Results 31 to 40 of about 39,153 (185)
Role of APD-Ribosylation in Bone Health and Disease
Cells, 2019 The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD+) to acceptor proteins is known as ADP-ribosylation.
Chun Wang, Gabriel Mbalaviele
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Computational and Structural Biotechnology Journal, 2022 ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes.
Andrea Hloušek-Kasun +9 more
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The regulatory landscape of the human HPF1- and ARH3-dependent ADP-ribosylome
Nature Communications, 2021 ADP-ribosylation is regulated by HPF1 and ARH3, but the cellular target spectrum of these enzymes is not fully understood. Here, the authors use quantitative proteomics to define the HPF1- and ARH3-dependent ADP-ribosylome, providing evidence that mono ...
Ivo A. Hendriks +9 more
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The ADP-Ribosylating Toxins of Salmonella [PDF]
Toxins, 2019 A number of pathogenic bacteria utilize toxins to mediate disease in a susceptible host. The foodborne pathogen Salmonella is one of the most important and well-studied bacterial pathogens. Recently, whole genome sequence characterizations revealed the presence of multiple novel ADP-ribosylating toxins encoded by a variety of Salmonella serovars.
Rachel A. Cheng, Martin Wiedmann
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Proteome-wide identification of the endogenous ADP-ribosylome of mammalian cells and tissue
Nature Communications, 2016 ADP-ribosylation is a reversible post-translational protein modification involved in many cellular processes. Here the authors describe a sensitive approach for the analysis of ADP-ribosylation sites under physiologic conditions and identify lysine ...
Rita Martello +7 more
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Regulation of Rad52-dependent replication fork recovery through serine ADP-ribosylation of PolD3
Nature Communications, 2023 Although Poly(ADP-ribose)-polymerases (PARPs) are key regulators of genome stability, how site-specific ADP-ribosylation regulates DNA repair is unclear.
Frederick Richards +7 more
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Nature Communications, 2023 In the mammalian DNA damage response, ADP-ribosylation signalling is of crucial importance to mark sites of DNA damage as well as recruit and regulate repairs factors.
Pietro Fontana +9 more
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eLife, 2021 Poly(ADP-ribose) polymerase 7 (PARP-7) has emerged as a critically important member of a large enzyme family that catalyzes ADP-ribosylation in mammalian cells. PARP-7 is a critical regulator of the innate immune response.
Kelsie M Rodriguez +10 more
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ADP-Ribosylation Regulates the Signaling Function of IFN-γ
Frontiers in Immunology, 2021 Murine T cells express the GPI-anchored ADP-ribosyltransferase 2.2 (ARTC2.2) on the cell surface. In response to T cell activation or extracellular NAD+ or ATP-mediated gating of the P2X7 ion channel ARTC2.2 is shed from the cell surface as a soluble ...
Stephan Menzel +6 more
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ADP-ribosyl-N3: A Versatile Precursor for Divergent Syntheses of ADP-ribosylated Compounds [PDF]
Molecules, 2017 Adenosine diphosphate-ribose (ADP-ribose) and its derivatives play important roles in a series of complex physiological procedures. The design and synthesis of artificial ADP-ribosylated compounds is an efficient way to develop valuable chemical biology tools and discover new drug candidates.
Lingjun Li +6 more
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