Results 11 to 20 of about 2,256 (152)

Chromosomal macrodomains and associated proteins: implications for DNA organization and replication in gram negative bacteria. [PDF]

PLoS Genetics, 2011
The Escherichia coli chromosome is organized into four macrodomains, the function and organisation of which are poorly understood. In this review we focus on the MatP, SeqA, and SlmA proteins that have recently been identified as the first examples of ...
Remus T Dame, Olga J Kalmykowa, David C Grainger   +2 more
doaj   +2 more sources

The Conserved Coronavirus Macrodomain Promotes Virulence and Suppresses the Innate Immune Response during Severe Acute Respiratory Syndrome Coronavirus Infection [PDF]

mBio, 2016
ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets.
Anthony R. Fehr, Rudragouda Channappanavar, Gytis Jankevicius, Craig Fett, Jincun Zhao, Jeremiah Athmer, David K. Meyerholz, Ivan Ahel, Stanley Perlman   +8 more
doaj   +2 more sources

Molecular docking study and molecular dynamics simulation of spice metabolites against main protease enzymes and NSP3 macrodomain SARS CoV-2 [PDF]

Pharmaciana, 2022
COVID-19 is still a global pandemic. The transmission is very fast and wide. Its prevalence continues to increase. There is no specific antiviral drug for SARS CoV 2 yet.
Purwaniati Purwaniati, Asep Roni
doaj   +3 more sources

The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression. [PDF]

PLoS Pathogens, 2019
ADP-ribosylation is a ubiquitous post-translational addition of either monomers or polymers of ADP-ribose to target proteins by ADP-ribosyltransferases, usually by interferon-inducible diphtheria toxin-like enzymes known as PARPs.
Matthew E Grunewald, Yating Chen, Chad Kuny, Takashi Maejima, Robert Lease, Dana Ferraris, Masanori Aikawa, Christopher S Sullivan, Stanley Perlman, Anthony R Fehr   +9 more
doaj   +2 more sources

Family-wide analysis of human macrodomains reveals novel activities and identifies PARG as most efficient ADPr-RNA hydrolase [PDF]

Communications Biology
ADP-ribosylation is well-known as protein posttranslational modification and was recently also identified as RNA posttranscriptional modification. When macrodomain proteins were identified as protein ADP-ribosylhydrolases, several ADP-ribosylation ...
Lisa Weixler, Roko Žaja, Nonso J. Ikenga, Jonas Siefert, Ganga Mohan, Gülcan Aydin, Sven Wijngaarden, Dmitri V. Filippov, Bernhard Lüscher, Karla L. H. Feijs-Žaja   +9 more
doaj   +2 more sources

Cell type-dependent induction of type I interferon and PARP1 activation in astrocytes and neurons during chikungunya virus infection [PDF]

Microbiology Spectrum
Chikungunya virus, a mosquito-borne alphavirus, causes fever, rash, arthritis, and neurological disorders. Its non-structural protein 3 harbors a macrodomain, a key neurovirulence factor that removes adenosine diphosphate ribose from ADP-ribosylated ...
Lisa Pieterse, Taewoo Kim, Che-Yuan Chang, Ilsa T. Kirby, Benjamin H. Nguyen, Larissa Cortes Morales, Rodney Eric Williams, Easwaran Sreekumar, Michael S. Cohen, Anthony K. L. Leung, Diane E. Griffin, Rachy Abraham   +11 more
doaj   +2 more sources

Structure-Based Rational Design of a Selective Hydrolase Inhibitor of the Severe Acute Respiratory Syndrome Coronavirus-2 Nsp3 Macrodomain. [PDF]

Chembiochem
Structure‐guided design of a sulfamoyl‐modified analog of GS‐441524 yielded a selective, high‐affinity inhibitor of the SARS‐CoV‐2 macrodomain Nsp3b. The compound occupies the phosphate‐binding pocket, forming a stabilizing hydrogen‐bond network that enhances binding affinity (K_D = 0.86 μM).
Krishnathas R, Mineev KS, Fourkiotis NK, Touret F, Sideras-Bisdekis C, Tsika AC, Gande SL, Linhard V, Sreeramulu S, Lennartz F, Weiss MS, Coutard B, Spyroulias GA, Schwalbe H.   +13 more
europepmc   +2 more sources

Fragment binding to the Nsp3 macrodomain of SARS-CoV-2 identified through crystallographic screening and computational docking [PDF]

, 2021
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) macrodomain within the nonstructural protein 3 counteracts host-mediated antiviral adenosine diphosphate-ribosylation signaling.
Fraser, James S, Ahel, Ivan, Thompson, Michael C   +2 more
core   +4 more sources

Structure-Based High-Throughput Virtual Screening and Molecular Dynamics Simulation for the Discovery of Novel SARS-CoV-2 NSP3 Mac1 Domain Inhibitors

Viruses, 2023
Since the emergence of SARS-CoV-2, many genetic variations within its genome have been identified, but only a few mutations have been found in nonstructural proteins (NSPs).
Behnaz Yazdani, Hajar Sirous, Simone Brogi, Vincenzo Calderone   +3 more
doaj   +1 more source

ADP-ribosylation: An emerging regulator of the epigenome. [PDF]

Mol Oncol
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Camacho CV, Liu C, Kraus WL.
europepmc   +2 more sources