Results 81 to 90 of about 39,153 (185)

Proteome Analysis of Corynebacterium diphtheriae–Macrophage Interaction

PROTEOMICS, Volume 26, Issue 8, Page 9-28, August 2026.
ABSTRACT Contact of Corynebacterium diphtheriae with macrophages induces adaptations on both bacterial and cellular sides. The study presented here was aiming to shed light on the simultaneous intracellular adaptation of the bacteria and changes in the proteome of the phagocytes in response to the internalization of C. diphtheriae.
Luca Musella, Jens Möller, Christopher Lischer, Julio Vera‐Gonzalez, Jörg Hofmann, Lisa Ott, Andreas Burkovski   +6 more
wiley   +1 more source

Replacement soaking for human tankyrase 2 enables studies on substrate analogues and inhibitors

Acta Crystallographica Section D, Volume 82, Issue 8, Page 998-1008, August 2026.
Replacement soaking, also known as cross‐soaking, is a compelling method for solving complex structures in cases where traditional soaking and co‐crystallization approaches fail. This method is demonstrated with human tankyrase 2, and new crystal structures of complexes with nanomolar inhibitors and an analogue of the substrate NAD+ are reported ...
Johan Pääkkönen, Sven T. Sowa, Chiara Bosetti, Lari Lehtiö   +3 more
wiley   +1 more source

Legionella metaeffector MavL reverses ubiquitin ADP-ribosylation via a conserved arginine-specific macrodomain

Nature Communications
ADP-ribosylation is a reversible post-translational modification involved in various cellular activities. Removal of ADP-ribosylation requires (ADP-ribosyl)hydrolases, with macrodomain enzymes being a major family in this category.
Zhengrui Zhang, Jiaqi Fu, Johannes Gregor Matthias Rack, Chuang Li, Jim Voorneveld, Dmitri V. Filippov, Ivan Ahel, Zhao-Qing Luo, Chittaranjan Das   +8 more
doaj   +1 more source

RBOHC‐Generated ROS Tune MIZ2/GNOM‐Dependent Root Halotropism in Arabidopsis

Plant, Cell &Environment, Volume 49, Issue 9, Page 7151-7154, September 2026.
Amir Cohen, Matan Franko, Yvonne Kiere, Yonatan Wexler, Doron Shkolnik   +4 more
wiley   +1 more source

Protein stereo‐folding and proteostasis: A new path for clinical and translational medicine

Clinical and Translational Discovery, Volume 6, Issue 4, August 2026.
Yuhan Wang, Yuyang Qiu, Xiangdong Wang
wiley   +1 more source

Nucleolar-nucleoplasmic shuttling of TARG1 and its control by DNA damage-induced poly-ADP-ribosylation and by nucleolar transcription

Scientific Reports, 2018
Macrodomains are conserved protein folds associated with ADP-ribose binding and turnover. ADP-ribosylation is a posttranslational modification catalyzed primarily by ARTD (aka PARP) enzymes in cells.
Mareike Bütepage, Christian Preisinger, Alexander von Kriegsheim, Anja Scheufen, Eva Lausberg, Jinyu Li, Ferdinand Kappes, Regina Feederle, Sabrina Ernst, Laura Eckei, Sarah Krieg, Gerhard Müller-Newen, Giulia Rossetti, Karla L. H. Feijs, Patricia Verheugd, Bernhard Lüscher   +15 more
doaj   +1 more source

PARP7 is a proteotoxic stress sensor that labels proteins for degradation

The EMBO Journal
ADP-ribosylation is a post-translational modification that plays a critical role in cellular stress responses. We have observed that during proteotoxic stress, cellular ADP-ribosylation increases, with ADP-ribosylated proteins accumulating in cytoplasmic
Nonso J Ikenga, Jörg Vervoorts, Bernhard Lüscher, Roko Žaja, Karla L H Feijs-Žaja   +4 more
doaj   +1 more source

Cell type-dependent induction of type I interferon and PARP1 activation in astrocytes and neurons during chikungunya virus infection

Microbiology Spectrum
Chikungunya virus, a mosquito-borne alphavirus, causes fever, rash, arthritis, and neurological disorders. Its non-structural protein 3 harbors a macrodomain, a key neurovirulence factor that removes adenosine diphosphate ribose from ADP-ribosylated ...
Lisa Pieterse, Taewoo Kim, Che-Yuan Chang, Ilsa T. Kirby, Benjamin H. Nguyen, Larissa Cortes Morales, Rodney Eric Williams, Easwaran Sreekumar, Michael S. Cohen, Anthony K. L. Leung, Diane E. Griffin, Rachy Abraham   +11 more
doaj   +1 more source

Untargeted Proteomics Identifies Plant Substrates of the Bacterial‐Derived ADP‐Ribosyltransferase AvrRpm1

Plant Direct
One class of enzymes that plant pathogens employ to manipulate innate immunity and physiology of the infected cells is host‐targeted ADP‐ribosyltransferases. The bacterial pathogen Pseudomonas syringae uses its Type III secretion system to inject several
Simranjit Kaur, Thomas Colby, Domenika Thieme, Carsten Proksch, Susanne Matschi, Ivan Matić, Lennart Wirthmueller   +6 more
doaj   +1 more source

ADP Ribosylation [PDF]

, 2020
openaire   +1 more source