Results 11 to 20 of about 105,381 (168)
Serine ADP-ribosylation in Drosophila provides insights into the evolution of reversible ADP-ribosylation signalling [PDF]
Nature Communications, 2023 In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial importance to mark sites of DNA damage as well as recruit and regulate repairs factors.
Pietro Fontana +9 more
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ADP-Ribosylation in Antiviral Innate Immune Response
Pathogens, 2023 Adenosine diphosphate (ADP)-ribosylation is a reversible post-translational modification catalyzed by ADP-ribosyltransferases (ARTs). ARTs transfer one or more ADP-ribose from nicotinamide adenine dinucleotide (NAD+) to the target substrate and release ...
Qian Du, Ying Miao, Wei He, Hui Zheng
doaj +2 more sources
ADP-ribosylation from molecular mechanisms to therapeutic implications. [PDF]
, 2023 ADP-ribosylation is a ubiquitous modification of biomolecules, including proteins and nucleic acids, that regulates various cellular functions in all kingdoms of life.
I Ahel (7716542) +3 more
core +6 more sources
Functional roles of ADP-ribosylation writers, readers and erasers
Frontiers in Cell and Developmental Biology, 2022 ADP-ribosylation is a reversible post-translational modification (PTM) tightly regulated by the dynamic interplay between its writers, readers and erasers.
Ping Li +4 more
doaj +1 more source
Pathogens, 2023 Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar +3 more
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Temporal and Site-Specific ADP-Ribosylation Dynamics upon Different Genotoxic Stresses
Cells, 2021 The DNA damage response revolves around transmission of information via post-translational modifications, including reversible protein ADP-ribosylation.
Sara C. Buch-Larsen +3 more
doaj +1 more source
Uncovering the Invisible: Mono-ADP-ribosylation Moved into the Spotlight
Cells, 2021 Adenosine diphosphate (ADP)-ribosylation is a nicotinamide adenine dinucleotide (NAD+)-dependent post-translational modification that is found on proteins as well as on nucleic acids.
Ann-Katrin Hopp, Michael O. Hottiger
doaj +1 more source
iScience, 2021 Summary: While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts promotes
Lavinia Bisceglie +11 more
doaj +1 more source
Cell Reports, 2020 Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée +5 more
doaj +1 more source
Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
Life Science Alliance, 2021 This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
Danique Beijer +10 more
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