Results 21 to 30 of about 105,381 (168)
Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.
PLoS ONE, 2021 ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson +2 more
doaj +1 more source
The interplay of TARG1 and PARG protects against genomic instability
Cell Reports, 2023 Summary: The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that removes aspartate/
Joséphine Groslambert +10 more
doaj +1 more source
Pathogens, 2023 The chemical modification of cellular macromolecules by the transfer of ADP-ribose unit(s), known as ADP-ribosylation, is an ancient homeostatic and stress response control system.
Giuliana Catara +2 more
doaj +1 more source
The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 ADP-ribosylation is a widespread posttranslational modification that is of particular therapeutic relevance due to its involvement in DNA repair. In response to DNA damage, PARP1 and 2 are the main enzymes that catalyze ADP-ribosylation at damage sites ...
Kira Schützenhofer +2 more
doaj +1 more source
TARG1 protects against toxic DNA ADP-ribosylation [PDF]
, 2021 ADP-ribosylation is a modification that targets a variety of macromolecules and regulates a diverse array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases and reversed by ADP-ribosylhydrolases.
Sanchi, Andrea +7 more
core +1 more source
Mechanistic insights into the HPF1/PARP1 complex [PDF]
, 2022 ADP-ribosylation is a vital post-translational modification associated with a large range of processes including DNA damage repair, transcription, replication, mitosis, inflammation and cell death.
Zobel, Florian Franz Henning
core +1 more source
Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin. [PDF]
PLoS ONE, 2015 Clostridium perfringens iota toxin is a binary toxin composed of the enzymatically active component Ia and receptor binding component Ib. Ia is an ADP-ribosyltransferase, which modifies Arg177 of actin.
Alexander Belyy +5 more
doaj +1 more source
TARG1 protects against DNA ADP-ribosylation stress [PDF]
, 2021 ADP-ribosylation is a modification that can target a variety of macromolecules and can regulate an array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases that use NAD+ as a cosubstrate to transfer ADP-ribose onto ...
Tromans-Coia, Callum
core +1 more source
BIOCHEMICAL AND STRUCTURAL STUDIES OF PATHOGEN EFFECTORS ASSOCIATED WITH UBIQUITIN ADP-RIBOSYLATION
, 2023 Ubiquitination and ADP-ribosylation are reversible post-translational modifications involved in various cellular activities. Pathogens like Legionella pneumophila and Chromobacterium violaceum target host ubiquitin system via modifications involving ADP ...
Zhengrui Zhang (17081689)
core +1 more source
, 2019 ADP-ribosylation is a post-translational modification that, until recently, has remained elusive to study at the cellular level. Previously dependent on radioactive tracers to identify ADP-ribosylation targets, several advances in mass spectrometric ...
Takashi Maejima (559317) +6 more
core +3 more sources