Results 51 to 60 of about 1,800 (162)

A family of macrodomain proteins reverses cellular mono-ADP-ribosylation [PDF]

Nature Structural & Molecular Biology, 2013
ADP-ribosylation is a reversible post-translational modification with wide-ranging biological functions in all kingdoms of life. A variety of enzymes use NAD(+) to transfer either single or multiple ADP-ribose (ADPr) moieties onto distinct amino acid substrates, often in response to DNA damage or other stresses.
Jankevicius, Gytis, Hassler, Markus, Golia, Barbara, Rybin, Vladimir, Zacharias, Martin, Timinszky, Gyula, Ladurner, Andreas G   +6 more
openaire   +2 more sources

Chromosome structuring limits genome plasticity in Escherichia coli. [PDF]

PLoS Genetics, 2007
Chromosome organizations of related bacterial genera are well conserved despite a very long divergence period. We have assessed the forces limiting bacterial genome plasticity in Escherichia coli by measuring the respective effect of altering different ...
Emilie Esnault, Michèle Valens, Olivier Espéli, Frédéric Boccard   +3 more
doaj   +1 more source

Antiviral activity of myricetin glycosylated compounds isolated from Marcetia taxifolia against chikungunya virus

EXCLI Journal : Experimental and Clinical Sciences, 2023
The chikungunya virus (CHIKV) has produced epidemic outbreaks of significant public health impact. The clinical symptoms of this disease are fever, polyarthralgia, and skin rash, generally self-limiting, although patients may develop a chronic disabling ...
Ana Luisa Muñoz, Andrés Felipe Cuéllar, Gabriela Arévalo, Brian David Santamaría, Anny K. Rodríguez, Cristian Buendía-Atencio, Andrés Reyes Chaparro, Aldo Yair Tenorio Barajas, Nydia Alexandra Segura, Felio Bello, Alírica Suárez, Hector R. Rangel, Mónica Losada-Barragán   +12 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Characterization of Brucella abortus lipopolysaccharide macrodomains as mega rafts

Cellular Microbiology, 2006
The lipopolysaccharides (LPS) of intracellular Proteobacteria such as Brucella, Chlamydia, Legionella and Rickettsia, have properties distinct from enterobacterial LPSs. These properties include deficient LPS induction of host cell activation, low endotoxicity and resistance to macrophage degradation.
Lapaque, N., Forquet, F., de Chastellier, C., Mishal, Z., Jolly, G., Moreno, E., Moriyon, I., Heuser, J.E., He, H.T., Gorvel, J.P.   +9 more
openaire   +5 more sources

Long range chromosome organization in Escherichia coli: The position of the replication origin defines the non-structured regions and the Right and Left macrodomains. [PDF]

PLoS Genetics, 2017
The Escherichia coli chromosome is organized into four macrodomains (Ori, Ter, Right and Left) and two non-structured regions. This organization influences the segregation of sister chromatids, the mobility of chromosomal DNA, and the cellular ...
Stéphane Duigou, Frédéric Boccard
doaj   +1 more source

Thermally Induced Evolution of the Local Structural Behavior in BiFeO3‐BaTiO3‐Based Ceramics

Journal of the American Ceramic Society, Volume 109, Issue 7, July 2026.
ABSTRACT The environmental urgency to replace toxic lead‐based piezoelectrics like Pb(Zr,Ti)O3 has driven the development of lead‐free alternatives such as BiFeO3–BaTiO3 ceramics. While macroscopic structural optimization has yielded promising electrostrain performance, the role of the local structure remains underexplored.
Hareem Zubairi, Mustapha Zaghrioui, Mingchen Gong, Anna Katharina Ott, Khalid Ait Ali, Fabien Giovannelli, Guillaume F. Nataf, Ge Wang   +7 more
wiley   +1 more source

Record Energy Storage Performance Metrics in Ferroelectric Hafnia‐Based Films through Heterostructure Design

Advanced Functional Materials, Volume 36, Issue 44, 1 June 2026.
Dielectric capacitors typically struggle to achieve both high energy storage density and high efficiency at applied voltages below 10 V. Here, we address this challenge by introducing a novel hybrid fluorite/perovskite heterostructure design that combines ultra‐high recoverable energy storage density with efficient energy release (Uf ≈ 1016 J/cm3), at ...
Ampattu R. Jayakrishnan, Nuno Estrócio, Inês Silva, Raluca Negrea, Marian C. Istrate, Koppole C. Sekhar, Luís Marques, Judith L. MacManus‐Driscoll, Ignasi Fina, Florencio Sánchez, José P. B. Silva   +10 more
wiley   +1 more source

The nsp3 Macrodomain Promotes Virulence in Mice with Coronavirus-Induced Encephalitis [PDF]

Journal of Virology, 2015
ABSTRACT All coronaviruses encode a macrodomain containing ADP-ribose-1″-phosphatase (ADRP) activity within the N terminus of nonstructural protein 3 (nsp3). Previous work showed that mouse hepatitis virus strain A59 (MHV-A59) with a mutated catalytic site (N1348A) replicated similarly to wild-type virus but was unable to cause ...
Anthony R, Fehr, Jeremiah, Athmer, Rudragouda, Channappanavar, Judith M, Phillips, David K, Meyerholz, Stanley, Perlman   +5 more
openaire   +2 more sources

Recombinant infectious bronchitis virus containing mutations in non-structural proteins 10, 14, 15, and 16 and within the macrodomain provides complete protection against homologous challenge

Journal of Virology
Infectious bronchitis virus (IBV) is the etiological agent of infectious bronchitis, an acute highly contagious economically important disease of chickens.
Sarah Keep, Katalin Foldes, Guilia Dowgier, Graham Freimanis, Chandana Tennakoon, Shafiyeel Chowdhury, Adam Rayment, James Kirk, Trinity Bakshi, Phoebe Stevenson-Leggett, Yana Chen, Paul Britton, Erica Bickerton   +12 more
doaj   +1 more source