Results 21 to 30 of about 2,256 (152)
High-Throughput Activity Assay for Screening Inhibitors of the SARS-CoV2 Mac1 Macrodomain
, 2022 Macrodomains are a class of conserved ADP-ribosylhydrolases expressed by viruses of pandemic concern, including coronaviruses and alphaviruses. Viral macrodomains are critical for replication and virus-induced pathogenesis; therefore, these enzymes are a
Takashi Tsukamoto +33 more
core +3 more sources
Pathogens, 2023 Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar +3 more
doaj +1 more source
Viruses, 2022 Chikungunya virus (CHIKV) causes outbreaks of rash, arthritis, and fever associated with neurologic complications, where astrocytes are preferentially infected.
Taewoo Kim +4 more
doaj +1 more source
The MatP/matS Site-Specific System Organizes the Terminus Region of the E. coli Chromosome into a Macrodomain [PDF]
, 2008 The organization of the Escherichia coli chromosome into insulated macrodomains influences the segregation of sister chromatids and the mobility of chromosomal DNA.
El Karoui, Meriem +7 more
core +1 more source
Evidence for divisome localization mechanisms independent of the Min system and SlmA in Escherichia coli. [PDF]
PLoS Genetics, 2014 Cell division in Escherichia coli starts with assembly of FtsZ protofilaments into a ring-like structure, the Z-ring. Positioning of the Z-ring at midcell is thought to be coordinated by two regulatory systems, nucleoid occlusion and the Min system. In E.
Matthew W Bailey +4 more
doaj +1 more source
Emerging Concepts on the Role of ADP-Ribosylation
Challenges, 2020 NAD+ has emerged as a crucial element in both bioenergetic and signaling pathways, since it acts as a key regulator of cellular and organism homeostasis.
Palmiro Poltronieri
doaj +1 more source
Crystal structures of SARS-CoV-2 ADP-ribose phosphatase: from the apo form to ligand complexes
IUCrJ, 2020 Among 15 nonstructural proteins (Nsps), the newly emerging Severe Acute Respiratory Syndrome coronavirus 2 (SARS-CoV-2) encodes a large, multidomain Nsp3. One of its units is the ADP-ribose phosphatase domain (ADRP; also known as the macrodomain, MacroD),
Karolina Michalska +6 more
doaj +1 more source
Structure of macrodomain walls in polytwinned magnets [PDF]
, 2002 We propose a microscopic approach to the studies of magnetic configurations in hard magnets which may be conveniently used for nanoscale systems; the microstructure of the magnet is easily and naturally included in the calculations.
K. D. Belashchenko +3 more
core +1 more source
IFN-Induced PARPs—Sensors of Foreign Nucleic Acids?
Pathogens, 2023 Cells have developed different strategies to cope with viral infections. Key to initiating a defense response against viruses is the ability to distinguish foreign molecules from their own. One central mechanism is the perception of foreign nucleic acids
Katharina Biaesch +2 more
doaj +1 more source
An Update on the Current State of SARS-CoV-2 Mac1 Inhibitors
Pathogens, 2023 Non-structural protein 3 (nsp3) from all coronaviruses (CoVs) contains a conserved macrodomain, known as Mac1, that has been proposed as a potential therapeutic target for CoVs due to its critical role in viral pathogenesis. Mac1 is an ADP-ribose binding
Joseph J. O’Connor +2 more
doaj +1 more source