Results 51 to 60 of about 4,884 (228)

Multiscale nature of hysteretic phenomena: Application to CoPt-type magnets [PDF]

, 2002
We suggest a workable approach for the description of multiscale magnetization reversal phenomena in nanoscale magnets and apply it to CoPt-type alloys. We show that their hysteretic properties are governed by two effects originating at different length ...
B. Zhang, B. Zhang, C. Leroux, H. Kronmüller, J. Fidler, K. D. Belashchenko, K.D. Belashchenko, L.-Q. Chen, M. Pratzer, N.I. Vlasova, R. Fischer, V. P. Antropov, Ya.S. Shur   +12 more
core   +3 more sources

Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential [PDF]

Open Biology, 2020
Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation.
Johannes Gregor Matthias Rack, Valentina Zorzini, Zihan Zhu, Marion Schuller, Dragana Ahel, Ivan Ahel   +5 more
doaj   +1 more source

Reversing ADP-ribosylation

eLife, 2017
The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
Giuliana Katharina Moeller, Gyula Timinszky   +1 more
doaj   +1 more source

Structure, function and inhibition of poly(ADP-ribose)polymerase, member 14 (PARP14) [PDF]

, 2018
Poly(ADP-ribose)polymerase, member 14 (PARP14, alternatively named ARTD8, BAL2, and COAST6) is an intracellular mono(ADP-ribosyl) transferase. PARP14 transfers a negatively charged ADP-ribose unit from a donor NAD+ molecule onto a target protein, post ...
Levonis, Stephan M, Schweiker, Stephanie S, Sherry, Madeleine, Tauber, Amanda   +3 more
core   +1 more source

To translate, or not to translate: viral and host mRNA regulation by interferon-stimulated genes. [PDF]

, 2015
Type I interferon (IFN) is one of the first lines of cellular defense against viral pathogens. As a result of IFN signaling, a wide array of IFN-stimulated gene (ISG) products is upregulated to target different stages of the viral life cycle.
Li, Melody MH, MacDonald, Margaret R, Rice, Charles M   +2 more
core   +1 more source

Chromosomal macrodomains and associated proteins: implications for DNA organization and replication in gram negative bacteria.

PLoS Genetics, 2011
The Escherichia coli chromosome is organized into four macrodomains, the function and organisation of which are poorly understood. In this review we focus on the MatP, SeqA, and SlmA proteins that have recently been identified as the first examples of ...
Remus T Dame, Olga J Kalmykowa, David C Grainger   +2 more
doaj   +1 more source

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking

Science Advances, 2020
Massive fragment screening effort provides a foundation for the development of macrodomain inhibitors as novel antiviral agents. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts ...
M. Schuller, G. Correy, Stefan Gahbauer, D. Fearon, Taia Wu, R. E. Díaz, I. Young, Luan Carvalho Martins, Dominique H. Smith, U. Schulze-Gahmen, T. Owens, I. Deshpande, G. Merz, A. Thwin, J. Biel, J. Peters, M. Moritz, N. Herrera, H. Kratochvil, A. Aimon, J. Bennett, J. Brandao Neto, A. Cohen, A. Dias, A. Douangamath, L. Dunnett, O. Fedorov, Matteo P. Ferla, M. Fuchs, T. Gorrie-Stone, J. Holton, Michael G. Johnson, T. Krojer, G. Meigs, A. Powell, J. Rack, V. Rangel, S. Russi, R. Skyner, Clyde A. Smith, A. Soares, J. Wierman, K. Zhu, Peter O’Brien, N. Jura, A. Ashworth, J. Irwin, M. Thompson, J. Gestwicki, F. von Delft, B. Shoichet, J. Fraser, I. Ahel   +52 more
semanticscholar   +1 more source

Macroscopic and mesoscopic matter waves [PDF]

, 2002
It has been shown earlier that matter waves which are known to lie typically in the range of a few Angstrom, can also manifest in the macrodomain with a wave length of a few centimeters, for electrons propagating along a magnetic field.
Varma, Ram K.
core   +2 more sources

Recognition of Mono-ADP-Ribosylated ARTD10 Substrates by ARTD8 Macrodomains [PDF]

Structure, 2013
ADP-ribosyltransferases (ARTs) catalyze the transfer of ADP-ribose from NAD(+) onto substrates. Some ARTs generate in an iterative process ADP-ribose polymers that serve as adaptors for distinct protein domains. Other ARTs, exemplified by ARTD10, function as mono-ADP-ribosyltransferases, but it has been unclear whether this modification occurs in cells
Forst, Alexandra H., Karlberg, Tobias, Herzog, Nicolas, Thorsell, Ann-Gerd, Gross, Annika, Feijs, Karla L.H., Verheugd, Patricia, Kursula, Petri, Nijmeijer, Bianca, Kremmer, Elisabeth, Kleine, Henning, Ladurner, Andreas G., Schüler, Herwig, Lüscher, Bernhard   +13 more
openaire   +3 more sources

Structure of the sirtuin‐linked macrodomain SAV0325 from Staphylococcus aureus [PDF]

Protein Science, 2016
AbstractCells use the post‐translational modification ADP‐ribosylation to control a host of biological activities. In some pathogenic bacteria, an operon‐encoded mono‐ADP‐ribosylation cycle mediates response to host‐induced oxidative stress. In this system, reversible mono ADP‐ribosylation of a lipoylated target protein represses oxidative stress ...
Appel, C. Denise, Feld, Geoffrey K., Wallace, Bret D., Williams, R. Scott   +3 more
openaire   +2 more sources