Results 41 to 50 of about 6,989 (168)
Quantifying the Severity of Phytophthora Root Rot Disease in Avocado Trees Using Image Analysis
Remote Sensing, 2018 Phytophthora root rot (PRR) infects the roots of avocado trees, resulting in reduced uptake of water and nutrients, canopy decline, defoliation, and, eventually, tree mortality.
Arachchige Surantha Ashan Salgadoe +4 more
doaj +1 more source
International Journal of Cosmetic Science, EarlyView.GA text A 30% Picea abies resin extract cream combined antimicrobial, anti‐inflammatory and early pro‐repair activities relevant to acne‐prone skin. The formulation showed strong activity against Cutibacterium acnes, reduced inflammatory cytokines and demonstrated promising tolerability and efficacy in an exploratory in‐use study. Abstract Objective To
Simone Parrotta +4 more
wiley +1 more source
Targeting the DNA Damage Response in Cancer
MedComm, Volume 7, Issue 10, October 2026.Targeting the DNA damage response (DDR) reshapes both tumor vulnerability and antitumor immunity. DNA lesions and DDR inhibitors can promote cytosolic nucleic‐acid sensing, antigen presentation, and immune activation, but can also induce adaptive immune escape.
Yihuan Qiao +4 more
wiley +1 more source
Selective small molecule PARG inhibitor causes replication fork stalling and cancer cell death
Nature Communications, 2019 PARG catalyzes the removal of poly(ADP-ribose) (PAR) from target proteins and executes critical functions in the DNA damage response. Here the authors provide structural and biological insight with small molecule PARG inhibitors and show that PARG ...
Jerry H. Houl +20 more
doaj +1 more source
PARG Inhibition Modulates Viability, Clonogenicity and Migration of Breast Cancer Cells Response to Radiotherapy [PDF]
Zagazig University Medical JournalBackground Targeting DNA repair through inhibition of poly (ADP-ribose) glycohydrolase (PARG) enzyme is a promising strategy to modulate cancer resistance to traditional therapy.
Nadia Abd El Moneim +6 more
doaj +1 more source
Nature Communications, 2020 Poly(ADP-ribose) glycohydrolase (PARG) is involved in different cellular processes including DNA repair. Here the authors reveal a role for PARG in regulating meiotic DNA double strand break induction and repair in Caenorhabditis elegans.
Eva Janisiw +8 more
doaj +1 more source
Spatial Cell Death and Oxidative Stress Dynamics in Gas Plasma‐Treated Tumor Tissues
Advanced NanoBiomed Research, Volume 6, Issue 9, September 2026.Schematic representation of the four experimental models to study tissue penetration and oxidation. Four tissue models were used. Human pancreatic cancer cells were grown on the chorioallantois membrane of chicken embryos and gas plasma‐treated in ovo, murine colorectal tumor tissue was gas plasma‐exposed ex vivo, murine squamous cell carcinoma cells ...
Anke Schmidt +4 more
wiley +1 more source
Purification of Recombinant Human PARG and Activity Assays [PDF]
, 2017 The purification of Poly(ADP-ribose) glycohydrolase (PARG) from overexpressing bacteria Escherichia coli is described here to a fast and reproducible one chromatographic step protocol. After cell lysis, GST-PARG-fusion proteins from the crude extract are affinity purified by a Glutathione 4B Sepharose chromatographic step.
Amé, Jean-Christophe +4 more
openaire +2 more sources
Clinical and Translational Medicine, Volume 16, Issue 9, September 2026.Under conditions of low TRIM25 expression, the ubiquitination fate of ENO1 shifts to K48‐linked ubiquitination and degradation. TRIM25 enhances the deubiquitination of ENO1 by recruiting USP7, effectively inhibiting its proteasomal degradation and significantly increasing ENO1 stabilization.
Xiaoming Liu +10 more
wiley +1 more source