Results 31 to 40 of about 4,884 (228)
HTRF-based assay for detection of mono-ADP-ribosyl hydrolyzing macrodomains and inhibitor screening [PDF]
iScienceSummary: The COVID-19 pandemic has highlighted the lack of effective, ready-to-use antivirals for the treatment of viruses with pandemic potential. The development of a diverse drug portfolio is therefore crucial for pandemic preparedness.
Niklas Ildefeld +3 more
doaj +2 more sources
Macrodomains: Structure, Function, Evolution, and Catalytic Activities [PDF]
Annual Review of Biochemistry, 2016 Recent developments indicate that macrodomains, an ancient and diverse protein domain family, are key players in the recognition, interpretation, and turnover of ADP-ribose (ADPr) signaling. Crucial to this is the ability of macrodomains to recognize ADPr either directly, in the form of a metabolic derivative, or as a modification covalently bound to ...
Johannes Gregor Matthias Rack +2 more
+5 more sources
Macrodomain ADP-ribosylhydrolase and the pathogenesis of infectious diseases. [PDF]
PLoS Pathogens, 2018 Anthony K L Leung +2 more
doaj +4 more sources
Macrodomain Binding Compound MRS 2578 Inhibits Alphavirus Replication
Antimicrobial Agents and Chemotherapy, 2021 Alphaviruses are positive-strand RNA viruses causing febrile disease. Macrodomain-containing proteins, involved in ADP-ribose-mediated signaling, are encoded by both host cells and several virus groups, including alphaviruses.
Sari Mattila +8 more
openaire +4 more sources
PARG: A Macrodomain in Disguise [PDF]
Structure, 2011 Our understanding of poly-ADP-ribosylation as a posttranslational modification was limited by the lack of structural information on poly-ADP-ribose (PAR) hydrolysing enzymes. A recent study in Nature (Slade et al., 2011) reports the structure of PAR glycohydrolase (PARG), revealing unexpected similarity to the ubiquitous ADP-ribose-binding macrodomains.
Markus Hassler +2 more
openaire +2 more sources
Viruses, 2023 Since the emergence of SARS-CoV-2, many genetic variations within its genome have been identified, but only a few mutations have been found in nonstructural proteins (NSPs).
Behnaz Yazdani +3 more
doaj +1 more source
Molecular docking study and molecular dynamics simulation of spice metabolites against main protease enzymes and NSP3 macrodomain SARS CoV-2 [PDF]
Pharmaciana, 2022 COVID-19 is still a global pandemic. The transmission is very fast and wide. Its prevalence continues to increase. There is no specific antiviral drug for SARS CoV 2 yet.
Purwaniati Purwaniati, Asep Roni
doaj +1 more source
Pathogens, 2023 Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar +3 more
doaj +1 more source
Spatial arrangement and macrodomain organization of bacterial chromosomes [PDF]
Molecular Microbiology, 2005 SummaryRecent developments in fluorescence microscopy have shown that bacterial chromosomes have a defined spatial arrangement that preserves the linear order of genes on the genetic map. These approaches also revealed that large portions of the chromosome in Escherichia coli or Bacillus subtilis are concentrated in the same cellular space, suggesting ...
Frédéric, Boccard +2 more
openaire +2 more sources
bioRxiv, 2022 The nonstructural protein 3 (NSP3) of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) contains a conserved macrodomain enzyme (Mac1) that is critical for pathogenesis and lethality.
Stefan Gahbauer +22 more
semanticscholar +1 more source