Results 21 to 30 of about 1,793 (163)
Spatial arrangement and macrodomain organization of bacterial chromosomes [PDF]
Molecular Microbiology, 2005 SummaryRecent developments in fluorescence microscopy have shown that bacterial chromosomes have a defined spatial arrangement that preserves the linear order of genes on the genetic map. These approaches also revealed that large portions of the chromosome in Escherichia coli or Bacillus subtilis are concentrated in the same cellular space, suggesting ...
Frédéric, Boccard +2 more
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The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase [PDF]
Journal of Virology, 2020 ABSTRACT Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and other SARS-like-CoVs encode 3 tandem macrodomains within non-structural protein 3 (nsp3). The first macrodomain, Mac1, is conserved throughout CoVs, and binds to and hydrolyzes mono-ADP-ribose (MAR) from target proteins.
Yousef M.O. Alhammad +12 more
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Pathogens, 2023 Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar +3 more
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Design, Synthesis and Evaluation of Inhibitors of the SARS-CoV2 nsp3 Macrodomain [PDF]
Bioorganic & Medicinal Chemistry, 2022 Abstract A series of amino acid based 7H -pyrrolo[2,3- d ]pyrimidines were designed and synthesized to discern the structure activity relationships against the SARS-CoV-2 nsp3 macrodomain (Mac1), an ADP-ribosylhydrolase that is critical for ...
Lavinia M. Sherrill +14 more
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Characterization of a Distinct Plasma Membrane Macrodomain in Differentiated Adipocytes [PDF]
Journal of Biological Chemistry, 2002 Caveolae are small invaginations of the cell surface that are abundant in mature adipocytes. A recent study (Kanzaki, M., and Pessin, J. E. (2002) J. Biol. Chem. 277, 25867-25869) described novel caveolin- and actin-containing structures associated with the adipocyte cell surface that contain specific signaling proteins.
Parton, R. G. +4 more
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Viruses, 2022 Chikungunya virus (CHIKV) causes outbreaks of rash, arthritis, and fever associated with neurologic complications, where astrocytes are preferentially infected.
Taewoo Kim +4 more
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Viral Macrodomains: Unique Mediators of Viral Replication and Pathogenesis [PDF]
Trends in Microbiology, 2018 Viruses from the Coronaviridae, Togaviridae, and Hepeviridae families all contain genes that encode a conserved protein domain, called a macrodomain; however, the role of this domain during infection has remained enigmatic. The recent discovery that mammalian macrodomain proteins enzymatically remove ADP-ribose, a common post-translation modification,
Fehr, A +3 more
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mBio, 2016 ADP-ribosylation is a common posttranslational modification that may have antiviral properties and impact innate immunity. To regulate this activity, macrodomain proteins enzymatically remove covalently attached ADP-ribose from protein targets.
Anthony R. Fehr +8 more
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Evidence for divisome localization mechanisms independent of the Min system and SlmA in Escherichia coli. [PDF]
PLoS Genetics, 2014 Cell division in Escherichia coli starts with assembly of FtsZ protofilaments into a ring-like structure, the Z-ring. Positioning of the Z-ring at midcell is thought to be coordinated by two regulatory systems, nucleoid occlusion and the Min system. In E.
Matthew W Bailey +4 more
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Host ADP-ribosylation and the SARS-CoV-2 macrodomain [PDF]
Biochemical Society Transactions, 2021 The COVID-19 pandemic has prompted intense research efforts into elucidating mechanisms of coronavirus pathogenesis and to propose antiviral interventions. The interferon (IFN) response is the main antiviral component of human innate immunity and is actively suppressed by several non-structural SARS-CoV-2 proteins, allowing viral replication within ...
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