Results 41 to 50 of about 214,575 (242)
Nature Cell Biology, 2022 DNA damage shuts down genome-wide transcription to prevent transcriptional mutagenesis and to initiate repair signalling, but the mechanism to stall elongating RNA polymerase II (Pol II) is not fully understood.
Huanyi Fu +13 more
semanticscholar +1 more source
Cell Reports, 2020 Summary: ADP-ribosylation of proteins is crucial for fundamental cellular processes. Despite increasing examples of DNA ADP-ribosylation, the impact of this modification on DNA metabolism and cell physiology is unknown. Here, we show that the DarTG toxin-
Emeline Lawarée +5 more
doaj +1 more source
Biallelic ADPRHL2 mutations in complex neuropathy affect ADP ribosylation and DNA damage response
Life Science Alliance, 2021 This work studies known and new ADPRHL2 mutations with different disease mechanisms overall indicating that loss of nuclear ARH3 alone is pathogenic via dysregulated nuclear ADP ribosylation.
Danique Beijer +10 more
doaj +1 more source
ADP-ribosylation of RNA in mammalian cells is mediated by TRPT1 and multiple PARPs
Nucleic Acids Research, 2022 RNA function relies heavily on posttranscriptional modifications. Recently, it was shown that certain PARPs and TRPT1 can ADP-ribosylate RNA in vitro. Traditionally, intracellular ADP-ribosylation has been considered mainly as a protein posttranslational
L. Weixler, Karla L. H. Feijs, R. Žaja
semanticscholar +1 more source
Selective monitoring of the protein-free ADP-ribose released by ADP-ribosylation reversal enzymes.
PLoS ONE, 2021 ADP-ribosylation is a key post-translational modification that regulates a wide variety of cellular stress responses. The ADP-ribosylation cycle is maintained by writers and erasers.
Samuel Kasson +2 more
doaj +1 more source
bioRxiv, 2021 SARS-CoV-2 non-structural protein 3 (Nsp3) contains a macrodomain that is essential for virus replication and is thus an attractive target for drug development.
L. Russo +11 more
semanticscholar +1 more source
The interplay of TARG1 and PARG protects against genomic instability
Cell Reports, 2023 Summary: The timely removal of ADP-ribosylation is crucial for efficient DNA repair. However, much remains to be discovered about ADP-ribosylhydrolases. Here, we characterize the physiological role of TARG1, an ADP-ribosylhydrolase that removes aspartate/
Joséphine Groslambert +10 more
doaj +1 more source
Nature Communications, 2022 Serum tyrosine levels increase during aging, neurocognitive, metabolic, and cardiovascular disorders. However, calorie restriction (CR) and sleep lower serum tyrosine levels.
Megha Jhanji +10 more
semanticscholar +1 more source
BIOCHEMICAL AND STRUCTURAL STUDIES OF PATHOGEN EFFECTORS ASSOCIATED WITH UBIQUITIN ADP-RIBOSYLATION
, 2023 Ubiquitination and ADP-ribosylation are reversible post-translational modifications involved in various cellular activities. Pathogens like Legionella pneumophila and Chromobacterium violaceum target host ubiquitin system via modifications involving ADP ...
Zhengrui Zhang (17081689)
core +1 more source
, 2019 ADP-ribosylation is a post-translational modification that, until recently, has remained elusive to study at the cellular level. Previously dependent on radioactive tracers to identify ADP-ribosylation targets, several advances in mass spectrometric ...
Takashi Maejima (559317) +6 more
core +3 more sources