Results 11 to 20 of about 214,575 (242)
Reversible ADP-ribosylation of RNA [PDF]
Nucleic Acids Research, 2019 ADP-ribosylation is a reversible chemical modification catalysed by ADP-ribosyltransferases such as PARPs that utilize nicotinamide adenine dinucleotide (NAD+) as a cofactor to transfer monomer or polymers of ADP-ribose nucleotide onto macromolecular ...
D. Munnur +7 more
semanticscholar +6 more sources
ADP-Ribosylation in Antiviral Innate Immune Response
Pathogens, 2023 Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to the target substrate and release ...
Qian Du, Ying Miao, Wei He, Hui Zheng
doaj +2 more sources
ADP-ribosylation from molecular mechanisms to therapeutic implications
Cell, 2023 Summary ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life.
M. Suskiewicz +3 more
semanticscholar +2 more sources
ADP-ribosylation of DNA and RNA
DNA Repair, 2021 ADP-ribosylation is a chemical modification of macromolecules found across all domains of life and known to regulate a variety of cellular processes. Notably, it has a well-established role in the DNA damage response. While it was historically known as a
Joséphine Groslambert +2 more
semanticscholar +3 more sources
ADP-Ribosylation of Cytidine: A Novel Nucleic Acid Modification Reversed by NADAR Hydrolases [PDF]
ToxinsADP-ribosylation of nucleic acids is a modification found in both eukaryotes and bacteria, where it contributes to genome maintenance but can also serve as a toxic mechanism used by bacterial toxins to disrupt essential cellular processes.
Petra Mikolčević +6 more
doaj +2 more sources
Ribosome ADP-ribosylation inhibits translation and maintains proteostasis in cancers
Cell, 2021 Summary Defects in translation lead to changes in the expression of proteins that can serve as drivers of cancer formation. Here, we show that cytosolic NAD+ synthesis plays an essential role in ovarian cancer by regulating translation and maintaining ...
Sridevi Challa +2 more
exaly +2 more sources
An HPF1/PARP1-Based Chemical Biology Strategy for Exploring ADP-Ribosylation
Cell, 2020 Strategies for installing authentic ADP-ribosylation (ADPr) at desired positions are fundamental for creating the tools needed to explore this elusive post-translational modification (PTM) in essential cellular processes.
Juan JOSÉ Bonfiglio +2 more
exaly +2 more sources
PARP14 is regulated by the PARP9/DTX3L complex and promotes interferon γ-induced ADP-ribosylation
The EMBO JournalProtein ADP-ribosylation plays important but ill-defined roles in antiviral signalling cascades such as the interferon response. Several viruses of clinical interest, including coronaviruses, express hydrolases that reverse ADP-ribosylation catalysed by ...
Victoria Chaves Ribeiro +2 more
doaj +2 more sources
Beyond protein modification: the rise of non-canonical ADP-ribosylation
Biochemical Journal, 2022 ADP-ribosylation has primarily been known as post-translational modification of proteins. As signalling strategy conserved in all domains of life, it modulates substrate activity, localisation, stability or interactions, thereby regulating a variety of ...
M. Schuller, I. Ahel
semanticscholar +3 more sources
TARG1 protects against toxic DNA ADP-ribosylation [PDF]
Nucleic Acids Research, 2021 ADP-ribosylation is a modification that targets a variety of macromolecules and regulates a diverse array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases and reversed by ADP-ribosylhydrolases.
Callum Tromans-Coia +5 more
semanticscholar +2 more sources