Results 31 to 40 of about 214,575 (242)

TIR-catalyzed ADP-ribosylation reactions produce signaling molecules for plant immunity

bioRxiv, 2022
Plant pathogen-activated immune signaling by nucleotide-binding leucine-rich repeat (NLR) receptors with an N-terminal Toll/Interleukin-1 receptor (TIR) domain converges on Enhanced Disease Susceptibility 1 (EDS1) and its direct partners Phytoalexin ...
Ao Jia, Shijia Huang, Wen Song, Junli Wang, Yonggang Meng, Yue Sun, Lina Xu, Henriette Laessle, J. Jirschitzka, Jiao Hou, Tiantian Zhang, Wenquan Yu, Giuliana Hessler, Ertong Li, Shoucai Ma, Dongli Yu, J. Gebauer, U. Baumann, Xiaohui Liu, Zhifu Han, Junbiao Chang, J. Parker, J. Chai   +22 more
semanticscholar   +1 more source

Characterization of an Aedes ADP-Ribosylation Protein Domain and Role of Post-Translational Modification during Chikungunya Virus Infection

Pathogens, 2023
Poly ADP-ribose polymerases (PARPs) catalyze ADP-ribosylation, a subclass of post-translational modification (PTM). Mono-ADP-ribose (MAR) moieties bind to target molecules such as proteins and nucleic acids, and are added as part of the process which ...
Ramesh Kumar, Divya Mehta, Debasis Nayak, Sujatha Sunil   +3 more
doaj   +1 more source

HPF1-dependent histone ADP-ribosylation triggers chromatin relaxation to promote the recruitment of repair factors at sites of DNA damage

Nature Structural & Molecular Biology, 2023
Poly(ADP-ribose) polymerase 1 (PARP1) activity is regulated by its co-factor histone poly(ADP-ribosylation) factor 1 (HPF1). The complex formed by HPF1 and PARP1 catalyzes ADP-ribosylation of serine residues of proteins near DNA breaks, mainly PARP1 and ...
Rebecca Smith, Siham Zentout, Magdalena B. Rother, Nicolas Bigot, Catherine Chapuis, Alexandra Mihuț, Florian Zobel, I. Ahel, Haico van Attikum, Gyula Timinszky, S. Huet   +10 more
semanticscholar   +1 more source

Temporal and Site-Specific ADP-Ribosylation Dynamics upon Different Genotoxic Stresses

Cells, 2021
The DNA damage response revolves around transmission of information via post-translational modifications, including reversible protein ADP-ribosylation.
Sara C. Buch-Larsen, Alexandra K. L. F. S. Rebak, Ivo A. Hendriks, Michael L. Nielsen   +3 more
doaj   +1 more source

Chemoenzymatic and Synthetic Approaches To Investigate Aspartate- and Glutamate-ADP-Ribosylation

Journal of the American Chemical Society, 2023
We report here chemoenzymatic and fully synthetic methodologies to modify aspartate and glutamate side chains with ADP-ribose at specific sites on peptides. Structural analysis of aspartate and glutamate ADP-ribosylated peptides reveals near-quantitative
Kyuto Tashiro, Sven Wijngaarden, J. Mohapatra, J. Rack, I. Ahel, D. Filippov, G. Liszczak   +6 more
semanticscholar   +1 more source

Molecular basis for the reversible ADP-ribosylation of guanosine bases

Molecules and Cells, 2023
Summary Modification of nucleic acids by ADP-ribosylation is catalyzed by various ADP-ribosyltransferases, including the DarT enzyme. The latter is part of the bacterial toxin-antitoxin (TA) system DarTG, which was shown to provide control of DNA ...
M. Schuller, R. Raggiaschi, Petra Mikolčević, J. Rack, Antonio Ayala Ariza, YuGeng Zhang, R. Ledermann, Christoph C Tang, A. Mikoč, I. Ahel   +9 more
semanticscholar   +1 more source

ADP-ribosylation of arginine [PDF]

Amino Acids, 2010
Arginine adenosine-5'-diphosphoribosylation (ADP-ribosylation) is an enzyme-catalyzed, potentially reversible posttranslational modification, in which the ADP-ribose moiety is transferred from NAD(+) to the guanidino moiety of arginine. At 540 Da, ADP-ribose has the size of approximately five amino acid residues.
Laing, Sabrina, Unger, Mandy, Koch-Nolte, Friedrich, Haag, Friedrich   +3 more
openaire   +2 more sources

PARP14 is a writer, reader, and eraser of mono-ADP-ribosylation

bioRxiv, 2023
PARP14/BAL2 is a large multidomain enzyme involved in signaling pathways with relevance to cancer, inflammation, and infection. Inhibition of its mono-ADP-ribosylating PARP homology domain and its three ADP-ribosyl binding macro domains has been regarded
A. Torretta, Constantinos Chatzicharalampous, Carmen Ebenwaldner, H. Schüler   +3 more
semanticscholar   +1 more source

Mono-ADP-ribosylation by PARP10 and PARP14 in genome stability

NAR Cancer, 2023
ADP-ribosylation is a post-translational modification involved in a variety of processes including DNA damage repair, transcriptional regulation, and cellular proliferation.
Ashna Dhoonmoon, Claudia M. Nicolae
semanticscholar   +1 more source

MyoD induces ARTD1 and nucleoplasmic poly-ADP-ribosylation during fibroblast to myoblast transdifferentiation

iScience, 2021
Summary: While protein ADP-ribosylation was reported to regulate differentiation and dedifferentiation, it has so far not been studied during transdifferentiation. Here, we found that MyoD-induced transdifferentiation of fibroblasts to myoblasts promotes
Lavinia Bisceglie, Ann-Katrin Hopp, Kapila Gunasekera, Roni H. Wright, François Le Dily, Enrique Vidal, Alessandra Dall’Agnese, Luca Caputo, Chiara Nicoletti, Pier Lorenzo Puri, Miguel Beato, Michael O. Hottiger   +11 more
doaj   +1 more source