Results 61 to 70 of about 214,575 (242)
Roles of ADP-Ribosylation during Infection Establishment by Trypanosomatidae Parasites
Pathogens, 2023 ADP-ribosylation is a reversible post-translational protein modification, which is evolutionarily conserved in prokaryotic and eukaryotic organisms.
Joshua Dowling, Craig L. Doig
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HPF1 completes the PARP active site for DNA damage-induced ADP-ribosylation
Nature, 2020 The anti-cancer drug target poly(ADP-ribose) polymerase 1 (PARP1) and its close homologue, PARP2, are early responders to DNA damage in human cells1,2.
M. Suskiewicz +11 more
semanticscholar +1 more source
Mono ADP-ribosylation and Poly ADP-ribosylation of Proteins [PDF]
, 1981 Postsynthetic modification of proteins by transfer of ADP-ribosyl groups from NAD has been shown to occur in numerous systems. Besides ADPR transferase reactions associated with the action of bacterial toxins and viruses, ADP ribosylation reactions were also observed in eukaryotic cells (cf.
H. Hilz +3 more
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Mechanistic insights into the HPF1/PARP1 complex
, 2022 ADP-ribosylation is a vital post-translational modification associated with a large range of processes including DNA damage repair, transcription, replication, mitosis, inflammation and cell death.
Zobel, Florian Franz Henning
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Role of APD-Ribosylation in Bone Health and Disease
Cells, 2019 The transfer of adenosine diphosphate (ADP)-ribose unit(s) from nicotinamide adenine dinucleotide (NAD+) to acceptor proteins is known as ADP-ribosylation.
Chun Wang, Gabriel Mbalaviele
doaj +1 more source
Recruitment of AP-1 clathrin adaptors to liposomal membranes [PDF]
, 2004 Protein and membrane traffic between organelles within the endocytic and exocytic pathway is mediated most prominently by coated vesicles. These vesicles are formed by the assembly of cytosolic coat proteins onto the donor membrane, which deform it into ...
Meyer, Daniel Markus
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TARG1 protects against DNA ADP-ribosylation stress
, 2021 ADP-ribosylation is a modification that can target a variety of macromolecules and can regulate an array of important cellular processes. ADP-ribosylation is catalysed by ADP-ribosyltransferases that use NAD+ as a cosubstrate to transfer ADP-ribose onto ...
Tromans-Coia, Callum
core +1 more source
Computational and Structural Biotechnology Journal, 2022 ADP-ribosylation is an ancient, highly conserved, and reversible covalent modification critical for a variety of endogenous processes in both prokaryotes and eukaryotes.
Andrea Hloušek-Kasun +9 more
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Cells, 2021 ADP-ribosylation is a post-translational protein modification catalyzed by a family of proteins known as poly-ADP-ribose polymerases. PARP7 (TIPARP; ARTD14) is a mono-ADP-ribosyltransferase involved in several cellular processes, including responses to ...
Marit Rasmussen +8 more
semanticscholar +1 more source
Legionella pneumophila modulates host energy metabolism by ADP-ribosylation of ADP/ATP translocases
bioRxiv, 2021 The intracellular pathogen Legionella pneumophila delivers more than 330 effectors into host cells by its Dot/Icm secretion system. Those effectors direct the biogenesis of the Legionella-containing vacuole (LCV) that permits its intracellular survival ...
Jiaqi Fu +5 more
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