Results 41 to 50 of about 7,374 (163)

The Polymers of Life: Exploring Cellular Function Through Polymer Concepts

Advanced Science, Volume 13, Issue 33, 15 June 2026.
Biomolecular phase separation reveals that a hidden layer of cellular organization is governed by the principles of polymer science. This review bridges polymer physics and cell biology, offering a primer on fundamental concepts, proposing a framework for interrogating cellular function, and synthesizing biophysical methods for decoding macromolecular ...
Mark Chen, Ashutosh Chilkoti
wiley   +1 more source

Reef fish assemblages impacted by sponges overgrowing corals

Ecosphere, Volume 17, Issue 6, June 2026.
Abstract Numerous stressors are driving long‐term declines in coral cover on coral reefs, significantly impacting reef fish biodiversity and community structure. The benthic space made available by declining coral cover is often occupied by increases in other organisms, including macroalgae, encrusting ascidians, and sponges.
Saúl González‐Murcia, Merrick Ekins, Christopher N. Battershill, Geoffrey P. Jones   +3 more
wiley   +1 more source

Radiation-induced mitotic catastrophe in PARG-deficient cells

, 2009
Poly(ADP-ribosyl)ation is a post-translational modification of proteins involved in the regulation of chromatin structure, DNA metabolism, cell division and cell death.
Biard, Denis, Dantzer, F. (Françoise), de Murcia, G. (Gilbert), Boussin, François D, Schreiber, Valérie, Murcia, Gilbert,, Biard, D. (Denis), Dantzer, Françoise, Gauthier, Laurent R., Schreiber, V. (Valerie), Boussin, François D., Amé, Jean-Christophe, Fouquerel, E. (Elise), Fouquerel, Elise, Gauthier, Laurent R, Amé, J. (Jean-Christophe)   +15 more
core   +1 more source

Poly(ADP-ribose) glycohydrolase coordinates meiotic DNA double-strand break induction and repair independent of its catalytic activity

Nature Communications, 2020
Poly(ADP-ribose) glycohydrolase (PARG) is involved in different cellular processes including DNA repair. Here the authors reveal a role for PARG in regulating meiotic DNA double strand break induction and repair in Caenorhabditis elegans.
Eva Janisiw, Marilina Raices, Fabiola Balmir, Luis F. Paulin, Antoine Baudrimont, Arndt von Haeseler, Judith L. Yanowitz, Verena Jantsch, Nicola Silva   +8 more
doaj   +1 more source

Automodification of N‐terminal serine residues facilitates PARP2 release from DNA

The FEBS Journal, Volume 293, Issue 11, Page 3274-3287, June 2026.
PARP2 is involved in detecting DNA damage and its N‐terminal role is largely unknown. Based on biochemical and biophysical data, our findings suggest that in the presence of HPF1, N‐terminal serine 8 and 73 are enriched in auto‐ADP‐ribosylation. Our results provide insight into the mechanistic role of PARP2 N‐terminus in the PARylation‐dependent ...
Saurabh Singh Dhakar, Albert Galera‐Prat, Jin Cai, Julia Preisser, Tiila‐Riikka Kiema, Andreas Ladurner, Lari Lehtiö   +6 more
wiley   +1 more source

Amino acid sequence alignment of the PARG signature from different organisms.

, 2013
The multiple alignment of the PARG signature amino acid sequences corresponding to T. cruzi PARG (accession number ABG73229); T. brucei PARG (GeneDB Systematic Name: Tb09.211.3760); C. elegans_1 PARG (accession number NP_501496) and C.
Mariana Schlesinger (134331), Mirtha M. Flawiá (134341), Salomé C. Vilchez Larrea (134311), Guillermo D. Alonso (359836), María L. Kevorkian (420979), Silvia H. Fernández Villamil (134345)   +5 more
core   +1 more source

Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death

Nature Communications, 2019
PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG ...
Jerry H. Houl, Zu Ye, Chris A. Brosey, Lakshitha P. F. Balapiti-Modarage, Sarita Namjoshi, Albino Bacolla, Daniel Laverty, Brian L. Walker, Yasin Pourfarjam, Leslie S. Warden, Naga Babu Chinnam, Davide Moiani, Roderick A. Stegeman, Mei-Kuang Chen, Mien-Chie Hung, Zachary D. Nagel, Tom Ellenberger, In-Kwon Kim, Darin E. Jones, Zamal Ahmed, John A. Tainer   +20 more
doaj   +1 more source

The role of poly(ADP-ribose) glycohydrolase (PARG) in cell death [PDF]

, 2011
The post-translational modification of proteins with poly(ADP-ribose) (PAR) occurs as an early response to genotoxic insults. The nuclear poly(ADP-ribose) polymerase 1 (PARP-1) reacts to DNA nicks, activating its catalytical function and thereby ...
Blenn, C
core   +1 more source

Genome Segregation by the Venus Flytrap Mechanism: Probing the Interaction Between the ParF ATPase and the ParG Centromere Binding Protein

Frontiers in Molecular Biosciences, 2020
The molecular events that underpin genome segregation during bacterial cytokinesis have not been fully described. The tripartite segrosome complex that is encoded by the multiresistance plasmid TP228 in Escherichia coli is a tractable model to decipher ...
Marisa Caccamo, Aneta Dobruk-Serkowska, Fernando Rodríguez-Castañeda, Cecilia Pennica, Daniela Barillà, Finbarr Hayes   +5 more
doaj   +1 more source

Replication catastrophe is responsible for intrinsic PAR glycohydrolase inhibitor-sensitivity in patient-derived ovarian cancer models

Journal of Experimental & Clinical Cancer Research, 2021
Background Patients with ovarian cancer often present at advanced stage and, following initial treatment success, develop recurrent drug-resistant disease. PARP inhibitors (PARPi) are yielding unprecedented survival benefits for women with BRCA-deficient
Camilla Coulson-Gilmer, Robert D. Morgan, Louisa Nelson, Bethany M. Barnes, Anthony Tighe, René Wardenaar, Diana C. J. Spierings, Helene Schlecht, George J. Burghel, Floris Foijer, Sudha Desai, Joanne C. McGrail, Stephen S. Taylor   +12 more
doaj   +1 more source