNA repair, telomeres) and metabolism (NAD⁺, glucose/lipid). Physiological roles sustain health; dysregulation drives pathologies: cancer (DNA repair addiction), neurodegeneration (parthanatos), cardiovascular disorders (hypertrophy/fibrosis), inflammation (dual role), and viral ...
Pengyuan Lei, Wenfeng Li, Jinhua Luo, Nanxin Xu, Yahe Wang, Dafei Xie, Hua Guan, Bo Huang, Xin Huang, Pingkun Zhou   +9 more
wiley   +1 more source

Asymptotic Analysis of Stokes Flow Through a Filter

Mathematical Methods in the Applied Sciences, Volume 48, Issue 13, Page 12913-12934, September 2025.
ABSTRACT This paper investigates the Stokes flow through a thin porous layer composed of a rigid, thin, periodic, and closely packed array of parallel long rods with a noncircular, anisotropic cross‐section in the shape of a slot. This shape allows for the construction of a thicker permeable filter than what is known as the Brinkman critical size.
Georges Griso, Larysa Khilkova, Julia Orlik   +2 more
wiley   +1 more source

Reentrant Phenomenon in Barium Titanate Zirconate‐Based Relaxor Ferroelectrics

Small, Volume 21, Issue 35, September 4, 2025.
This study explores reentrant relaxor behavior in (1 − x)Ba(Ti0.85Zr0.15)O3‐xBi(Zn2/3Nb1/3)O3 (BTZr‐BZNb). Substituting with BZNb disrupts long‐range polar order, creating nanometer‐scale “antipolar clusters” within a polar matrix. The competition between polar modes and antiferrodistortive rotations leads to low‐temperature relaxor anomalies ...
Eva Kröll, Boriana Mihailova, Vadzim Haronin, Jūras Banys, Doru C. Lupascu, Vladimir V. Shvartsman   +5 more
wiley   +1 more source