Results 41 to 50 of about 6,727 (169)
Metabolic Regulation of Macrophages in Health and Disease
MedComm, Volume 7, Issue 8, August 2026.Extracellular metabolites drive metabolic rewiring of glucose, lipid, and amino acid pathways in macrophages, steering their polarization toward pro‐ or anti‐inflammatory phenotypes and shaping a wide range of disease processes. Macrophages from different tissues display distinct metabolic signatures, and therapeutic strategies that target these ...
Shan Huang +6 more
wiley +1 more source
The Polymers of Life: Exploring Cellular Function Through Polymer Concepts
Advanced Science, Volume 13, Issue 33, 15 June 2026.Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley +1 more source
Nature Communications, 2020 Poly(ADP-ribose) glycohydrolase (PARG) is involved in different cellular processes including DNA repair. Here the authors reveal a role for PARG in regulating meiotic DNA double strand break induction and repair in Caenorhabditis elegans.
Eva Janisiw +8 more
doaj +1 more source
Reef fish assemblages impacted by sponges overgrowing corals
Ecosphere, Volume 17, Issue 6, June 2026.Abstract Numerous stressors are driving long‐term declines in coral cover on coral reefs, significantly impacting reef fish biodiversity and community structure. The benthic space made available by declining coral cover is often occupied by increases in other organisms, including macroalgae, encrusting ascidians, and sponges.
Saúl González‐Murcia +3 more
wiley +1 more source
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
Nature Communications, 2019 PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG ...
Jerry H. Houl +20 more
doaj +1 more source
Radiation-induced mitotic catastrophe in PARG-deficient cells [PDF]
Journal of Cell Science, 2009 Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in the regulation of chromatin structure, DNA metabolism, cell division and cell death. Through the hydrolysis of poly(ADP-ribose) (PAR), Poly(ADP-ribose) glycohydrolase (PARG) has a crucial role in the control of life-and-death balance following DNA insult.
Amé, Jean-Christophe +7 more
openaire +2 more sources
Automodification of N‐terminal serine residues facilitates PARP2 release from DNA
The FEBS Journal, Volume 293, Issue 11, Page 3274-3287, June 2026.PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar +6 more
wiley +1 more source
Frontiers in Molecular Biosciences, 2020 The molecular events that underpin genome segregation during bacterial cytokinesis have not been fully described. The tripartite segrosome complex that is encoded by the multiresistance plasmid TP228 in Escherichia coli is a tractable model to decipher ...
Marisa Caccamo +5 more
doaj +1 more source
Journal of Experimental & Clinical Cancer Research, 2021 Background Patients with ovarian cancer often present at advanced stage and, following initial treatment success, develop recurrent drug-resistant disease. PARP inhibitors (PARPi) are yielding unprecedented survival benefits for women with BRCA-deficient
Camilla Coulson-Gilmer +12 more
doaj +1 more source