Results 31 to 40 of about 2,256 (152)
eLife, 2017 The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
Giuliana Katharina Moeller +1 more
doaj +1 more source
Viral macrodomains: a structural and evolutionary assessment of the pharmacological potential [PDF]
Open Biology, 2020 Viral macrodomains possess the ability to counteract host ADP-ribosylation, a post-translational modification implicated in the creation of an antiviral environment via immune response regulation.
Johannes Gregor Matthias Rack +5 more
doaj +1 more source
Investigating strategies to modify PARP14 function through macrodomain inhibition [PDF]
, 2017 Macrodomains are conserved protein interaction modules that are present in all domains of life and mediate recognition of sequence motifs harbouring adenosine diphosphate ribose (ADPR) modifications.
Schuller, Marion, Marion Schuller
core +1 more source
mBio, 2020 Macrodomain (MD), a highly conserved protein fold present in a subset of plus-strand RNA viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins.
Rachy Abraham +5 more
doaj +1 more source
Frontiers in Microbiology, 2023 Topoisomerase IV (Topo IV) is the main decatenation enzyme in Escherichia coli; it removes catenation links that are formed during DNA replication. Topo IV binding and cleavage sites were previously identified in the E.
Dmitry Sutormin +3 more
doaj +1 more source
Pharmaceuticals, 2022 Macrodomain-I of the NSP3 (non-structural protein 3) is responsible for immune response hijacking in the SARS-CoV-2 infection known as COVID-19. In the omicron variant (B.1.1.529), this domain harbors a new mutation, V1069I, which may increase the ...
Ziad Tareq Naman +4 more
doaj +1 more source
Dielectric behavior and phase transition in [111]-oriented PIN–PMN–PT single crystals under dc bias [PDF]
Journal of Advanced Dielectrics, 2014 Temperature and electric field dependences of the dielectric behavior and phase transition for [111]-oriented 0.23PIN–0.52PMN–0.25PT (PIN-PMN–0.25PT) and 0.24PIN–0.43PMN–0.33PT (PIN–PMN–0.33PT) single crystals were investigated over a temperature range ...
Yuhui Wan +6 more
doaj +1 more source
Serine ADP-ribosylation reversal by the hydrolase ARH3
eLife, 2017 ADP-ribosylation (ADPr) is a posttranslational modification (PTM) of proteins that controls many cellular processes, including DNA repair, transcription, chromatin regulation and mitosis. A number of proteins catalyse the transfer and hydrolysis of ADPr,
Pietro Fontana +5 more
doaj +1 more source
SARS-CoV-2 nsP3 Macrodomain Characterization and Inhibitor Screening
, 2021 Viral macrodomains have mono-ADP-ribose hydrolytic activity, which can reverse the cellular post-translational modification mediated by different poly(ADP-ribose) polymerases (PARPs) that can attach a single ADP-ribose molecule or poly(ADP-ribose) chain ...
Zhuo, Junlin
core
A macrodomain-containing histone rearranges chromatin upon sensing PARP1 activation
, 2009 Poly-ADP-ribosylation is a post-translational modification catalyzed by PARP enzymes with roles in transcription and chromatin biology. Here we show that distinct macrodomains, including those of histone macroH2A1.1, are recruited to sites of PARP1 ...
Kustatscher, G +23 more
core +1 more source