Results 81 to 90 of about 214,575 (242)

Versatile and sensitive detection of mono- and poly(ADP-ribosyl)ation reveals XRCC1-dependent remodelling of PARP1 signalling

Nature Communications
ADP-ribosylation has long been recognised as a key regulator of essential signalling pathways, including the DNA damage response. However, only recent and ongoing technological advances are beginning to make it possible to investigate its distinct forms ...
Helen Dauben, Mihaela Mihaljević, Andreas Kolvenbach, Maria Dilia Palumbieri, Chrysi Kapsali, Ina Huppertz, Ivan Matić   +6 more
doaj   +1 more source

Analysis of Mono-ADP-Ribosylation Levels in Human Colorectal Cancer

Cancer Management and Research, 2021
Chuan-Ling Wang, Yi Tang, Ming Li, Ming Xiao, Qing-Shu Li, Lian Yang, Xian Li, Ling Yin, Ya-Lan Wang Department of Pathology, Molecular Medicine and Cancer Research Center, Chongqing Medical University, Chongqing, 400016, People’s Republic of ...
Wang CL, Tang Y, Li M, Xiao M, Li QS, Yang L, Li X, Yin L, Wang YL   +8 more
doaj  

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Androgen signaling uses a writer and a reader of ADP-ribosylation to regulate protein complex assembly

Nature Communications, 2021
Androgen signaling through the androgen receptor (AR) directs gene expression in both normal and prostate cancer cells. Androgen regulates multiple aspects of the AR life cycle, including its localization and post-translational modification, but ...
Chun-Song Yang, Kasey Jividen, Teddy Kamata, Natalia M. Dworak, Luke T. Oostdyk, Bartlomiej Remlein, Y. Pourfarjam, In-Kwon Kim, Kangping Du, T. Abbas, N. Sherman, D. Wotton, B. Paschal   +12 more
semanticscholar   +1 more source

Phosphatidylinositol 4‐kinase as a target of pathogens—friend or foe?

FEBS Letters, EarlyView.
This graphical summary illustrates the roles of phosphatidylinositol 4‐kinases (PI4Ks). PI4Ks regulate key cellular processes and can be hijacked by pathogens, such as viruses, bacteria and parasites, to support their intracellular replication. Their dual role as essential host enzymes and pathogen cofactors makes them promising drug targets.
Ana C. Mendes, Guilherme M. Azevedo, Amanda P. Barcellos, Diana Bahia   +3 more
wiley   +1 more source

In vivo vizualisation of mono-ADP-ribosylation by dPARP16 upon amino-acid starvation

eLife, 2016
PARP catalysed ADP-ribosylation is a post-translational modification involved in several physiological and pathological processes, including cellular stress.
Angelica Aguilera-Gomez, Marinke M van Oorschot, Tineke Veenendaal, Catherine Rabouille   +3 more
doaj   +1 more source

The Critical Role of PARPs in Regulating Innate Immune Responses

Frontiers in Immunology, 2021
Poly (adenosine diphosphate-ribose) polymerases (PARPs) are a family of proteins responsible for transferring ADP-ribose groups to target proteins to initiate the ADP-ribosylation, a highly conserved and fundamental post-translational modification in all
Huifang Zhu, Yan-Dong Tang, Guoqing Zhan, Chenhe Su, Chunfu Zheng   +4 more
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Biochemical and Developmental Characterization of ADP-ribosylation Factors, A Family of 20 kDa Guanine Nucleotide-binding Proteins

The cholera toxin A subunit (CT-A) is an ADP-ribosyltransferase; its principal cellular substrates are the α subunits of Gs, the stimulatory G protein of adenylyl cyclase.
Tsai, S.-C., Adamik, R., Tsuchiya, M., Vaughan, M., Welsh, C. F., Price, S. R., Moss, J.   +6 more
core   +2 more sources

Mechanistic insights into the three steps of poly(ADP-ribosylation) reversal

Nature Communications, 2021
Poly(ADP-ribosyl)ation (PAR) is a versatile and complex posttranslational modification composed of repeating units of ADP-ribose arranged into linear or branched polymers.
J. Rack, Qiang Liu, V. Zorzini, Jim Voorneveld, A. Ariza, Kourosh Honarmand Ebrahimi, Julia M Reber, Sarah C Krassnig, D. Ahel, G. A. van der Marel, A. Mangerich, J. Mccullagh, D. Filippov, I. Ahel   +13 more
semanticscholar   +1 more source