Results 81 to 90 of about 12,704 (204)

Sabotaged Integral HSC Heterogeneity Underlies Essential Thrombocythemia Development

Advanced Science, Volume 13, Issue 7, 3 February 2026.
Single‐cell RNA sequencing (scRNA‐seq) maps how distinct driver mutations remodel hematopoietic stem cell (HSC) programs across essential thrombocythemia (ET). Comparative analysis uncovers both shared and subtype‐specific molecular signatures, identifies a triple‐negative (TN)‐associated HSC population enriched with malignant traits, and reveals the ...
Jingyuan Tong, Di Wang, Haoze Song, Ting Sun, Yanhong Zhao, Wenjing Gu, Lexuan Lin, Yitong Zhao, Yipeng Liang, Xu Jin, Rongfeng Fu, Mankai Ju, Jie Gao, Jinfa Ma, Chengjie Gao, Anqi Zhang, Zhijian Xiao, Erlie Jiang, Renchi Yang, Shihui Ma, Lei Zhang, Lihong Shi   +21 more
wiley   +1 more source

The Ups and Downs of Tannins as Inhibitors of Poly(ADP-Ribose)glycohydrolase

Molecules, 2011
DNA damage to cells activates nuclear poly(ADP-ribose)polymerases (PARPs) and the poly(ADP-ribose) (PAR) synthesized is rapidly cleaved into ADP-ribose (ADPR) by PAR glycohydrolase (PARG) action.
Felix R. Althaus, Philippe Wyrsch, Christian Blenn   +2 more
doaj   +1 more source

PARG Protein Regulation Roles in Drosophila Longevity Control

International Journal of Molecular Sciences
Aging, marked by a gradual decline in physiological function and heightened vulnerability to age-related diseases, remains a complex biological process with multifaceted regulatory mechanisms. Our study elucidates the critical role of poly(ADP–ribose) glycohydrolase (PARG), responsible for catabolizing poly(ADP–ribose) (pADPr) in the aging process by ...
Guillaume Bordet, Alexei V. Tulin
openaire   +2 more sources

PARG deficiency is neither synthetic lethal with BRCA1 nor PTEN deficiency [PDF]

Cancer Cell International, 2016
Poly(ADP-ribose) polymerase (PARP) inhibitors have entered the clinics for their promising anticancer effect as adjuvant in chemo- and radiotherapy and as single agent on BRCA-mutated tumours. Poly(ADP-ribose) glycohydrolase (PARG) deficiency was also shown to potentiate the cytotoxicity of genotoxic agents and irradiation.
Noll, Aurélia, Illuzzi, Giuditta, Amé, Jean-Christophe, Dantzer, Françoise, Schreiber, Valérie   +4 more
openaire   +2 more sources

Programmable Hydrogels: Frontiers in Dynamic Closed‐Loop Systems, Biomimetic Synergy, and Clinical Translation

Advanced Science, Volume 12, Issue 47, December 18, 2025.
This review summarizes the design principles and key features of programmable hydrogels that respond to multiple stimuli. It then delves into the cutting‐edge mechanisms of self‐executing systems, highlighting their role as the cornerstone of next‐generation programmable hydrogels (NGPHs).
Guangli Xiang, Bohan Yin, Behzad Shiroud Heidari, George Youssef, Monika Gosecka, Mateusz Gosecki, Fernando G. Torres, Siu Hong Dexter Wong, Jagan Mohan Dodda   +8 more
wiley   +1 more source

Performance Guarantees for Distributed Reachability Queries [PDF]

, 2012
In the real world a graph is often fragmented and distributed across different sites. This highlights the need for evaluating queries on distributed graphs.
Fan, Wenfei, Wang, Xin, Wu, Yinghui
core   +2 more sources

Longitudinal hippocampal iron accumulation predicts episodic memory in presymptomatic Alzheimer's disease with additional influences of tau and APOE geneotype

Alzheimer's &Dementia, Volume 21, Issue S2, December 2025.
Abstract Background Elevated brain iron deposition is recognized as a characteristic of normal aging and neurodegenerative diseases, particularly Alzheimer's disease (AD), where it correlated with amyloid‐β plaques and neurofibrillary tangles. Our study aimed to investigate the relationship between longitudinal changes in hippocampal iron deposition ...
Jing Zhou, Alfie Wearn, Julia Huck, Colleen S. Hughes, Giulia Baracchini, Elisabeth Sylvain, Jennifer Tremblay‐Mercier, Judes Poirier, John C.S. C. S. Breitner, Sylvia Villeneuve, Mallar M. Chakravarty, Christine L Tardif, Claudine J Gauthier, Ana M. Daugherty, Gary R. Turner, R. Nathan Spreng, for the PREVENT‐AD Research Group   +16 more
wiley   +1 more source

Design of Polymeric Nanocapsules for Intranasal Vaccination against Mycobacterium Tuberculosis: Influence of the Polymeric Shell and Antigen Positioning

Pharmaceutics, 2020
Tuberculosis (TB) is the leading cause of death from a single infectious microorganism and Bacillus Calmette Guerin (BCG), the only authorized vaccine, does not confer protection against pulmonary TB. Based on the hypothesis that mucosal protection could
Lara Diego-González, José Crecente-Campo, Matthew John Paul, Mahavir Singh, Rajko Reljic, María José Alonso, África González-Fernández, Rosana Simón-Vázquez   +7 more
doaj   +1 more source

Effect of varying magnetic fields on targeted gene delivery of nucleic acid-based molecules [PDF]

, 2014
This paper was presented at the 4th Micro and Nano Flows Conference (MNF2014), which was held at University College, London, UK. The conference was organised by Brunel University and supported by the Italian Union of Thermofluiddynamics, IPEM, the ...
4th Micro and Nano Flows Conference (MNF2014), Gözüaçik, D, Koşar, A, Oral, Ö, Yaǧci Acar, HF, Çikim, T, Ünal, Ö   +6 more
core  

Sex‐specific effects of neuropsychiatric symptoms on amyloid and tau pathology and white matter hyperintensity volume in preclinical Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue S3, December 2025.
Abstract Background Neuropsychiatric symptoms (NPS) are highly prevalent in Alzheimer's disease (AD) and may constitute both risk factors and early signs of the disease. Cross‐sectional and longitudinal studies have shown that NPS are associated with increased Aβ and tau burden in preclinical AD populations.
Aurélie Garrone, Yara Yakoub, Alfonso Fajardo, Ting Qiu, Amelie Metz, Mahsa Dadar, Valentin Ourry, Sylvia Villeneuve, PREVENT‐AD Research Group   +8 more
wiley   +1 more source