Results 31 to 40 of about 1,800 (162)

Host ADP-ribosylation and the SARS-CoV-2 macrodomain [PDF]

Biochemical Society Transactions, 2021
The COVID-19 pandemic has prompted intense research efforts into elucidating mechanisms of coronavirus pathogenesis and to propose antiviral interventions. The interferon (IFN) response is the main antiviral component of human innate immunity and is actively suppressed by several non-structural SARS-CoV-2 proteins, allowing viral replication within ...
openaire   +2 more sources

Roles for replichores and macrodomains in segregation of the Escherichia coli chromosome [PDF]

The EMBO Reports, 2005
Recent work has highlighted two main levels of global organization of the Escherichia coli chromosome. Macrodomains are large domains inferred from structural data consisting of loci showing the same intracellular positioning. Replichores, defined by base composition skews, coincide with the replication arms in normal cells.
Christian, Lesterlin, Romain, Mercier, Frédéric, Boccard, François-Xavier, Barre, François, Cornet   +4 more
openaire   +2 more sources

Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication

Journal of Virology, 2021
In the wake of the COVID-19 epidemic, there has been a surge to better understand how CoVs replicate and to identify potential therapeutic targets that could mitigate disease caused by SARS-CoV-2 and other prominent CoVs. The highly conserved macrodomain, also termed Mac1, is a small domain within nonstructural protein 3.
Lynden S. Voth, Joseph J. O’Connor, Catherine M. Kerr, Ethan Doerger, Nancy Schwarting, Parker Sperstad, David K. Johnson, Anthony R. Fehr   +7 more
openaire   +3 more sources

IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?

Pathogens, 2023
Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids
Katharina Biaesch, Sarah Knapp, Patricia Korn   +2 more
doaj   +1 more source

An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors

Pathogens, 2023
Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose binding
Joseph J. O’Connor, Dana Ferraris, Anthony R. Fehr   +2 more
doaj   +1 more source

Reversing ADP-ribosylation

eLife, 2017
The modification of serines by molecules of ADP-ribose plays an important role in signaling that the DNA in a cell has been damaged and needs to be repaired.
Giuliana Katharina Moeller, Gyula Timinszky   +1 more
doaj   +1 more source

Crystal structure and biochemical activity of the macrodomain from rubella virus p150 [PDF]

Journal of Virology
Christopher Douse, Yorgo Modis
exaly   +2 more sources

Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice

mBio, 2020
Macrodomain (MD), a highly conserved protein fold present in a subset of plus-strand RNA viruses, binds to and hydrolyzes ADP-ribose (ADPr) from ADP-ribosylated proteins.
Rachy Abraham, Robert L. McPherson, Morgan Dasovich, Mohsen Badiee, Anthony K. L. Leung, Diane E. Griffin   +5 more
doaj   +1 more source

Chromosomal macrodomains and associated proteins: implications for DNA organization and replication in gram negative bacteria.

PLoS Genetics, 2011
The Escherichia coli chromosome is organized into four macrodomains, the function and organisation of which are poorly understood. In this review we focus on the MatP, SeqA, and SlmA proteins that have recently been identified as the first examples of ...
Remus T Dame, Olga J Kalmykowa, David C Grainger   +2 more
doaj   +1 more source

Correction to "A Fluorescence Polarization Assay for Macrodomains Facilitates the Identification of Potent Inhibitors of the SARS-CoV-2 Macrodomain". [PDF]

ACS Chem Biol
Anmangandla A, Jana S, Peng K, Wallace SD, Bagde SR, Drown BS, Xu J, Hergenrother PJ, Fromme JC, Lin H.   +9 more
europepmc   +2 more sources