Results 81 to 90 of about 7,374 (163)

ParG, a protein required for active partition of bacterial plasmids, has a dimeric ribbon-helix-helix structure

, 2003
The ParG protein (8.6 kDa) is an essential component of the DNA partition complex of multidrug resistance plasmid TP228. ParG is a dimer in solution, interacts with DNA sequences upstream of the parFG genes and also with the ParF partition protein both ...
Barillà, Daniela, Hayes, Finbarr, Golovanova, Marina, Golovanov, Alexander P.; id_orcid, Lian, Lu Yun   +4 more
core   +1 more source

Étude fonctionnelle de la poly(ADP-ribose) glycohydrolase (PARG)

, 2004
La poly(ADP-ribosylation) est une modification post-traductionnelle des protéines régulée essentiellement par la poly(ADP-ribose) polymérase I (PARP-1), synthétisant le poly(ADP-ribose), et la poly(ADP-ribose) glycohydrolase (PARG), responsable du ...
WANG, Zhao Qiu, CORTES, Ulrich
core  

Ectopic over-expression of PARG influences histone acetylation levels.

, 2015
(A) Representative Western blot of total proteins from cells transfected with empty vector (pCS2) or Myc–catalytically mutated PARG construct (pCS2-Myc-PARG_E757N) or Myc–PARG construct (pCS2-Myc-PARG) run on an 8% SDS-PAGE, and probed with anti-Myc ...
Fabio Ciccarone (132376), Michele Zampieri (132387), Micaela Caserta (833836), Marco La Fortezza (833835), Paola Caiafa (132394), Loredana Verdone (833834)   +5 more
core   +1 more source

Poly(ADP-ribosyl)gycohydrolase (PARG) prevents the accumulation of unusual replication structures during unperturbed S phase

, 2014
Poly(ADP-ribosyl)ation (PAR) has been implicated in various aspects of the cellular response to DNA damage and genome stability. Although 17 human poly(ADP-ribose) polymerase (PARP) genes have been identified, a single poly(ADP-ribose) glycohydrolase ...
Ahuja, Akshay Kumar, Lopes, Massimo; https://orcid.org/, Ray Chaudhuri, Arnab, Herrador, Raquel   +3 more
core   +1 more source

Efficacy and safety of pegzilarginase in arginase 1 deficiency (PEACE): a phase 3, randomized, double-blind, placebo-controlled, multi-centre trialResearch in context

EClinicalMedicine
Summary: Background: Arginase 1 Deficiency (ARG1-D) is a rare debilitating, progressive, inherited, metabolic disease characterized by marked increases in plasma arginine (pArg) and its metabolites, with increased morbidity, substantial reductions in ...
Rossana Sanchez Russo, Serena Gasperini, Gillian Bubb, Linda Neuman, Leslie S. Sloan, George A. Diaz, Gregory M. Enns   +6 more
doaj   +1 more source

Targeting OGG1 and PARG radiosensitises head and neck cancer cells to high-LET protons through complex DNA damage persistence

Cell Death and Disease
Complex DNA damage (CDD), containing two or more DNA lesions within one or two DNA helical turns, is a signature of ionising radiation (IR) and contributes significantly to the therapeutic effect through cell killing.
Maria Rita Fabbrizi, Catherine M. Nickson, Jonathan R. Hughes, Emily A. Robinson, Karthik Vaidya, Carlos P. Rubbi, Andrzej Kacperek, Helen E. Bryant, Thomas Helleday, Jason L. Parsons   +9 more
doaj   +1 more source

Kinetics of Human Serum Albumin Adsorption on Polycation Functionalized Silica

Biomolecules
The adsorption kinetics of human serum albumin (HSA) on bare and poly-L-arginine (PARG)-modified silica substrates were investigated using reflectometry and atomic force microscopy (AFM).
Małgorzata Nattich-Rak, Dominik Kosior, Maria Morga, Zbigniew Adamczyk   +3 more
doaj   +1 more source

The signature motif and residue G450 are essential for PARG enzymatic activity.

, 2015
(A) The conserved residues G264 and E273 in the PARG signature motif of AtPARG1 are required for its enzymatic activity (left part of top panel) and creating a conserved PARG signature motif in AtPARG2 did not make it enzymatically active (right part of ...
Libo Shan (278792), Kevin Babilonia (682323), Baomin Feng (682320), Ping He (33281), Marcos V. V. de Oliveira (682321), Gonçalo A. de Souza Filho (682324), Aline C. Intorne (682322), Bo Li (112195), Chenglong Liu (317596)   +8 more
core   +1 more source

Supplementary Figure S6. PARG overexpression rescues HuR's regulation of PARPi response from Posttranscriptional Regulation of PARG mRNA by HuR Facilitates DNA Repair and Resistance to PARP Inhibitors

, 2017
PARG rescue in HuR silenced cells restores PARPi resistance. Small-molecule inhibition of HuR prevents its cytoplasmic accumulation, abrogates PARG mRNA regulation and increases PARPi sensitivity, independent of DDR status.
Charles J. Yeo (14892446), Jordan M. Winter (9582380), Matthew J. Schiewer (14898353), Michael J. Pishvaian (14928774), Akshay R. Kamath (14928768), Mahsa Zarei (14927078), Carmella Romeo (14915013), Laura Scolaro (466297), Eric Londin (14928771), Shruti Lal (14915004), Joseph A. Cozzitorto (14892437), Saswati N. Chand (14927087), Avinoam Nevler (11908675), Nicole Meisner-Kober (14923296), John M. Pascal (1326180), Jonathan R. Brody (14892449), Wei Jiang (14986), Karen E. Knudsen (10024169)   +17 more
core   +1 more source

Recruitment of the ParG segregation protein to different affinity DNA sites

, 2009
The segrosome is the nucleoprotein complex that mediates accurate plasmid segregation. In addition to its multifunctional role in segrosome assembly, the ParG protein of multiresistance plasmid TP228 is a transcriptional repressor of the parFG partition ...
Zampini, Massimiliano, Barillà, Daniela, Hayes, Finbarr, Bailey, Simon E S, Derome, Andrew   +4 more
core   +1 more source