Results 51 to 60 of about 1,793 (163)

Chromosome structuring limits genome plasticity in Escherichia coli. [PDF]

PLoS Genetics, 2007
Chromosome organizations of related bacterial genera are well conserved despite a very long divergence period. We have assessed the forces limiting bacterial genome plasticity in Escherichia coli by measuring the respective effect of altering different ...
Emilie Esnault, Michèle Valens, Olivier Espéli, Frédéric Boccard   +3 more
doaj   +1 more source

Antiviral activity of myricetin glycosylated compounds isolated from Marcetia taxifolia against chikungunya virus

EXCLI Journal : Experimental and Clinical Sciences, 2023
The chikungunya virus (CHIKV) has produced epidemic outbreaks of significant public health impact. The clinical symptoms of this disease are fever, polyarthralgia, and skin rash, generally self-limiting, although patients may develop a chronic disabling ...
Ana Luisa Muñoz, Andrés Felipe Cuéllar, Gabriela Arévalo, Brian David Santamaría, Anny K. Rodríguez, Cristian Buendía-Atencio, Andrés Reyes Chaparro, Aldo Yair Tenorio Barajas, Nydia Alexandra Segura, Felio Bello, Alírica Suárez, Hector R. Rangel, Mónica Losada-Barragán   +12 more
doaj   +1 more source

Record Energy Storage Performance Metrics in Ferroelectric Hafnia‐Based Films through Heterostructure Design

Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.
Dielectric capacitors typically struggle to achieve both high energy storage density and high efficiency at applied voltages below 10 V. Here, we address this challenge by introducing a novel hybrid fluorite/perovskite heterostructure design that combines ultra‐high recoverable energy storage density with efficient energy release (Uf ≈ 1016 J/cm3), at ...
Ampattu R. Jayakrishnan, Nuno Estrócio, Inês Silva, Raluca Negrea, Marian C. Istrate, Koppole C. Sekhar, Luís Marques, Judith L. MacManus‐Driscoll, Ignasi Fina, Florencio Sánchez, José P. B. Silva   +10 more
wiley   +1 more source

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression.

PLoS Pathogens, 2019
ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs.
Matthew E Grunewald, Yating Chen, Chad Kuny, Takashi Maejima, Robert Lease, Dana Ferraris, Masanori Aikawa, Christopher S Sullivan, Stanley Perlman, Anthony R Fehr   +9 more
doaj   +1 more source

Long range chromosome organization in Escherichia coli: The position of the replication origin defines the non-structured regions and the Right and Left macrodomains. [PDF]

PLoS Genetics, 2017
The Escherichia coli chromosome is organized into four macrodomains (Ori, Ter, Right and Left) and two non-structured regions. This organization influences the segregation of sister chromatids, the mobility of chromosomal DNA, and the cellular ...
Stéphane Duigou, Frédéric Boccard
doaj   +1 more source

SARS‐CoV‐2 Variants and Immune Evasion: Mapping the Future of Vaccine Design

Reviews in Medical Virology, Volume 36, Issue 3, May 2026.
ABSTRACT The evolutionary trajectory of Severe Acute Respiratory Syndrome Coronavirus 2 (SARS‐CoV‐2) has progressed through several distinct phases since its zoonotic emergence, transitioning from initial human adaptation to an era of rapid antigenic drift and complex immune evasion. As of early 2026, the global landscape is dominated by highly evolved
Fatih Uzer, Fulya Erendor, Salih Sanlioglu   +2 more
wiley   +1 more source

Roles for replichores and macrodomains in segregation of the Escherichia coli chromosome [PDF]

EMBO reports, 2005
Recent work has highlighted two main levels of global organization of the Escherichia coli chromosome. Macrodomains are large domains inferred from structural data consisting of loci showing the same intracellular positioning.
Christian, Lesterlin, Romain, Mercier, Frédéric, Boccard, François-Xavier, Barre, François, Cornet   +4 more
openaire   +2 more sources

Multiorgan Molecular Landscape of Severe COVID‐19 Revealed by Consensus Gene Signatures and RAB8B Targeting

Journal of Medical Virology, Volume 98, Issue 4, April 2026.
ABSTRACT Severe COVID‐19 involves hyperinflammation and multiorgan pathology, but consistent gene signatures remain elusive. We aimed to identify consensus transcriptomic signatures and molecular mechanisms in severe COVID‐19. We performed an integrative analysis of 39 studies spanning 11 tissue types, 1551 bulk RNA‐seq samples, and over 2 million ...
Jonathan Peña Avila, Peter Park, Youvika Singh, Paulo P. Amaral, Ícaro Castro, Felipe Ten‐Caten, Viviane Schuch, André N. A. Gonçalves, Jeevan Giddaluru, Mauro César Cafundó Morais, Rodrigo L. T. Ogava, Thiago Lubiana, Gabriel Amoroso de Castro, Rodrigo Aquino, Luiz Durão, Júlia Raspante Martins, Leandro Jimenez, André G. Costa‐Martins, Patrícia Gonzalez‐Dias, Thiago Dominguez Crespo Hirata, Thomaz Lüscher Dias, Débora Guerra Peixe, Adriana Simizo, Juan Carlo Santos e Silva, Amanda Pereira Vasconcelos, Marcelo Berçot Rodrigues, Bianca G. Castelucci, João Victor Virgillio‐da‐Silva, Larissa Menezes, Pedro M. Moraes‐Vieira, Otavio Cabral‐Marques, Helder I. Nakaya   +31 more
wiley   +1 more source

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis [PDF]

Journal of Virology, 2015
ABSTRACT All coronaviruses encode a macrodomain containing ADP-ribose-1″-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type virus but was unable to cause ...
Anthony R, Fehr, Jeremiah, Athmer, Rudragouda, Channappanavar, Judith M, Phillips, David K, Meyerholz, Stanley, Perlman   +5 more
openaire   +2 more sources

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

Nature Communications
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das   +8 more
doaj   +1 more source