Results 21 to 30 of about 61,359 (235)
Cell Reports, 2020 Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée +5 more
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Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
Life Science Alliance, 2021 This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
Danique Beijer +10 more
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The interplay of TARG1 and PARG protects against genomic instability
Cell Reports, 2023 Summary: The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that removes aspartate/
Joséphine Groslambert +10 more
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Reversible ADP-ribosylation of RNA [PDF]
Nucleic Acids Research, 2019 AbstractADP-ribosylation is a reversible chemical modification catalysed by ADP-ribosyltransferases such as PARPs that utilize nicotinamide adenine dinucleotide (NAD+) as a cofactor to transfer monomer or polymers of ADP-ribose nucleotide onto macromolecular targets such as proteins and DNA.
Munnur, D +7 more
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Pathogens, 2023 The chemical modification of cellular macromolecules by the transfer of ADP-ribose unit(s), known as ADP-ribosylation, is an ancient homeostatic and stress response control system.
Giuliana Catara +2 more
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Ubiquitination accomplished: E1 and E2 enzymes were not necessary [PDF]
, 2016 Qiu et al. (2016) show that a mono-ADP-ribosyltransferase, SdeA, from Legionella pneumophila catalyzes ADP-ribosylation of ubiquitin, allowing SdeA to modify substrate with ubiquitin in the absence of E1 and E2 ...
Huang, Danny T., Nakasone, Mark
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The Making and Breaking of Serine-ADP-Ribosylation in the DNA Damage Response
Frontiers in Cell and Developmental Biology, 2021 ADP-ribosylation is a widespread posttranslational modification that is of particular therapeutic relevance due to its involvement in DNA repair. In response to DNA damage, PARP1 and 2 are the main enzymes that catalyze ADP-ribosylation at damage sites ...
Kira Schützenhofer +2 more
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The role of ADP-ribosylation in regulating DNA interstrand crosslink repair [PDF]
, 2016 ADP-ribosylation by ADP-ribosyltransferases (ARTs) has a wellestablished role in DNA strand break repair by promoting enrichment of repair factors at damage sites through ADP-ribose interaction domains. Here, we exploit the simple eukaryote Dictyostelium
Ahel, Ivan +10 more
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Roles of Asp179 and Glu270 in ADP-Ribosylation of Actin by Clostridium perfringens Iota Toxin. [PDF]
PLoS ONE, 2015 Clostridium perfringens iota toxin is a binary toxin composed of the enzymatically active component Ia and receptor binding component Ib. Ia is an ADP-ribosyltransferase, which modifies Arg177 of actin.
Alexander Belyy +5 more
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Molecular Control of the Amount, Subcellular Location and Activity State of Translation Elongation Factor 2 (eEF-2) in Neurons Experiencing Stress [PDF]
, 2013 Eukaryotic elongation factor 2 (eEF-2) is an important regulator of the protein translation machinery wherein it controls the movement of the ribosome along the mRNA.
Argüelles-Castilla, Sandro +5 more
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